Gene Summary

Name:
polymerase (RNA) I polypeptide A
Synonyms:
2900087K15Rik,  3010014K16Rik,  194kDa,  Rpo1-4,  RPA194,  mRPA1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Polr1atm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right fundus

16 Images

Eye Morphology

VIP of left fundus

16 Images

Eye Morphology

VIP of left eye

16 Images

Eye Morphology

VIP of right eye

16 Images

Human diseases caused by Polr1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Polr1a by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Burn-Mckeown Syndrome
ORPHA:1200
Acrofacial Dysostosis, Cincinnati Type
OMIM:616462

The table below shows human diseases predicted to be associated to Polr1a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Burn-Mckeown Syndrome
ORPHA:1200
Acrofacial Dysostosis, Cincinnati Type
OMIM:616462

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Polr1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Polr1a.

No publications found that use IMPC mice or data for Polr1a.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Polr1atm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Polr1atm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Polr1atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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