Gene: Bhlhe40

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Name
basic helix-loop-helix family, member e40
MGI ID
MGI:1097714
Synonyms
Stra14 Stra13 Clast5 eip1 (E47 interaction protein 1) DEC1 C130042M06Rik Sharp2 CR8 cytokine response gene 8 Bhlhb2
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased fasting circulating glucose level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 8.79×10-08
increased lean body mass Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 3.51×10-06
increased mean corpuscular hemoglobin Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 2.70×10-12
decreased T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.40×10-06
decreased total body fat amount Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.41×10-05
decreased CD8-positive, alpha-beta T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.40×10-06
increased bone mineral content Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 5.87×10-09
decreased circulating HDL cholesterol level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 9.30×10-07
decreased alpha-beta T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.50×10-06
increased mean corpuscular volume Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 2.86×10-06
increased B cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.60×10-06
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased effector memory CD8-positive, alpha-beta T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased Ly6C low monocyte number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 3.20×10-05
decreased circulating glycerol level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 6.60×10-07
increased bone mineral density Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 8.47×10-05
decreased fasting circulating glucose level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 8.79×10-08
decreased CD4-positive, alpha beta T cell number Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.00×10-07
decreased circulating calcium level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 1.85×10-05
decreased circulating cholesterol level Bhlhe40tm1b(KOMP)Wtsi HOM Early adult 5.21×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No  (2/2)  Section images
Bone marrow 2 No  (2/2)  Section images
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2)  Section images
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No  (2/2)  Section images
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No  (2/2)  Section images
Hypothalamus 2 No  (2/2)  Section images
Kidney 2 No  (18/584)  (2/2)  Section images
Large intestine 2 No  (10/584)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No  (2/2)  Section images
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/2)  Section images
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No  (2/2)  Section images
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (2/2)  Section images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2)  Section images
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584)  (2/2)  Section images
Stomach 2 No  (12/584)  (2/2)  Section images
Striatum 2 No  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (2/584)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (2/2)  Section images
Thyroid gland 2 No  (15/584)  (2/2)  Section images
Trachea 2 No  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (1/3) N/A
Dorsal root ganglion 2  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/3)  Wholemount images
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 2  (1/58) N/A
Hand 2  (1/503) N/A
Head 2  (5/504)  (1/3) N/A
Heart 2  (1/504)  (2/3) N/A
Hindbrain 2  (6/504)  (1/3) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) Image Only N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 2  (1/70)  (1/3) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69)  (1/3) N/A
Tail 2  (1/504)  (2/3) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Original Image
Adult LacZ: LacZ Images Section
47 Images
Sleep Wake: Wake state (bmp file)
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
Eye Morphology: Images Ophthalmoscopy
12 Images
Embryo LacZ: LacZ images wholemount
8 Images
DSS Histology
8 Images
Legacy Phenotype Associated Images

View all 55 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Bhlhe40tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bhlhe40tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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