Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
impact, RWD domain protein
Synonyms:
E430016J11Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Impact mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Impact by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypoglycemia, Hypothermia OMIM:610006
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Failure to thrive, Hypoglycemia, Hypothermia OMIM:245400
Primary Erythromelalgia
Hypothermia ORPHA:90026
Idiopathic Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:95717
Orthostatic Hypotension 1
Intermittent hypothermia, Neonatal hypoglycemia OMIM:223360
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia, Umbilical hernia, Large for gestational age ORPHA:226313
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Failure to thrive, Hypoglycemia, Hypothermia OMIM:251880
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Menkes Disease
Hypothermia OMIM:309400
Permanent Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:226292
Carnitine-Acylcarnitine Translocase Deficiency
Cyanosis, Fasting hypoglycemia, Hypoketotic hypoglycemia, Hypothermia ORPHA:159
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Hip contracture, Hypothermia, Abnormality of temperature regulation, Fever, Obesity, Elbow flexio... OMIM:618493
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypoketotic hypoglycemia, Hypothermia, Small for gestational age, Overweight, Obesity ORPHA:26793
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Combined Oxidative Phosphorylation Deficiency 37
Failure to thrive, Hypoglycemia, Hypothermia OMIM:618329
Familial Thyroid Dyshormonogenesis
Umbilical hernia, Hypothermia ORPHA:95716
Dopamine Beta-Hydroxylase Deficiency
Hypoglycemia, Hyperinsulinemia, Hypothermia, Insulin resistance ORPHA:230
3-Hydroxy-3-Methylglutaric Aciduria
Hypothermia, Weight loss, Fever, Recurrent hypoglycemia, Nonketotic hypoglycemia ORPHA:20
Meningococcal Meningitis
Hypothermia, Fever ORPHA:33475
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia, Small for gestational age OMIM:618775
Alexander Disease
Failure to thrive, Dysphagia, Diabetes mellitus, Hypothermia ORPHA:58
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:442
Congenital Enterovirus Infection
Hypothermia, Fever ORPHA:292
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hypothermia, Polyphagia, Hyperglycemia, Polydipsia, Fever, Cyanosis, Obesity ORPHA:293987
Mitochondrial Dna-Associated Leigh Syndrome
Failure to thrive, Hypothermia, Dysphagia, Fever ORPHA:255210
Menkes Disease
Chondrocalcinosis, Hypoglycemia, Hypothermia, Hernia, Inguinal hernia, Atypical scarring of skin,... ORPHA:565
Isolated Thyroid-Stimulating Hormone Deficiency
Failure to thrive, Umbilical hernia, Hypothermia ORPHA:90674
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Failure to thrive, Hypothermia, Hypoglycemia, Flexion contracture ORPHA:17
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Failure to thrive, Hypoglycemia, Hypothermia ORPHA:79282
Genetic Transient Congenital Hypothyroidism
Umbilical hernia, Hypothermia ORPHA:226316
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Hypothermia, Dysphagia, Flexion contracture ORPHA:99027
Hypothyroidism Due To Tsh Receptor Mutations
Umbilical hernia, Hypothermia ORPHA:90673
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypoglycemia, Umbilical hernia, Hypothermia, Overweight ORPHA:226307
Neuroleptic Malignant Syndrome
Hypothermia, Dysphagia, Fever ORPHA:94093
Ethylene Glycol Poisoning
Cyanosis, Hypothermia ORPHA:31826
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Occipital Horn Syndrome
Keloids, Dysphagia, Scarring, Hypothermia, Atypical scarring of skin, Hiatus hernia, Inguinal her... ORPHA:198
Hereditary Sensory And Autonomic Neuropathy Type 4
Recurrent fever, Dysphagia, Unexplained fevers, Hypothermia, Corneal scarring, Fasciitis, Atypica... ORPHA:642
Aromatic L-Amino Acid Decarboxylase Deficiency
Temperature instability, Intermittent hypothermia OMIM:608643
Marburg Hemorrhagic Fever
Hypothermia, Hypoglycemia, Fever ORPHA:99826
Hypothyroidism, Congenital, Nongoitrous, 2
Umbilical hernia, Hypothermia OMIM:218700
Sarcoidosis
Hypothermia, Weight loss, Scarring, Fever ORPHA:797
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Uterine prolapse, Dysphagia, Hypothermia ORPHA:438213

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Impact

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Impact.

No publications found that use IMPC mice or data for Impact.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Impacttm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Impacttm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Impacttm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Impacttm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Impactem1(IMPC)Ccpcz Exon Deletion Mice

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