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Gene: Neurog2 MGI:109619

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

neurogenin 2

Synonyms:

Math4A, Atoh4, bHLHa8, ngn2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Neurog2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Neurog2 (0 diseases)
Human diseases predicted to be associated with Neurog2 (282 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Neurog2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Hereditary Liability to Pressure Palsies (HNPP)	Abnormal motor neuron morphology	DECIPHER:31
Spinal Muscular Atrophy, Segmental	Abnormal anterior horn cell morphology	OMIM:183020
Nodular Neuronal Heterotopia	Abnormality of neuronal migration	ORPHA:2149
Chudley-Mccullough Syndrome	Polymicrogyria, Cerebellar dysplasia, Hydrocephalus, Partial agenesis of the corpus callosum, Gra...	OMIM:604213
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Subcortical band heterotopia	OMIM:615411
Amyotrophic Lateral Sclerosis, Susceptibility To, 25	Amyotrophic lateral sclerosis	OMIM:617921
Charcot-Marie-Tooth syndrome type 1A (CMT1A)	Hypertrophic nerve changes, Abnormal motor neuron morphology, Decreased motor nerve conduction ve...	DECIPHER:29
Lissencephaly 1	Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Subcortical band heterotopia	OMIM:607432
Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia	Amyotrophic lateral sclerosis	OMIM:616208
Lissencephaly, X-Linked, 1	Death in infancy, Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Agenesis of corpus ...	OMIM:300067
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10	Type II lissencephaly, Neural tube defect, Cerebellar dysplasia	OMIM:615041
Lissencephaly 3	Polymicrogyria, Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Periventricular lamin...	OMIM:611603
Microlissencephaly	Polymicrogyria, Simplified gyral pattern, Subcortical heterotopia, Pachygyria, Lissencephaly, Cer...	ORPHA:1083
Sub-Cortical Nodular Heterotopia	Polymicrogyria, Agenesis of corpus callosum, Abnormality of neuronal migration, Subcortical heter...	ORPHA:101029
Primary Lateral Sclerosis, Juvenile	Pseudobulbar paralysis, Loss of ambulation, Abnormal upper motor neuron morphology, Dysphagia, De...	OMIM:606353
Primary Lateral Sclerosis, Adult, 1	Abnormal upper motor neuron morphology	OMIM:611637
Periventricular Nodular Heterotopia 8	Cerebellar vermis atrophy, Periventricular nodular heterotopia	OMIM:618185
Hereditary Motor And Sensory Neuropathy, Okinawa Type	Abnormality of the seventh cranial nerve, Inability to walk, Abnormal peripheral action potential...	ORPHA:90117
Congenital Arthrogryposis With Anterior Horn Cell Disease	Abnormal anterior horn cell morphology, Inability to walk, Facial diplegia, Paucity of anterior h...	OMIM:611890
Isolated Lissencephaly Type 1 Without Known Genetic Defects	Agyria, Pachygyria, Gray matter heterotopia	ORPHA:1084
Diencephalic-Mesencephalic Junction Dysplasia Syndrome 2	Decreased thalamic volume	OMIM:618646
Cobblestone Lissencephaly Without Muscular Or Ocular Involvement	Type II lissencephaly, Hydrocephalus, Occipital encephalocele, Gray matter heterotopia, Dysgyria,...	ORPHA:352682
Periventricular Heterotopia With Microcephaly, Autosomal Recessive	Periventricular nodular heterotopia, Periventricular heterotopia	OMIM:608097
Amyotrophic Lateral Sclerosis 23	Degeneration of anterior horn cells, Amyotrophic lateral sclerosis	OMIM:617839
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures	Abnormality of neuronal migration, Hydrocephalus	OMIM:618709
Band Heterotopia	Polymicrogyria, Hydrocephalus, Lateral ventricle dilatation, Gray matter heterotopia, Agenesis of...	OMIM:600348
Cortical Dysplasia, Complex, With Other Brain Malformations 10	Hypoplasia of the pons, Lissencephaly, Periventricular ribbonlike heterotopia, Cerebellar hypoplasia	OMIM:618677
Juvenile Primary Lateral Sclerosis	Dysphagia, Gait imbalance, Abnormal upper motor neuron morphology, Spastic gait	ORPHA:247604
Neurodevelopmental Disorder With Cerebellar Hypoplasia And Spasticity	Periventricular nodular heterotopia, Cerebellar hypoplasia	OMIM:618572
Amyotrophic Lateral Sclerosis 4, Juvenile	Difficulty walking, Diffuse axonal swelling, Atrophy of the spinal cord, Abnormal lower motor neu...	OMIM:602433
Amyotrophic Lateral Sclerosis, Juvenile, With Dementia	Amyotrophic lateral sclerosis	OMIM:205200
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome	Limb ataxia, Unsteady gait, Progressive cerebellar ataxia, Abnormal lower motor neuron morphology...	ORPHA:95434
Neuronopathy, Distal Hereditary Motor, Type Viib	Abnormal lower motor neuron morphology	OMIM:607641
Amyotrophic Lateral Sclerosis With Polyglucosan Bodies	Amyotrophic lateral sclerosis	OMIM:205250
Periventricular Nodular Heterotopia 6	Periventricular nodular heterotopia	OMIM:615544
Polyglucosan Body Neuropathy, Adult Form	Gait disturbance, Abnormal upper motor neuron morphology, Peripheral axonal neuropathy, Orthostat...	OMIM:263570
Acalvaria	Spina bifida, Hydrocephalus, Holoprosencephaly, Aplasia/Hypoplasia of the cerebellum, Abnormality...	ORPHA:945
Amyotrophic Lateral Sclerosis 19	Amyotrophic lateral sclerosis	OMIM:615515
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Motor axonal neuropathy, Sensory axonal neuropathy, Short stature, Amyotrophic lateral sclerosis,...	ORPHA:52430
Lissencephaly 5	Type II lissencephaly, Hydrocephalus, Occipital encephalocele, Gray matter heterotopia, Subcortic...	OMIM:615191
Mismatch Repair Cancer Syndrome 4	Agenesis of corpus callosum, Gray matter heterotopia	OMIM:619101
Coasy Protein-Associated Neurodegeneration	Abnormality of thalamus morphology	ORPHA:397725
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations	Polymicrogyria, Simplified gyral pattern, Gray matter heterotopia, Pachygyria, Lissencephaly, Abn...	OMIM:604317
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105500
Polymicrogyria Due To Tubb2B Mutation	Polymicrogyria, Hypoplasia of the pons, Lateral ventricle dilatation, Gray matter heterotopia, Pa...	ORPHA:300573
Amyotrophic Lateral Sclerosis 9	Amyotrophic lateral sclerosis	OMIM:611895
Microcephaly, Postnatal Progressive, With Seizures And Brain Atrophy	Decreased thalamic volume	OMIM:613668
Subependymal Nodular Heterotopia	Polymicrogyria, Partial agenesis of the corpus callosum, Myelomeningocele, Meningocele, Occipital...	ORPHA:101030
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	Abnormal lower motor neuron morphology, Waddling gait, Difficulty walking	OMIM:611067
Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive	Thalamic calcification	OMIM:618824
Dystonia 31	Dysphagia, Abnormal posturing, Difficulty walking	OMIM:619565
Hemimegalencephaly	Polymicrogyria, Abnormal neuron morphology, Gray matter heterotopia, Gliosis, Pachygyria	ORPHA:99802
Neurodevelopmental Disorder With Seizures And Brain Atrophy	Decreased thalamic volume	OMIM:619072
Classic Pantothenate Kinase-Associated Neurodegeneration	Inability to walk, Gait disturbance, Attention deficit hyperactivity disorder, Optic disc pallor,...	ORPHA:216866
Amyotrophic Lateral Sclerosis 11	Decreased nerve conduction velocity, Amyotrophic lateral sclerosis	OMIM:612577
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	Disinhibition, Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis	OMIM:616439
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3	Disinhibition, Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis	OMIM:616437
Basal Ganglia Calcification, Idiopathic, 7, Autosomal Recessive	Thalamic calcification	OMIM:618317
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2	Partial agenesis of the corpus callosum, Hypoplasia of the pons, Simplified gyral pattern, Cerebe...	OMIM:616171
Primary Lateral Sclerosis	Motor axonal neuropathy, Atrophy of the spinal cord, Abnormal lower motor neuron morphology, Cerv...	ORPHA:35689
Leukoencephalopathy With Dystonia And Motor Neuropathy	Focal T2 hyperintense thalamic lesion	OMIM:613724
Basal Ganglia Calcification, Idiopathic, 5	Thalamic calcification	OMIM:615483
Combined Oxidative Phosphorylation Deficiency 51	Focal T2 hyperintense thalamic lesion	OMIM:619057
Bilateral Striopallidodentate Calcinosis	Abnormality of neuronal migration	ORPHA:1980
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies	Abnormal cortical gyration, Polymicrogyria, Neonatal death	OMIM:619602
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome	Inability to walk, Difficulty walking, Abnormal lower motor neuron morphology, Dysphagia, Waddlin...	ORPHA:2590
Lissencephaly 6 With Microcephaly	Polymicrogyria, Partial agenesis of the corpus callosum, Microlissencephaly, Simplified gyral pat...	OMIM:616212
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2	T2 hypointense thalamus	OMIM:618193
Amyotrophic Lateral Sclerosis 21	Abnormal lower motor neuron morphology, Decreased nerve conduction velocity, Abnormal upper motor...	OMIM:606070
Alexander Disease Type I	Abnormal thalamic MRI signal intensity	ORPHA:363717
Frontotemporal Dementia With Motor Neuron Disease	Progressive cerebellar ataxia, Disinhibition, Abnormal lower motor neuron morphology, Abnormal up...	ORPHA:275872
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Gait disturbance, Disinhibition, Abnormal upper motor neuron morphology, Peripheral demyelination...	OMIM:221770
Tubulinopathy-Associated Dysgyria	Abnormality of thalamus morphology	ORPHA:467166
Leber Congenital Amaurosis	Encephalocele, Aplasia/Hypoplasia of the cerebellar vermis, Abnormality of neuronal migration	ORPHA:65
Amyotrophic Lateral Sclerosis 2, Juvenile	Ataxia, Difficulty walking, Abnormal lower motor neuron morphology, Abnormal upper motor neuron m...	OMIM:205100
Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type	Miscarriage, T2 hypointense thalamus	ORPHA:1947
Symmetrical Thalamic Calcifications	Abnormality of neuronal migration	ORPHA:1314
Congenital Muscular Dystrophy Without Intellectual Disability	Cerebellar cyst, Cerebellar atrophy, Pachygyria, Gray matter heterotopia	ORPHA:370980
3-Hydroxyisobutyric Aciduria	Abnormality of neuronal migration	OMIM:236795
Lissencephaly 7 With Cerebellar Hypoplasia	Death in infancy, Neonatal death, Cerebellar hypoplasia, Agyria, Lissencephaly, Agenesis of corpu...	OMIM:616342
Panhypophysitis	Abnormal thalamic MRI signal intensity, Increased circulating prolactin concentration, Gonadotrop...	ORPHA:95513
Poretti-Boltshauser Syndrome	Cerebellar dysplasia, Cerebellar cyst, Gray matter heterotopia, Dilated fourth ventricle, Cerebel...	OMIM:615960
Maternal Hyperthermia-Induced Birth Defects	Abnormality of neuronal migration	ORPHA:2216
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6	Dysphagia, Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Difficulty walking	OMIM:613954
Adenohypophysitis	Abnormal thalamic MRI signal intensity, Increased circulating prolactin concentration, Gonadotrop...	ORPHA:95512
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7	Encephalocele, Death in childhood, Type II lissencephaly, Polymicrogyria, Partial agenesis of the...	OMIM:614643
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	Simplified gyral pattern, Cerebellar vermis hypoplasia, Cerebellar hypoplasia, Periventricular he...	OMIM:618273
Mitochondrial Complex Iv Deficiency, Nuclear Type 3	Death in infancy, Focal T2 hyperintense thalamic lesion	OMIM:619046
Chiari Malformation Type Ii	Cervical myelopathy, Myelomeningocele, Spina bifida, Hydrocephalus, Gray matter heterotopia, Chia...	OMIM:207950
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development	Fusion of the left and right thalami	OMIM:617542
Oculoskeletodental Syndrome	Abnormality of thalamus morphology	ORPHA:557003
Autosomal Recessive Primary Microcephaly	Agenesis of corpus callosum, Pachygyria, Gray matter heterotopia	ORPHA:2512
Congenital Muscular Dystrophy With Cerebellar Involvement	Type II lissencephaly, Polymicrogyria, Hydrocephalus, Olivopontocerebellar hypoplasia, Hypoplasia...	ORPHA:370959
Lissencephaly Syndrome, Norman-Roberts Type	4-layered lissencephaly, Microlissencephaly, Agenesis of corpus callosum, Cerebellar atrophy, Abn...	ORPHA:89844
Amyotrophic Lateral Sclerosis 5, Juvenile	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:602099
Oculocerebrocutaneous Syndrome	Agenesis of corpus callosum, Dandy-Walker malformation, Orbital encephalocele, Gray matter hetero...	OMIM:164180
Joubert Syndrome 30	Cerebellar atrophy, Dandy-Walker malformation, Superior cerebellar dysplasia, Gray matter heterot...	OMIM:617622
Dystonia 1, Torsion, Autosomal Dominant	Dysphagia, Facial palsy, Inability to walk, Abnormal posturing	OMIM:128100
Neurocutaneous Melanocytosis	Meningocele, Death in infancy, Aplasia/Hypoplasia of the cerebellum, Chiari malformation, Dandy-W...	ORPHA:2481
Brain Small Vessel Disease 2	Polymicrogyria, Subcortical heterotopia	OMIM:614483
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 6	Abnormality of neuronal migration, Cerebellar hypoplasia, Pachygyria	OMIM:608840
Periventricular Nodular Heterotopia 1	Abnormality of neuronal migration, Cerebellar hypoplasia, Gray matter heterotopia	OMIM:300049
Spastic Paralysis, Infantile-Onset Ascending	Dysphagia, Abnormal lower motor neuron morphology	OMIM:607225
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia	Dysphagia, Axonal loss, Amyotrophic lateral sclerosis, Athetosis	OMIM:300857
Intellectual Disability-Facial Dysmorphism Syndrome Due To Setd5 Haploinsufficiency	Abnormality of thalamus morphology	ORPHA:404440
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments	Motor neuron atrophy, Falls, Abnormal neuron morphology, Short stepped shuffling gait, Spinocereb...	ORPHA:412066
Familial Acute Necrotizing Encephalopathy	Abnormality of thalamus morphology	ORPHA:88619
Huntington Disease-Like 1	Gait disturbance, Restlessness, Bradykinesia, Gait ataxia, Abnormal posturing, Dysmetria	ORPHA:157941
Neurodegeneration With Brain Iron Accumulation 4	Motor axonal neuropathy, Gait disturbance, Ataxia, Abnormal lower motor neuron morphology, Loss o...	OMIM:614298
Boucher-Neuhauser Syndrome	Gait ataxia, Abnormal upper motor neuron morphology, Ataxia	OMIM:215470
Walker-Warburg Syndrome	Abnormal cortical gyration, Polymicrogyria, Macrogyria, Hydrocephalus, Abnormality of neuronal mi...	ORPHA:899
Lethal Congenital Contracture Syndrome 1	Paucity of anterior horn motor neurons, Neonatal death	OMIM:253310
3P25.3 Microdeletion Syndrome	Abnormality of thalamus morphology	ORPHA:435638
Glutathionuria	Agenesis of corpus callosum, Gray matter heterotopia	OMIM:231950
New-Onset Refractory Status Epilepticus	Abnormal thalamic MRI signal intensity	ORPHA:363558
Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome	Decreased response to growth hormone stimulation test, Gonadotropin deficiency, Hypothalamic lute...	ORPHA:231720
Amyotrophic Lateral Sclerosis 1	Dysphagia, Pseudobulbar paralysis, Degeneration of anterior horn cells, Amyotrophic lateral scler...	OMIM:105400
Cach Syndrome	T2 hypointense thalamus	ORPHA:135
Juvenile Neuronal Ceroid Lipofuscinosis	Focal T2 hyperintense thalamic lesion	ORPHA:79264
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105550
Intellectual Developmental Disorder, X-Linked 12	Abnormal cerebellum morphology, Gliosis, Cerebellar vermis hypoplasia, Abnormality of neuronal mi...	OMIM:300957
Mohr-Tranebjaerg Syndrome	Dysphagia, Abnormal posturing	OMIM:304700
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type	Abnormality of neuronal migration	ORPHA:2204
Combined Oxidative Phosphorylation Defect Type 23	Abnormal thalamic MRI signal intensity	ORPHA:444013
Leptin Receptor Deficiency	Pituitary hypothyroidism, Decreased response to growth hormone stimulation test, Abnormal hypotha...	OMIM:614963
Amyotrophic Lateral Sclerosis 12 With Or Without Frontotemporal Dementia	Dysphagia, Loss of ambulation, Amyotrophic lateral sclerosis	OMIM:613435
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation	Abnormality of thalamus morphology	ORPHA:300570
Amyotrophic Lateral Sclerosis 16, Juvenile	Loss of ambulation, Amyotrophic lateral sclerosis	OMIM:614373
Progeria-Short Stature-Pigmented Nevi Syndrome	Abnormality of thalamus morphology	ORPHA:2959
Leigh Syndrome With Cardiomyopathy	Abnormality of thalamus morphology	ORPHA:70474
Congenital Osteogenesis Imperfecta-Microcephaly-Cataracts Syndrome	Abnormality of neuronal migration, Aplasia/Hypoplasia of the cerebellum	ORPHA:2772
Edinburgh Malformation Syndrome	Abnormality of neuronal migration, Hydrocephalus	ORPHA:1895
Sandhoff Disease, Infantile Form	Abnormal thalamic MRI signal intensity	ORPHA:309155
Machado-Joseph Disease Type 3	Progressive cerebellar ataxia, Abnormal lower motor neuron morphology, Spinocerebellar tract dege...	ORPHA:276244
Thanatophoric Dysplasia Type 2	Encephalocele, Holoprosencephaly, Abnormality of neuronal migration, Hydrocephalus	ORPHA:93274
Hydrocephalus, Congenital, 2, With Or Without Brain Or Eye Anomalies	Colpocephaly, Hydrocephalus, Communicating hydrocephalus, Simplified gyral pattern, Gray matter h...	OMIM:615219
Neuroferritinopathy	Abnormal thalamic MRI signal intensity, T2 hypointense thalamus	ORPHA:157846
Abcd Syndrome	Neonatal death, Abnormal auditory evoked potentials, Aganglionic megacolon, Total intestinal agan...	OMIM:600501
Combined Oxidative Phosphorylation Defect Type 7	Abnormal thalamic MRI signal intensity	ORPHA:254930
Spastic Paraplegia 9A, Autosomal Dominant	Gait disturbance, Abnormal upper motor neuron morphology, Short stature, Gait ataxia, Spastic gait	OMIM:601162
Vocal Cord And Pharyngeal Distal Myopathy	Unsteady gait, Difficulty walking, Decreased nerve conduction velocity, Amyotrophic lateral scler...	ORPHA:600
Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia	Gait disturbance, Amyotrophic lateral sclerosis	OMIM:608030
Japanese Encephalitis	Focal T2 hyperintense thalamic lesion, Abnormality of thalamus morphology	ORPHA:79139
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia	Disinhibition, Dysphagia, Amyotrophic lateral sclerosis	OMIM:612069
Sporadic Infantile Bilateral Striatal Necrosis	Gait disturbance, Titubation, Dysphagia, Bradykinesia, Gait ataxia, Abnormal posturing	ORPHA:225147
Frontotemporal Dementia	Polyphagia, Amyotrophic lateral sclerosis, Disinhibition	OMIM:600274
Rhombencephalosynapsis	Fusion of the left and right thalami	ORPHA:59315
Amyotrophic Lateral Sclerosis, Susceptibility To, 24	Dysphagia, Amyotrophic lateral sclerosis	OMIM:617892
Amyotrophic Lateral Sclerosis 18	Dysphagia, Amyotrophic lateral sclerosis	OMIM:614808
Infantile-Onset X-Linked Spinal Muscular Atrophy	Abnormal anterior horn cell morphology, Degeneration of anterior horn cells	ORPHA:1145
Mff-Related Encephalopathy Due To Mitochondrial And Peroxisomal Fission Defect	Abnormal thalamic MRI signal intensity	ORPHA:485421
Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome	Abnormal thalamic MRI signal intensity	ORPHA:70595
Pyruvate Dehydrogenase E1-Beta Deficiency	Agenesis of corpus callosum, Pachygyria, Cerebellar hypoplasia, Periventricular heterotopia	ORPHA:255138
Chronic Bilirubin Encephalopathy	Abnormal thalamic MRI signal intensity	ORPHA:529808
Acute Bilirubin Encephalopathy	Abnormal thalamic MRI signal intensity	ORPHA:529799
Methylmalonic Aciduria And Homocystinuria, Cblj Type	Lethargy, Abnormal posturing, Growth delay	OMIM:614857
Vici Syndrome	Hypoplasia of the pons, Death in infancy, Gray matter heterotopia, Cerebellar hypoplasia, Agenesi...	ORPHA:1493
Desmosterolosis	Abnormal cortical gyration, Polymicrogyria, Macrogyria, Hydrocephalus, Pachygyria, Lissencephaly,...	ORPHA:35107
Hypertelorism-Hypospadias-Polysyndactyly Syndrome	Encephalocele, Abnormal cortical gyration, Polymicrogyria, Macrogyria, Exencephaly, Pachygyria, L...	ORPHA:2211
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome	Abnormality of the diencephalon	ORPHA:2570
Holoprosencephaly 14	Partial agenesis of the corpus callosum, Hydrocephalus, Aqueductal stenosis, Alobar holoprosencep...	OMIM:619895
Joubert Syndrome	Encephalocele, Polymicrogyria, Hydrocephalus, Cerebellar vermis hypoplasia, Abnormality of neuron...	ORPHA:475
Cntnap2-Related Developmental And Epileptic Encephalopathy	Cerebellar vermis atrophy, Abnormality of neuronal migration, Abnormal neuron morphology	ORPHA:163681
Carnitine Palmitoyltransferase Ii Deficiency	Polymicrogyria, Hydrocephalus, Pachygyria, Agenesis of corpus callosum, Cerebellar vermis hypopla...	ORPHA:157
Periventricular Nodular Heterotopia 7	Polymicrogyria, Periventricular nodular heterotopia, Gray matter heterotopia	OMIM:617201
Leigh Syndrome	Abnormal thalamic MRI signal intensity	ORPHA:506
Hypomelanosis Of Ito	Gray matter heterotopia	OMIM:300337
Tetrasomy 18P	Abnormality of neuronal migration	ORPHA:3307
Cerebral Palsy, Spastic Quadriplegic, 3	Gray matter heterotopia	OMIM:617008
Acute Disseminated Encephalomyelitis	Abnormal thalamic MRI signal intensity	ORPHA:83597
Hydranencephaly	Dysgenesis of the thalamus, Thalamic edema, Atrophic pituitary gland	ORPHA:2177
Thanatophoric Dysplasia	Gray matter heterotopia, Hydrocephalus	ORPHA:2655
Thanatophoric Dysplasia, Type I	Gray matter heterotopia, Neonatal death, Hydrocephalus	OMIM:187600
Pseudo-Torch Syndrome 2	Lateral ventricle dilatation, Polymicrogyria, Cerebellar hypoplasia, Gray matter heterotopia	OMIM:617397
Aceruloplasminemia	Abnormal thalamic MRI signal intensity	ORPHA:48818
Neu-Laxova Syndrome	Abnormal cortical gyration, Polymicrogyria, Macrogyria, Spina bifida, Abnormality of neuronal mig...	ORPHA:2671
Joubert Syndrome With Oculorenal Defect	Encephalocele, Cerebellar vermis hypoplasia, Abnormality of neuronal migration, Hydrocephalus	ORPHA:2318
Developmental Delay With Variable Neurologic And Brain Abnormalities	Gray matter heterotopia	OMIM:619694
Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome	Abnormality of neuronal migration, Aplasia/Hypoplasia of the cerebellum	ORPHA:2518
Congenital Disorder Of Deglycosylation 2	Polymicrogyria, Partial agenesis of the corpus callosum, Gray matter heterotopia, Hypothalamic ha...	OMIM:619775
Alkuraya-Kucinskas Syndrome	Cerebellar dysplasia, Hydrocephalus, Gray matter heterotopia, Cerebellar hypoplasia, Lissencephal...	OMIM:617822
3C Syndrome	Hydrocephalus, Death in infancy, Aplasia/Hypoplasia of the cerebellum, Dandy-Walker malformation,...	ORPHA:7
Neonatal Adrenoleukodystrophy	Abnormality of neuronal migration	ORPHA:44
Galloway-Mowat Syndrome	Aqueductal stenosis, Pachygyria, Abnormality of neuronal migration	ORPHA:2065
Meningioma	Focal T2 hypointense thalamic lesion, Increased circulating prolactin concentration, Neoplasm of ...	ORPHA:2495
Tay-Sachs Disease	Abnormal thalamic MRI signal intensity	ORPHA:845
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia	Fusion of the left and right thalami	OMIM:619306
Ventriculomegaly With Cystic Kidney Disease	Gray matter heterotopia, Hydrocephalus	OMIM:219730
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 5	Amyotrophic lateral sclerosis	OMIM:619141
Laryngotracheoesophageal Cleft Type 4	Abnormal lower motor neuron morphology	ORPHA:93941
Leprosy	Abnormality of the seventh cranial nerve, Steppage gait, Abnormal autonomic nervous system physio...	ORPHA:548
Holoprosencephaly-Caudal Dysgenesis Syndrome	Abnormality of the diencephalon	ORPHA:2165
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13	Type II lissencephaly, Agenesis of cerebellar vermis, Hydrocephalus, Communicating hydrocephalus,...	OMIM:615287
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 2	Dysphagia, Amyotrophic lateral sclerosis, Ataxia	OMIM:615911
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Polymicrogyria, Hydrocephalus, Pachygyria, Agenesis of corpus callosum, Cerebellar vermis hypopla...	ORPHA:228308
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Hydrocephalus, Chiari type I malformation, Cerebellar hypoplasia, Agenesis of corpus callosum, Da...	OMIM:618476
Amyotrophic Lateral Sclerosis 8	Dysphagia, Loss of ambulation, Amyotrophic lateral sclerosis	OMIM:608627
Li-Ghorbani-Weisz-Hubshman Syndrome	Periventricular heterotopia	OMIM:618974
Peroxisome Biogenesis Disorder 13A (Zellweger)	Gray matter heterotopia, Polymicrogyria, Neonatal death	OMIM:614887
Juvenile Amyotrophic Lateral Sclerosis	Inability to walk, Ataxia, Difficulty walking, Tip-toe gait, Amyotrophic lateral sclerosis, Head ...	ORPHA:300605
16P13.11 Microdeletion Syndrome	Holoprosencephaly, Abnormality of neuronal migration, Agenesis of corpus callosum	ORPHA:261236
Neurodevelopmental Disorder With Neuromuscular And Skeletal Abnormalities	Periventricular heterotopia, Colpocephaly, Hydrocephalus	OMIM:619833
Amyotrophic Lateral Sclerosis 20	Amyotrophic lateral sclerosis	OMIM:615426
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome	Thalamic hemorrhage	ORPHA:464321
Fragile X Syndrome	Periventricular heterotopia	OMIM:300624
Joubert Syndrome With Hepatic Defect	Hydrocephalus, Occipital encephalocele, Aplasia/Hypoplasia of the cerebellum, Cerebellar vermis h...	ORPHA:1454
Methylmalonate Semialdehyde Dehydrogenase Deficiency	Lateral ventricle dilatation, Periventricular heterotopia	OMIM:614105
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities	Frontal polymicrogyria, Gray matter heterotopia, Neonatal death, Pachygyria, Cerebellar vermis hy...	OMIM:620024
Progressive Non-Fluent Aphasia	Abnormal lower motor neuron morphology, Restlessness	ORPHA:100070
Man1B1-Cdg	Cerebellar hypoplasia, Periventricular heterotopia	ORPHA:397941
Thanatophoric Dysplasia Type 1	Gray matter heterotopia, Hydrocephalus	ORPHA:1860
Periventricular Nodular Heterotopia	Periventricular heterotopia	ORPHA:98892
Amyotrophic Lateral Sclerosis	Motor neuron atrophy, Amyotrophic lateral sclerosis, Agitation	ORPHA:803
Unilateral Polymicrogyria	Pseudobulbar paralysis, Abnormal posturing, Giant somatosensory evoked potentials	ORPHA:268943
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Polymicrogyria, Death in infancy, Abnormality of neuronal migration, Agenesis of corpus callosum	OMIM:608836
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency	Polymicrogyria, Olivopontocerebellar hypoplasia, Hypoplasia of the pons, Lobar holoprosencephaly,...	ORPHA:468631
Hereditary Cryohydrocytosis With Reduced Stomatin	Decreased thalamic volume	ORPHA:168577
Craniopharyngioma	Hypopituitarism, Increased circulating prolactin concentration, Abnormal hypothalamus morphology,...	ORPHA:54595
Coffin-Lowry Syndrome	Death in early adulthood, Abnormality of neuronal migration, Aplasia/Hypoplasia of the cerebellum	ORPHA:192
Radio-Tartaglia Syndrome	Agenesis of corpus callosum, Gray matter heterotopia	OMIM:619312
Holoprosencephaly 7	Fusion of the left and right thalami, Panhypopituitarism	OMIM:610828
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome	Abnormality of neuronal migration	ORPHA:2063
Bickerstaff Brainstem Encephalitis	Abnormal thalamic MRI signal intensity	ORPHA:79138
Aicardi Syndrome	Polymicrogyria, Partial agenesis of the corpus callosum, Spina bifida, Lateral ventricle dilatati...	OMIM:304050
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	Agenesis of corpus callosum, Interhypothalamic adhesion, Periventricular heterotopia	OMIM:618929
Oculocerebral Hypopigmentation Syndrome, Preus Type	Abnormality of the diencephalon	ORPHA:2720
6Q Terminal Deletion Syndrome	Colpocephaly, Polymicrogyria, Gray matter heterotopia, Cerebellar hypoplasia, Abnormality of neur...	ORPHA:75857
Van Maldergem Syndrome 1	Periventricular nodular heterotopia, Simplified gyral pattern, Gray matter heterotopia, Pachygyri...	OMIM:601390
Acromelic Frontonasal Dysostosis	Encephalocele, Periventricular nodular heterotopia, Retrocerebellar cyst, Gray matter heterotopia...	OMIM:603671
Cerebrofacioarticular Syndrome	Dysplastic corpus callosum, Agenesis of corpus callosum, Cerebellar vermis hypoplasia, Gray matte...	ORPHA:314679
Orofaciodigital Syndrome Type 6	Hypothalamic hamartoma, Cerebellar vermis hypoplasia, Abnormality of neuronal migration	ORPHA:2754
Pagod Syndrome	Encephalocele, Spina bifida, Meningocele, Death in infancy, Abnormality of neuronal migration	ORPHA:991
9Q21.13 Microdeletion Syndrome	Gray matter heterotopia	ORPHA:531151
Vici Syndrome	Dysphagia, Postnatal growth retardation, Abnormal posturing	OMIM:242840
Genitourinary And/Or Brain Malformation Syndrome	Colpocephaly, Polymicrogyria, Holoprosencephaly, Dysplastic corpus callosum, Gray matter heteroto...	OMIM:618820
Ane Syndrome	Motor neuron atrophy, Delayed puberty, Short stature	ORPHA:157954
Multiple Acyl-Coa Dehydrogenase Deficiency	Gliosis, Gray matter heterotopia	ORPHA:26791
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Death in childhood, Abnormal cortical gyration, Polymicrogyria, Colpocephaly, Agenesis of cerebel...	OMIM:210710
Orofaciodigital Syndrome I	Abnormal cortical gyration, Myelomeningocele, Hydrocephalus, Cerebellar cyst, Gray matter heterot...	OMIM:311200
Bohring-Opitz Syndrome	Agenesis of corpus callosum, Dandy-Walker malformation, Gray matter heterotopia	OMIM:605039
Bilateral Perisylvian Polymicrogyria	Cerebellar dysplasia, Bilateral perisylvian polymicrogyria, Perisylvian predominant thick cortex ...	ORPHA:98889
Alg11-Cdg	Gray matter heterotopia	ORPHA:280071
Neurodevelopmental Disorder With Hypotonia, Neonatal Respiratory Insufficiency, And Thermodysregulation	Gray matter heterotopia	OMIM:618797
Orofaciodigital Syndrome Xvi	Gray matter heterotopia	OMIM:617563
Hydrolethalus Syndrome 1	Abnormal cortical gyration, Anencephaly, Stillbirth, Gray matter heterotopia, Agenesis of corpus ...	OMIM:236680
Holoprosencephaly	Encephalocele, Spinal dysraphism, Hydrocephalus, Holoprosencephaly, Aplasia/Hypoplasia of the cer...	ORPHA:2162
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Gray matter heterotopia	OMIM:608624
Sandifer Syndrome	Abnormal posturing	ORPHA:71272
Miller-Dieker Lissencephaly Syndrome	Lissencephaly, Gray matter heterotopia, Pachygyria, Agyria	OMIM:247200
Opitz-Kaveggia Syndrome	Gray matter heterotopia, Partial agenesis of the corpus callosum, Hydrocephalus	OMIM:305450
Duplication Of The Pituitary Gland	Abnormality of the pituitary gland, Abnormal hypothalamus morphology	ORPHA:314621
Skeletal Dysplasia, Mild, With Joint Laxity And Advanced Bone Age	Periventricular heterotopia	OMIM:618870
Peroxisome Biogenesis Disorder 1A (Zellweger)	Death in childhood, Polymicrogyria, Gray matter heterotopia	OMIM:214100
Van Maldergem Syndrome 2	Periventricular nodular heterotopia, Subcortical band heterotopia, Gray matter heterotopia	OMIM:615546
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome	Holoprosencephaly, Abnormality of neuronal migration	ORPHA:3186
16Q24.3 Microdeletion Syndrome	Colpocephaly, Periventricular heterotopia	ORPHA:261250
Arima Syndrome	Agenesis of cerebellar vermis, Gray matter heterotopia, Occipital meningocele, Dilated fourth ven...	OMIM:243910
Orofaciodigital Syndrome Xiv	Polymicrogyria, Partial agenesis of the corpus callosum, Simplified gyral pattern, Occipital ence...	OMIM:615948
Neuromuscular Oculoauditory Syndrome	Agenesis of corpus callosum, Periventricular heterotopia	OMIM:618733
Mismatch Repair Cancer Syndrome 1	Agenesis of corpus callosum, Gray matter heterotopia	OMIM:276300
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8	Amyotrophic lateral sclerosis	OMIM:619132
Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia	Amyotrophic lateral sclerosis	OMIM:619133
Koolen-De Vries Syndrome	Gray matter heterotopia	OMIM:610443
Fontaine Progeroid Syndrome	Hydrocephalus, Death in infancy, Neonatal death, Gray matter heterotopia, Cerebellar hypoplasia, ...	OMIM:612289
Periventricular Nodular Heterotopia 9	Polymicrogyria, Periventricular nodular heterotopia, Gray matter heterotopia	OMIM:618918
Autosomal Recessive Spastic Paraplegia Type 11	Hypothalamic atrophy	ORPHA:2822
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome	Gray matter heterotopia	ORPHA:453499
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation	Abnormality of neuronal migration	ORPHA:464311
Idiopathic Camptocormia	Syringomyelia, Myelitis, Amyotrophic lateral sclerosis	ORPHA:1320
Smith-Lemli-Opitz Syndrome	Colpocephaly, Partial agenesis of the corpus callosum, Hydrocephalus, Holoprosencephaly, Death in...	OMIM:270400
Amoebiasis Due To Free-Living Amoebae	Abnormal hypothalamus morphology	ORPHA:68
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation	Agenesis of corpus callosum, Gray matter heterotopia	ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion	Agenesis of corpus callosum, Gray matter heterotopia	ORPHA:352665
Nijmegen Breakage Syndrome	Abnormality of neuronal migration	ORPHA:647
Williams Syndrome	Death in early adulthood, Abnormality of the diencephalon	ORPHA:904
Orofaciodigital Syndrome Type 14	Periventricular heterotopia, Dandy-Walker malformation, Partial agenesis of the corpus callosum, ...	ORPHA:434179
Norrie Disease	Abnormality of the diencephalon	ORPHA:649
Genitopatellar Syndrome	Agenesis of corpus callosum, Colpocephaly, Pachygyria, Periventricular heterotopia	OMIM:606170
Proteus Syndrome	Gray matter heterotopia	ORPHA:744
Mowat-Wilson Syndrome Due To Monosomy 2Q22	Polymicrogyria, Agenesis of cerebellar vermis, Enlarged cerebellum, Lateral ventricle dilatation,...	ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Polymicrogyria, Agenesis of cerebellar vermis, Enlarged cerebellum, Lateral ventricle dilatation,...	ORPHA:261552
Mowat-Wilson Syndrome	Polymicrogyria, Agenesis of cerebellar vermis, Enlarged cerebellum, Agenesis of corpus callosum, ...	ORPHA:2152

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Neurog2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Neurog2.

No publications found that use IMPC mice or data for Neurog2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Neurog2^{tm1(KOMP)Wtsi}	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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