Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cytochrome P450, family 4, subfamily a, polypeptide 14
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cyp4a14 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cyp4a14 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Coronary Artery Disease, Autosomal Dominant, 1
Myocardial infarction, Hypertension, Hypercholesterolemia OMIM:608320
Hyperaldosteronism, Familial, Type Iv
Hypertension OMIM:617027
Glomerulopathy With Fibronectin Deposits 1
Hypertension, Nephrotic syndrome, Stage 5 chronic kidney disease, Microscopic hematuria, Proteinu... OMIM:137950
Focal Segmental Glomerulosclerosis 2
Hypertension, Focal segmental glomerulosclerosis, Nephrotic syndrome, Stage 5 chronic kidney dise... OMIM:603965
Iga Nephropathy, Susceptibility To, 3
Hypertension, IgA deposition in the glomerulus, Hematuria, Stage 5 chronic kidney disease, Mesang... OMIM:616818
Nail-Patella-Like Renal Disease
Hypertension, Microscopic hematuria, Glomerulopathy, Proteinuria, Renal insufficiency ORPHA:2613
Iga Nephropathy, Susceptibility To, 2
Hypertension, IgA deposition in the glomerulus, Hematuria, Nephritis, Stage 5 chronic kidney dise... OMIM:613944
Congenital Pulmonary Veins Atresia Or Stenosis
Hypertension ORPHA:3188
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Glomerulopathy With Fibronectin Deposits 2
Hypertension, Nephrotic syndrome, Renal cell carcinoma, Stage 5 chronic kidney disease, Microscop... OMIM:601894
Metachromatic Leukodystrophy, Adult-Onset, With Normal Arylsulfatase A
Urinary incontinence, Urinary urgency, Hypotension OMIM:156310
Renal Failure, Progressive, With Hypertension
Hypertension, Nephritis, Stage 5 chronic kidney disease, Microscopic hematuria, Proteinuria, Rena... OMIM:161900
Focal Segmental Glomerulosclerosis 5
Hypertension, Focal segmental glomerulosclerosis, Stage 5 chronic kidney disease, Microscopic hem... OMIM:613237
Focal Segmental Glomerulosclerosis 3, Susceptibility To
Hypertension, Focal segmental glomerulosclerosis, Hematuria, Proteinuria, Renal insufficiency OMIM:607832
Hydroxykynureninuria
Aminoaciduria, Renal tubular dysfunction, Tachycardia, Hypotension OMIM:236800
Primary Membranoproliferative Glomerulonephritis
Hypertension, Nephrotic syndrome, Stage 5 chronic kidney disease, Myocardial infarction, Renal in... ORPHA:54370
Spastic Paraplegia-Nephritis-Deafness Syndrome
Hypertension, Proteinuria, Nephropathy ORPHA:2820
Iga Nephropathy, Susceptibility To, 1
Hypertension, IgA deposition in the glomerulus, Hematuria, Nephritis, Stage 5 chronic kidney dise... OMIM:161950
Coronary Artery Disease, Autosomal Dominant 2
Hypertension, Hyperlipidemia, Myocardial infarction, Hypercholesterolemia, Hypertriglyceridemia, ... OMIM:610947
Focal Segmental Glomerulosclerosis 1
Hypertension, Focal segmental glomerulosclerosis, Hyperlipidemia, Stage 5 chronic kidney disease,... OMIM:603278
Fibronectin Glomerulopathy
Cerebral hemorrhage, Hypertension, Abnormal glomerular mesangium morphology, Nephrotic syndrome, ... ORPHA:84090
Denys-Drash Syndrome
Hypertension, Nephrotic syndrome, Nephropathy, Proteinuria, Nephroblastoma ORPHA:220
Osteochondrodysplasia, Rhizomelic, With Callosal Agenesis, Thrombocytopenia, Hydrocephalus, And Hypertension
Hypertension OMIM:166990
Paragangliomas 6
Hypertension OMIM:618464
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Long Qt Syndrome 13
Syncope, Hypertension, Prolonged QT interval, Atrial fibrillation, Atrioventricular block, Tachyc... OMIM:613485
Liddle Syndrome
Hypertension, Cerebral ischemia, Nephropathy, Renal insufficiency, Arrhythmia ORPHA:526
Trimethylaminuria
Trimethylaminuria, Hypertension, Tachycardia OMIM:602079
Melorheostosis With Osteopoikilosis
Hypertension ORPHA:1879
Arterial Calcification, Generalized, Of Infancy, 2
Myocardial infarction, Hypertension, Congestive heart failure, Nephrocalcinosis OMIM:614473
Cystic Hamartoma Of Lung And Kidney
Hypertension, Multicystic kidney dysplasia ORPHA:2111
Hyperaldosteronism, Familial, Type Ii
Hypertension OMIM:605635
Congenital Tricuspid Stenosis
Tricuspid stenosis, Pulmonary arterial hypertension, Tricuspid regurgitation, Congestive heart fa... ORPHA:95459
Lessel-Kubisch Syndrome
Hypertension, Renal insufficiency, Renal hypoplasia OMIM:618681
Amyloidosis, Familial Visceral
Hypertension, Nephrotic syndrome, Hematuria, Nephropathy, Proteinuria OMIM:105200
Brachydactyly-Arterial Hypertension Syndrome
Hypertension ORPHA:1276
Idiopathic Non-Lupus Full-House Nephropathy
Hypertension, Abnormal glomerular mesangium morphology, Nephrotic syndrome, Acute kidney injury, ... ORPHA:567544
Adenine Phosphoribosyltransferase Deficiency
Macroscopic hematuria, Hypertension, Atrial fibrillation, Urinary retention, Urinary hesitancy, D... ORPHA:976
Polycystic Kidney Disease 6 With Or Without Polycystic Liver Disease
Hypertension, Decreased glomerular filtration rate, Renal insufficiency, Stage 5 chronic kidney d... OMIM:618061
Hypertension And Brachydactyly Syndrome
Hypertension OMIM:112410
Lipodystrophy, Familial Partial, Type 4
Hypertension, Hypertriglyceridemia OMIM:613877
Obesity Due To Sim1 Deficiency
Postural hypotension with compensatory tachycardia, Hypotension ORPHA:369873
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Renal tubular atrophy, Hypertension, Renal hypoplasia, Tubulointerstitial nephritis, Renal cortic... OMIM:174000
Aa Amyloidosis
Nephrotic syndrome, Abnormality of the kidney, Acute kidney injury, Nephropathy, Chronic kidney d... ORPHA:85445
Cryoglobulinemia, Familial Mixed
Hypertension, Abnormal renal physiology, Hematuria, Chronic kidney disease, Proteinuria OMIM:123550
Renal Tubular Dysgenesis
Abnormality of the urinary system, Renotubular dysgenesis, Hypotension, Anuria OMIM:267430
Late-Onset Familial Hypoaldosteronism
Renal sodium wasting, Orthostatic hypotension, Elevated serum 11-deoxycortisol, Abnormal circulat... ORPHA:556037
Analbuminemia
Hypercholesterolemia, Hypotension OMIM:616000
Cardiomyopathy-Cataract-Hip Spine Disease Syndrome
Hypertrophic cardiomyopathy, Hypertension, Congestive heart failure, Pulmonary embolism, Arrhythmia ORPHA:1345
Liddle Syndrome 3
Hypertension OMIM:618126
Hyperaldosteronism, Familial, Type I
Abnormality of the urinary system, Hypertension, Hyperaldosteronism OMIM:103900
Obesity Due To Melanocortin 4 Receptor Deficiency
Hypertension, Hypertriglyceridemia ORPHA:71529
Early-Onset Familial Hypoaldosteronism
Renal sodium wasting, Orthostatic hypotension, Elevated serum 11-deoxycortisol, Abnormal circulat... ORPHA:556030
Renal Hypoplasia
Hypertension, Hydronephrosis, Abnormality of the ureter, Urethral valve, Pelvic kidney, Glomerulo... ORPHA:93101
Alport Syndrome 2, Autosomal Recessive
Glomerular basement membrane lamellation, Hypertension, Nephrotic syndrome, Hematuria, Nephritis,... OMIM:203780
Atrial Fibrillation, Familial, 14
Prolonged PR interval, Hypertension, Paroxysmal atrial fibrillation, ST segment elevation OMIM:615378
Cardiogenic Shock
Right ventricular failure, Mitral regurgitation, Low pulse pressure, Elevated jugular venous pres... ORPHA:97292
Rowley-Rosenberg Syndrome
Hypertension, Aminoaciduria, Pulmonary arterial hypertension OMIM:268500
Phosphoribosylpyrophosphate Synthetase Superactivity
Renal insufficiency, Hypertension, Arrhythmia, Cardiomyopathy ORPHA:3222
Perry Syndrome
Hypotension ORPHA:178509
Nephronophthisis 1
Renal tubular atrophy, Hypertension, Nephronophthisis, Tubulointerstitial fibrosis, Renal cortico... OMIM:256100
Moyamoya Disease 6 With Or Without Achalasia
Ischemic stroke, Hypertension, Raynaud phenomenon OMIM:615750
Moyamoya Disease With Early-Onset Achalasia
Hypertension, Raynaud phenomenon ORPHA:401945
Ochoa Syndrome
Hypertension, Hydronephrosis, Recurrent urinary tract infections, Urinary incontinence, Vesicoure... ORPHA:2704
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Hypertension OMIM:605115
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease
Hypertension, Polycystic kidney dysplasia, Renal insufficiency, Mitral regurgitation OMIM:173900
Malignant Hyperthermia, Susceptibility To, 1
Myoglobinuria, Tachycardia, Hypotension OMIM:145600
Tako-Tsubo Cardiomyopathy
Syncope, Hypertension, Prolonged QT interval, Decreased QRS voltage, Ventricular arrhythmia, Mitr... ORPHA:66529
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Renal salt wasting, Hypotension, Hyperaldosteronism OMIM:264350
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Hypertension, Anuria, Hematuria, Hemolytic-uremic syndrome, Acute kidney injury, Proteinuria OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Hypertension, Anuria, Hematuria, Hemolytic-uremic syndrome, Acute kidney injury, Proteinuria OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Hypertension, Anuria, Hematuria, Hemolytic-uremic syndrome, Acute kidney injury, Proteinuria OMIM:612925
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Hypertension, Anuria, Hematuria, Hemolytic-uremic syndrome, Acute kidney injury, Proteinuria OMIM:612924
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Hypertension, Anuria, Hematuria, Hemolytic-uremic syndrome, Acute kidney injury, Proteinuria OMIM:612926
Bartter Syndrome, Type 3
Renal salt wasting, Increased urinary potassium, Hypocalciuria, Renal potassium wasting, Hyperald... OMIM:607364
Chromosome 5Q12 Deletion Syndrome
Hypotension OMIM:615668
Aapoaiv Amyloidosis
Abnormal cardiac ventricular function, Hypertension, Hypertrophic cardiomyopathy, Sinus bradycard... ORPHA:439232
Nipah Virus Disease
Hypotension ORPHA:99825
Congenital Isolated Acth Deficiency
Hypotension, Decreased circulating cortisol level ORPHA:199296
Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease
Hypertension, Polycystic kidney dysplasia OMIM:600666
Corticosterone Methyloxidase Type I Deficiency
Renal salt wasting, Hypotension OMIM:203400
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Hypertension, Stage 5 chronic kidney disease, Recurrent urinary tract infections, Polycystic kidn... OMIM:613095
Systemic Capillary Leak Syndrome
Myocarditis, Pericarditis, Oliguria, Abnormal renal tubule morphology, Renal insufficiency, Arrhy... ORPHA:188
Snakebite Envenomation
Intracranial hemorrhage, Epistaxis, Tachycardia, Cerebral ischemia, Cardiogenic shock, Myocardial... ORPHA:449285
Hydroxykynureninuria
Renal tubular acidosis, Tachycardia, Hypotension ORPHA:79155
Posterior Urethral Valve
Hypertension, Hydronephrosis, Urinary retention, Urethral stenosis, Congenital posterior urethral... ORPHA:93110
Pseudohypoaldosteronism, Type Iia
Hypertension OMIM:145260
Abdominal Obesity-Metabolic Syndrome 3
Myocardial infarction, Hypertension, Hypercholesterolemia OMIM:615812
Arterial Calcification, Generalized, Of Infancy, 1
Myocardial infarction, Hypertension, Congestive heart failure OMIM:208000
Erythrocytosis, Familial, 2
Cerebral hemorrhage, Hypotension OMIM:263400
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension, Hyperaldosteronism OMIM:177735
Infant Acute Respiratory Distress Syndrome
Cardiac arrest, Tachycardia, Bradycardia, Hypotension ORPHA:70587
Glutaric Aciduria Iii
Hypertension, Glutaric aciduria OMIM:231690
Nephronophthisis 2
Pulmonary insufficiency, Hypertension, Chronic tubulointerstitial nephritis, Nephronophthisis, St... OMIM:602088
Alport Syndrome 3, Autosomal Dominant
Glomerular basement membrane lamellation, Hypertension, Nephrotic syndrome, Nephrocalcinosis, Hem... OMIM:104200
Alagille Syndrome 2
Hypertension, Renal hypoplasia, Renal tubular acidosis, Hematuria, Renal cyst, Pulmonic stenosis,... OMIM:610205
Fanconi Renotubular Syndrome 5
Hypertension, Tubulointerstitial fibrosis, Stage 5 chronic kidney disease, Glycosuria, Aminoacidu... OMIM:618913
Inhalational Anthrax
Internal hemorrhage, Hypotension ORPHA:247257
Frasier Syndrome
Hypertension, Focal segmental glomerulosclerosis, Nephrotic syndrome, Renal insufficiency, Glomer... ORPHA:347
Familial Hypoaldosteronism
Renal salt wasting, Orthostatic hypotension, Decreased urinary potassium, Proximal renal tubular ... ORPHA:427
Renal Dysplasia
Abnormal renal calyx morphology, Chronic kidney disease, Hypertension, Abnormal nephron morpholog... ORPHA:93108
Mercury Poisoning
Hypertension, Acute kidney injury, Tachycardia, Hypotension ORPHA:330021
Pulmonary Hypertension, Primary, 1
Right ventricular failure, Telangiectasia, Hypertension, Pulmonary arterial hypertension, Elevate... OMIM:178600
Car T Cell Therapy-Associated Cytokine Release Syndrome
Decreased urine output, Reduced ejection fraction, Tachycardia, Heart block, Acute kidney injury,... ORPHA:542323
Carnitine-Acylcarnitine Translocase Deficiency
Premature ventricular contraction, Ventricular tachycardia, Atrioventricular block, Cardiomyopath... OMIM:212138
Hyperaldosteronism, Familial, Type Iii
Hypertension, Hypercalciuria, Polyuria, Hyperaldosteronism OMIM:613677
Liddle Syndrome 1
Hypertension, Renal insufficiency OMIM:177200
Acquired Von Willebrand Syndrome
Intracranial hemorrhage, Mitral regurgitation, Aortic regurgitation, Epistaxis, Joint hemorrhage,... ORPHA:99147
Adult Acute Respiratory Distress Syndrome
Shock, Vasculitis, Hypotension ORPHA:70578
Neurodevelopmental Disorder With Seizures And Speech And Walking Impairment
Hypotension OMIM:618480
Glycogen Storage Disease Of Heart, Lethal Congenital
Bradycardia, Cardiomyopathy, Congestive heart failure, Shortened PR interval, Hypotension OMIM:261740
Relapsing Fever
Abnormality of the urinary system, Hematuria, Epistaxis, Tachycardia, Acute kidney injury, Hypote... ORPHA:91547
Neuroendocrine Tumor Of The Colon
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100080
Dengue Fever
Cerebral hemorrhage, Gastrointestinal hemorrhage, Epistaxis, Hypotension ORPHA:99828
Scrub Typhus
Myocarditis, Renal insufficiency, Hypotension ORPHA:83317
Familial Hyperaldosteronism Type Ii
Hypertension, Epistaxis, Intracranial hemorrhage, Glucocortocoid-insensitive primary hyperaldoste... ORPHA:404
Liddle Syndrome 2
Hypertension OMIM:618114
Cutaneous Mastocytoma
Telangiectasia macularis eruptiva perstans, Telangiectasia of the skin, Hypotension ORPHA:79455
Nephronophthisis-Like Nephropathy 1
Renal tubular atrophy, Hypertension, Nephronophthisis, Renal corticomedullary cysts, Stage 5 chro... OMIM:613159
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Hypertension, Intracranial hemorrhage, Abnormal T-wave, Increased urinary potassium, Palpitations... ORPHA:231625
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Alport Syndrome 1, X-Linked
Glomerular basement membrane lamellation, Hypertension, Nephrotic syndrome, Nephritis, Stage 5 ch... OMIM:301050
Abdominal Obesity-Metabolic Syndrome 4
Myocardial infarction, Hypertension, Hypertriglyceridemia OMIM:618620
Bronchial Neuroendocrine Tumor
Right ventricular failure, Facial telangiectasia, Palpitations, Increased circulating cortisol le... ORPHA:97287
Autosomal Dominant Polycystic Kidney Disease
Hypertension, Decreased glomerular filtration rate, Hematuria, Renal cyst, Pyelonephritis, Nephro... ORPHA:730
Neuroendocrine Tumor Of The Rectum
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100082
Pseudohypoaldosteronism, Type Iib
Hypertension OMIM:614491
Pseudohypoaldosteronism, Type Iid
Hypertension OMIM:614495
Apparent Mineralocorticoid Excess
Hypertension, Nephrocalcinosis, Abnormality of circulating cortisol level, Abnormal urine sodium ... ORPHA:320
Denys-Drash Syndrome
Hypertension, Focal segmental glomerulosclerosis, Nephrotic syndrome, Stage 5 chronic kidney dise... OMIM:194080
Meningococcal Meningitis
Shock, Renal insufficiency, Hypotension ORPHA:33475
Ethylene Glycol Poisoning
Shock, Hypertension, Renal tubular dysfunction, Prolonged QT interval, Atrial fibrillation, Decre... ORPHA:31826
Multiple Endocrine Neoplasia, Type Iia
Hypertension, Elevated urinary epinephrine, Elevated urinary vanillylmandelic acid, Palpitations,... OMIM:171400
Hemorrhagic Fever-Renal Syndrome
Tubulointerstitial nephritis, Decreased glomerular filtration rate, Melena, Chronic kidney diseas... ORPHA:340
Carnitine-Acylcarnitine Translocase Deficiency
Ventricular tachycardia, Cardiomyopathy, Dicarboxylic aciduria, Oliguria, Arrhythmia, Hypotension ORPHA:159
Infant Botulism
Hypertension, Cardiac arrest, Hypotension ORPHA:178478
Colchicine Poisoning
Myocarditis, Cardiogenic shock, Renal insufficiency, Oliguria, Congestive heart failure, Hypovole... ORPHA:31824
Legionnaires Disease
Myocarditis, Pericarditis, Hematuria, Proteinuria, Renal insufficiency, Arrhythmia, Hypotension ORPHA:549
Atrioventricular Septal Defect 3
Hypertension, Pulmonary arterial hypertension, Congestive heart failure, First degree atrioventri... OMIM:600309
Post-Traumatic Pituitary Deficiency
Hypotension ORPHA:95619
Serotonin Syndrome
Hypertension, Acute kidney injury, Tachycardia, Hypotension ORPHA:43116
Ectopic Aldosterone-Producing Tumor
Hypertension, Epistaxis, Renal cortical adenoma, Glucocortocoid-insensitive primary hyperaldoster... ORPHA:231632
Cocaine Intoxication
Cerebral hemorrhage, Hypertension, Prolonged QT interval, Tubulointerstitial nephritis, Ventricul... ORPHA:90068
Gitelman Syndrome
Prolonged QT interval, Palpitations, Ventricular tachycardia, Hypocalciuria, Renal potassium wast... OMIM:263800
Renal Agenesis
Hypertension, Renal agenesis, Aplasia/Hypoplasia of the bladder, Bilateral renal agenesis, Ureter... ORPHA:411709
Primary Unilateral Adrenal Hyperplasia
Hypertension, Increased urinary potassium, Palpitations, Epistaxis, Glucocortocoid-insensitive pr... ORPHA:231580
Pseudohypoaldosteronism, Type Iic
Hypertension OMIM:614492
Pseudohypoaldosteronism, Type Iie
Hypertension OMIM:614496
Cholera
Abnormality of renal excretion, Hypovolemic shock, Decreased urine output, Tachycardia, Acute kid... ORPHA:173
Ileal Neuroendocrine Tumor
Right ventricular failure, Hydronephrosis, Tricuspid stenosis, Palpitations, Arterial occlusion, ... ORPHA:100078
Jejunal Neuroendocrine Tumor
Right ventricular failure, Hydronephrosis, Tricuspid stenosis, Palpitations, Arterial occlusion, ... ORPHA:100077
Congenital Hypothyroidism
Hypertension, Arrhythmia, Hypotension, Nephrolithiasis ORPHA:442
Diffuse Cutaneous Mastocytosis
Gastrointestinal hemorrhage, Hypotension ORPHA:79456
Familial Glucocorticoid Deficiency
Hypertrophic cardiomyopathy, Recurrent urinary tract infections, Renal salt wasting, Hypernatriur... ORPHA:361
Glycogen Storage Disease Ic
Spider hemangioma, Hypertension, Focal segmental glomerulosclerosis, Hyperlipidemia, Decreased gl... OMIM:232240
Neuroendocrine Tumor Of Stomach
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100075
Necrotizing Enterocolitis
Shock, Bradycardia, Hypotension ORPHA:391673
Familial Pseudohyperkalemia
Hypertension ORPHA:90044
Mastocytosis
Gastrointestinal hemorrhage, Arrhythmia, Telangiectasia of the skin, Hypotension ORPHA:98292
Hellp Syndrome
Cerebral hemorrhage, Hemoglobinuria, Acute kidney injury, Proteinuria, Internal hemorrhage, Hypot... ORPHA:244242
Autosomal Dominant Hypocalcemia
Nephrocalcinosis, Congestive heart failure, Hypermagnesiuria, Hypercalciuria, Arrhythmia, Hypoten... ORPHA:428
Acute Adrenal Insufficiency
Renal salt wasting, Orthostatic hypotension, Decreased urinary potassium, Myocardial infarction, ... ORPHA:95409
Aggressive Systemic Mastocytosis
Gastrointestinal hemorrhage, Portal hypertension, Hypotension ORPHA:98850
Staphylococcal Necrotizing Pneumonia
Shock, Hypotension ORPHA:36238
Fragile X-Associated Tremor/Ataxia Syndrome
Hypertension, Pollakisuria, Hypotension, Urinary bladder sphincter dysfunction ORPHA:93256
Neuroleptic Malignant Syndrome
Hypertension, Myoglobinuria, Hypertensive crisis, Tachycardia, Bradycardia, Urinary incontinence,... ORPHA:94093
Whipple Disease
Myocarditis, Pericarditis, Myocardial infarction, Gastrointestinal hemorrhage, Hypotension ORPHA:3452
Duodenal Neuroendocrine Tumor
Right ventricular failure, Hydronephrosis, Tricuspid stenosis, Palpitations, Melena, Pulmonic ste... ORPHA:100076
Congenital Enterovirus Infection
Myocarditis, Cardiomyopathy, Hypotension ORPHA:292
Beta-Ketothiolase Deficiency
Hypertension, Hypotension, Ketonuria ORPHA:134
Pde4D Haploinsufficiency Syndrome
Hypospadias, Hypotension ORPHA:439822
Bacterial Toxic-Shock Syndrome
Myocarditis, Shock, Tachycardia, Recurrent urinary tract infections, Glomerulonephritis, Renal in... ORPHA:36234
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypospadias, Penoscrotal hypospadias, Renal salt wasting, Hypotension, Decreased circulating cort... ORPHA:90791
Lujo Hemorrhagic Fever
Myocarditis, Shock, Subconjunctival hemorrhage, Bradycardia, Microscopic hematuria, Oliguria, Ren... ORPHA:319213
Sepsis In Premature Infants
Reversible renal failure, Tachycardia, Bradycardia, Oliguria, Hypotension ORPHA:90051
Pituitary Apoplexy
Hypertension, Increased circulating cortisol level, Hypotension ORPHA:95613
Poliomyelitis
Hypertension, Hypovolemic shock, Hypotension ORPHA:2912
Neuroendocrine Neoplasm Of Appendix
Tricuspid stenosis, Palpitations, Primary hypercortisolism, Hypotension, Heart murmur ORPHA:100079
Lysosomal Acid Lipase Deficiency
Renal salt wasting, Pulmonary arterial hypertension, Hypercholesterolemia, Xanthelasma, Steatorrh... ORPHA:275761
Bartter Syndrome, Type 1, Antenatal
Nephrocalcinosis, Increased urinary potassium, Hyperprostaglandinuria, Low-to-normal blood pressu... OMIM:601678
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hypotension, Decreased circulating cortisol level ORPHA:293978
Crimean-Congo Hemorrhagic Fever
Myocarditis, Subdural hemorrhage, Melena, Diffuse alveolar hemorrhage, Abnormal left ventricular ... ORPHA:99827
Gitelman Syndrome
Prominent U wave, Syncope, Tubulointerstitial nephritis, ST segment depression, Raynaud phenomeno... ORPHA:358
Hennekam-Beemer Syndrome
Arrhythmia, Telangiectasia of the skin, Hypotension ORPHA:2135
Late-Onset Isolated Acth Deficiency
Orthostatic hypotension, Hypotension, Decreased circulating cortisol level ORPHA:199299
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Prolonged QT interval, ST segment depression, Abnormal pulse pressure, Acute kid... ORPHA:466650
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
3-Hydroxy-3-Methylglutaric Aciduria
Dilated cardiomyopathy, Cardiac arrest, 3-Methylglutaric aciduria, Hypotension, Ketonuria ORPHA:20
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Renal salt wasting, Midshaft hypospadias, Urogenital sinus anomaly, Abnormal urine potassium conc... ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Renal salt wasting, Midshaft hypospadias, Urogenital sinus anomaly, Abnormal urine potassium conc... ORPHA:289548
Systemic Mastocytosis With Associated Hematologic Neoplasm
Syncope, Tachycardia, Hypotension ORPHA:98849
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension OMIM:608643
Bartter Syndrome, Type 2, Antenatal
Nephrocalcinosis, Increased urinary potassium, Hyperprostaglandinuria, Low-to-normal blood pressu... OMIM:241200
Leptospirosis
Pericarditis, Cellular urinary casts, Retinal hemorrhage, Subconjunctival hemorrhage, Pulmonary h... ORPHA:509
Alexander Disease
Sudden cardiac death, Hypertension, Hypotension ORPHA:58
Addison Disease
Orthostatic hypotension, Decreased urinary potassium, Renal salt wasting, Hypotension, Decreased ... ORPHA:85138
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Prolactinoma
Hypotension ORPHA:2965
Marburg Hemorrhagic Fever
Shock, Pericarditis, Subconjunctival hemorrhage, Tachycardia, Bradycardia, Hypovolemia, Internal ... ORPHA:99826
Tsh-Secreting Pituitary Adenoma
Hypertension, Ventricular arrhythmia, Palpitations, Congestive heart failure, Supraventricular ar... ORPHA:91347
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Shock, Renal salt wasting, Elevated urinary epinephrine, Long penis, Urogenital sinus anomaly, Hy... ORPHA:90794
Hepatocellular Carcinoma
Portal hypertension, Hypotension, Internal hemorrhage, Budd-Chiari syndrome ORPHA:88673
Acute Liver Failure
Shock, Intracranial hemorrhage, Acute kidney injury, Gastrointestinal hemorrhage, Hypotension ORPHA:90062
Non-Acquired Panhypopituitarism
Hypotension ORPHA:90695
Plague
Arrhythmia, Hematemesis, Tachycardia, Hypotension ORPHA:707
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension ORPHA:95494

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cyp4a14

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cyp4a14.

No publications found that use IMPC mice or data for Cyp4a14.

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MGI Allele Allele Type Produced
Cyp4a14tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cyp4a14tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cyp4a14tm41474(L1L2_st0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cyp4a14tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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