Genes Phenotypes

Gene: Atp6v1b2

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Name
ATPase, H+ transporting, lysosomal V1 subunit B2
MGI ID
MGI:109618
Synonyms
Atp6b2 HO57
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (223) All data table (370)
Expression & images (29) Disease models (0) Histopathology (2) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Atp6v1b2tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased mean corpuscular volume Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 7.57×10-06
embryonic lethality prior to tooth bud stage Atp6v1b2tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased mean corpuscular hemoglobin concentration Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 3.12×10-06
decreased mean corpuscular hemoglobin Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 4.28×10-16
decreased hemoglobin content Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 1.36×10-08
small adrenal glands Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 0.00
embryonic lethality prior to organogenesis Atp6v1b2tm1b(KOMP)Wtsi HOM E9.5 0.00
small lymph nodes Atp6v1b2tm1b(KOMP)Wtsi HET Early adult 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 5  (1/61) N/A
Brain 6  (6/504) N/A
Central nervous system ganglion 5  (1/70) N/A
Ear 6  (1/504) N/A
Embryo 6  (1/505)  (4/6) N/A
Eye 6  (1/504) N/A
Foot 6  (1/504) N/A
Forebrain 6  (1/504) N/A
Forelimb 6  (1/504) N/A
Gut 5  (1/56) N/A
Hand 6  (1/503) N/A
Head 6  (5/504) N/A
Heart 6  (1/504)  (4/6) N/A
Hindbrain 6  (6/504) N/A
Hindlimb 6  (1/503) N/A
Liver 6  (1/504) N/A
Lung 6  (1/500) N/A
Mandibular process 6  (1/504) N/A
Maxillary process 6  (1/504) N/A
Midbrain 6  (1/504) N/A
Nose 5  (1/70) N/A
Oral cavity 6  (1/504) N/A
Skeleton 5  (1/70) N/A
Skin 6  (1/504) N/A
Spinal cord 5  (1/69) N/A
Tail 6  (1/504) N/A
Tail somite 6  (1/504) N/A
Trachea 5  (1/56) N/A
Urinary system 5  (1/56)  (4/5) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
86 Images
X-ray: XRay Images Whole Body Dorso Ventral
16 Images
X-ray: XRay Images Whole Body Lateral Orientation
32 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Hind Leg and Hip
16 Images
Gross Pathology and Tissue Collection
8 Images
Eye Morphology: Images Slit Lamp
7 Images
Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Spleen - MPATH diagnostic term extramedullary hemopoiesis Atp6v1b2tm1b(KOMP)Wtsi HET Early adult
Spleen - hyperplasia Atp6v1b2tm1b(KOMP)Wtsi HET Early adult

 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Atp6v1b2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Atp6v1b2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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