Genes Phenotypes

Gene: Sema3f

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Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
MGI ID
MGI:1096347
Synonyms
Sema IV Semak
Viability
Homozygous - Subviable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (15) Measurements chart (220) All data table (373)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating serum albumin level Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 1.22×10-05
abnormal bone structure Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 4.41×10-06
abnormal gait Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 1.91×10-07
decreased bone mineral density Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 1.16×10-07
decreased bone mineral content Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 5.02×10-09
iris synechia Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 8.65×10-05
limb grasping Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 3.42×10-10
decreased total body fat amount Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 4.62×10-06
tremors Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 7.11×10-06
abnormal nail morphology Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 1.41×10-05
decreased circulating total protein level Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 1.98×10-05
decreased lean body mass Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 4.48×10-09
cataract Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 9.01×10-06
preweaning lethality, incomplete penetrance Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased circulating iron level Sema3ftm1b(EUCOMM)Hmgu HOM Early adult 2.42×10-06

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (6)
Cerebral Cortex expression
Striatum expression
Brain expression
Hippocampus expression
Vascular System expression
MA:0000185
MA:0000891
MA:0000168
MA:0000191
MA:0002718
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (1)
Trachea expression
Thyroid gland expression
MA:0000441
MA:0000129
immune system (1)
Thymus expression
MA:0000142
integumental system (1)
Skin expression
MA:0000151
nervous system (6)
Cerebral Cortex expression
Striatum expression
Brain expression
Hippocampus expression
Vascular System expression
MA:0000185
MA:0000891
MA:0000168
MA:0000191
MA:0002718
postnatal mouse (20)
Cerebral Cortex expression
Striatum expression
Brain expression
Hippocampus expression
Vascular System expression
MA:0000185
MA:0000891
MA:0000168
MA:0000191
MA:0002718
reproductive system (2)
Oviduct expression
MA:0000385
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Vascular System expression
Cartilage tissue no expression
Peripheral Nervous System expression
MA:0002718
MA:0000104
MA:0000218
trunk (10)
Kidney expression
MA:0000368
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (4/4) N/A
Ear 2  (1/504)  (2/4) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (4/4) N/A
Foot 2  (1/504)  (4/4) N/A
Forebrain 2  (1/504)  (4/4) N/A
Forelimb 2  (1/504)  (4/4) N/A
Hand 2  (1/503)  (4/4) N/A
Head 2  (5/504)  (4/4) N/A
Heart 2  (1/504)  (2/4) N/A
Hindbrain 2  (6/504)  (3/4) N/A
Hindlimb 2  (1/503)  (4/4) N/A
Liver 2  (1/504)  (1/4) N/A
Lung 2  (1/500)  (1/4) N/A
Mandibular process 2  (1/504)  (2/4) N/A
Maxillary process 2  (1/504)  (2/4) N/A
Midbrain 2  (1/504)  (4/4) N/A
Oral cavity 2  (1/504)  (2/4) N/A
Skin 2  (1/504)  (2/4) N/A
Tail 2  (1/504)  (4/4) N/A
Tail somite 2  (1/504)  (2/4) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
20 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Sema3ftm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Sema3ftm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp) Mice
Sema3ftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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