Dsp | desmoplakin
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Embryo Nervous system Mortality/aging Cardiovascular system Craniofacial
16 No significant impact
2 Not tested
Data collections
Gene metrics:11Significant phenotypes
16Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal neural tube morphology | 1 supporting dataset | Dspem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| enlarged lymph nodes | 2 supporting datasets | Dspem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal neural tube closure | 1 supporting dataset | Dspem1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Dspem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Dspem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Dspem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Dspem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Dspem1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Dspem1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Dspem1(IMPC)Mbp | homozygote | E15.5 | N/A * |
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Human diseases caused by Dsp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dsp.
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| Dspem1(IMPC)Mbp | Exon Deletion | | mouse |
| Dsptm356609(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |