Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
Opn1lw,  G/R opsin,  MWS opsin,  R/G opsin,  M opsin,  Green opsin,  green long wavelength sensitive cone opsin,  green LWS cone opsin,  ML-opsin,  Gcp,  Rsvp,  Midwavelength sensitive opsin

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Opn1mw mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Opn1mw by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Colorblindness, Partial, Protan Series
Protanomaly OMIM:303900
Colorblindness, Partial, Deutan Series
Deuteranomaly OMIM:303800
Cone Rod Dystrophy
Color vision defect, Photophobia, Nyctalopia, Visual impairment ORPHA:1872
Blue Cone Monochromacy
Reduced visual acuity, Blue cone monochromacy, Visual impairment, Myopia, Photophobia OMIM:303700
Blue Cone Monochromatism
Blue cone monochromacy, Photophobia, Visual impairment ORPHA:16

The table below shows human diseases predicted to be associated to Opn1mw by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Prolonged Electroretinal Response Suppression 1
Bradyopsia OMIM:608415
Colorblindness, Partial, Deutan Series
Deuteranomaly OMIM:303800
Colorblindness, Partial, Protan Series
Protanomaly OMIM:303900
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
Tritanomaly, Color vision defect, Dyschromatopsia OMIM:190900
Stargardt Disease 1
Retinitis pigmentosa inversa, Macular degeneration, Bull's eye maculopathy OMIM:248200
Retinal Dystrophy, Reticular Pigmentary, Of Posterior Pole
Reticular pigmentary degeneration, Retinal dystrophy, Drusen OMIM:267800
Myopia 18, Autosomal Recessive
Myopia OMIM:255500
Myopia 9
Myopia OMIM:609258
Myopia 10
Myopia OMIM:609259
Myopia 7
Myopia OMIM:609256
Myopia 8
Myopia OMIM:609257
Myopia 15, Autosomal Dominant
Myopia OMIM:612717
Myopia 1, X-Linked
Myopia OMIM:310460
Macular Degeneration, Age-Related, 13
Macular scar, Macular degeneration, Choroidal neovascularization, Drusen OMIM:615439
Photophobia, Visual impairment ORPHA:75374
Retinitis Pigmentosa 36
Rod-cone dystrophy, Macular degeneration, Bone spicule pigmentation of the retina, Attenuation of... OMIM:610599
Exudative Vitreoretinopathy 7
Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal degeneration, Retinal detachment OMIM:617572
Macular Degeneration, Age-Related, 6
Macular degeneration OMIM:613757
Macular Degeneration, Age-Related, 4
Macular degeneration OMIM:610698
Macular Degeneration, Age-Related, 15
Macular degeneration OMIM:615591
Macular Degeneration, Age-Related, 2
Macular degeneration OMIM:153800
Macular Degeneration, Age-Related, 11
Macular degeneration OMIM:611953
Newfoundland Rod-Cone Dystrophy
Color vision defect, Scotoma, Nyctalopia, Visual impairment OMIM:607476
Exudative Vitreoretinopathy 3
Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal exudate, Retinal detachment OMIM:605750
Corneal Dystrophy, Gelatinous Drop-Like
Blurred vision, Reduced visual acuity, Photophobia, Visual impairment OMIM:204870
Silent Sinus Syndrome
Abnormality of vision ORPHA:71276
Retinoschisis 1, X-Linked, Juvenile
Retinal pigment epithelial atrophy, Vitreous hemorrhage, Retinal atrophy, Retinal degeneration, M... OMIM:312700
Hyperopia, High
High hypermetropia OMIM:238950
Retinal Degeneration And Epilepsy
Retinal degeneration OMIM:267740
Progressive visual loss, Visual impairment, Myopia, Nyctalopia, Abnormality of vision ORPHA:180
Late-Onset Retinal Degeneration
Retinopathy, Sub-RPE deposits, Retinal degeneration, Choroidal neovascularization, Chorioretinal ... OMIM:605670
X-Linked Retinal Dysplasia
Retinal dysplasia, Abnormality of retinal pigmentation, Abnormal retinal vascular morphology ORPHA:1852
Sorsby Pseudoinflammatory Fundus Dystrophy
Retinal pigment epithelial atrophy, Pigmentary retinopathy, Hyporeflective spaces on macular OCT,... ORPHA:59181
Retinopathy, Pericentral Pigmentary, Dominant
Retinopathy, Retinal atrophy, Retinal dystrophy, Bone spicule pigmentation of the retina, Attenua... OMIM:180210
Myopia 22, Autosomal Dominant
Reduced visual acuity, High myopia OMIM:615420
Familial Pterygium Of The Conjunctiva
Abnormality of vision ORPHA:2989
Familial Drusen
Macular drusen, Hypoautofluorescent macular lesion, Hyperautofluorescent macular lesion, Macular ... ORPHA:75376
Cone Rod Dystrophy
Color vision defect, Photophobia, Nyctalopia, Visual impairment ORPHA:1872
Macular Degeneration, Age-Related, 1
Macular drusen, Macular hemorrhage, Macular degeneration, Choroidal neovascularization, Foveal hy... OMIM:603075
Blue Cone Monochromacy
Reduced visual acuity, Blue cone monochromacy, Visual impairment, Myopia, Photophobia OMIM:303700
Birdshot Chorioretinopathy
Retinal thinning, Abnormal choroid morphology, Vitritis, Vitreous floaters, Choroidal neovascular... ORPHA:179
Retinitis Pigmentosa 92
Constriction of peripheral visual field, Nyctalopia, Visual impairment, Paracentral scotoma OMIM:619614
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Retinitis Pigmentosa 70
Rod-cone dystrophy, Retinal degeneration, Macular degeneration, Attenuation of retinal blood vess... OMIM:615922
Retinitis Pigmentosa 50
Rod-cone dystrophy, Attenuation of retinal blood vessels, Retinal flecks, Retinal detachment, Opt... OMIM:613194
Retinitis Pigmentosa 32
Retinal degeneration, Bone spicule pigmentation of the retina, Attenuation of retinal blood vesse... OMIM:609913
Myopia 23, Autosomal Recessive
Reduced visual acuity, High myopia, Visual impairment OMIM:615431
Retinitis Pigmentosa 13
Rod-cone dystrophy, Optic disc drusen, Asteroid hyalosis, Retinal degeneration, Bone spicule pigm... OMIM:600059
Senior-Loken Syndrome 7
Retinal degeneration OMIM:613615
Myopia 26, X-Linked, Female-Limited
High myopia OMIM:301010
Myopia 6
High myopia OMIM:608908
Myopia 21, Autosomal Dominant
High myopia OMIM:614167
Myopia 24, Autosomal Dominant
High myopia OMIM:615946
Myopia 19, Autosomal Dominant
High myopia OMIM:613969
Coloboma Of Optic Nerve
Retinal detachment, Optic disc coloboma OMIM:120430
Vitreoretinal Degeneration, Snowflake Type
Retinal detachment, Retinal dots, Optically empty vitreous, Snowflake vitreoretinal degeneration OMIM:193230
Exudative Vitreoretinopathy 2, X-Linked
Exudative vitreoretinopathy, Intraretinal exudate, Retinal fold, Retinal hole, Falciform retinal ... OMIM:305390
Night Blindness, Congenital Stationary, Type 1A
Hemeralopia, High myopia, Congenital stationary night blindness OMIM:310500
Blue Cone Monochromatism
Blue cone monochromacy, Photophobia, Visual impairment ORPHA:16
Exudative Vitreoretinopathy 1
Exudative vitreoretinopathy, Vitreous hemorrhage, Falciform retinal fold, Posterior vitreous deta... OMIM:133780
Myopia 25, Autosomal Dominant
Retinal detachment OMIM:617238
Myopia 2, Autosomal Dominant
Retinal detachment OMIM:160700
Myopia 3, Autosomal Dominant
Retinal detachment OMIM:603221
Myopia 5, Autosomal Dominant
Retinal detachment OMIM:608474
Vitreoretinopathy, Neovascular Inflammatory
Large hyperpigmented retinal spots, Posterior retinal neovascularization, Vitreous hemorrhage, Pe... OMIM:193235


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Opn1mw

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Opn1mw.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy. Investigative ophthalmology & visual science (August 2019) Opn1mwtm1a(EUCOMM)Wtsi PMC6716949
Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy. Molecular vision (January 2018) Opn1mwtm1a(EUCOMM)Wtsi PMC5757852
Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy. Scientific reports (July 2017) Opn1mwtm1a(EUCOMM)Wtsi PMC5532293

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MGI Allele Allele Type Produced
Opn1mwtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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