Gene: Faah MGI:109609

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Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

fatty acid amide hydrolase

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Faah mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Faah by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Severe Primary Trimethylaminuria
Negative affectivity, Low self esteem, Aggressive behavior, Depression, Emotional lability, Anxiety ORPHA:468726
Intellectual Developmental Disorder, X-Linked 63
Microcephaly, Anxiety OMIM:300387
Mental Retardation, Autosomal Recessive 25
Anxiety OMIM:614346
Panic Disorder 1
Anxiety OMIM:167870
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Childhood-Onset Benign Chorea With Striatal Involvement
Anxiety, Abnormal corpus striatum morphology, Striatal T2 hyperintensity ORPHA:494541
Geniospasm 1
Anxiety OMIM:190100
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia, Lethargy OMIM:610006
Spontaneous Periodic Hypothermia
Tremor, Hypothermia, Ataxia ORPHA:29822
Hereditary Central Diabetes Insipidus
Polydipsia, Fever ORPHA:30925
Primary Erythromelalgia
Hypothermia ORPHA:90026
Chorea, Benign Hereditary
Anxiety OMIM:118700
Developmental And Epileptic Encephalopathy 78
Chorea, Hypothermia OMIM:618557
Claustrophobia, Depression, Agoraphobia, Separation insecurity, Emotional lability, Impulsivity, ... ORPHA:66624
Idiopathic Congenital Hypothyroidism
Hypothermia, Lethargy ORPHA:95717
Familial Cold Urticaria
Polydipsia, Fever, Dysesthesia ORPHA:47045
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Menkes Disease
Hypothermia OMIM:309400
Aromatic L-Amino Acid Decarboxylase Deficiency
Temperature instability, Lethargy, Blepharospasm, Exaggerated startle response, Torticollis, Ocul... OMIM:608643
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Dysdiadochokinesis, Tremor, Gait ataxia, Dysphagia, Intention tremor, He... ORPHA:99027
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
Leptin Receptor Deficiency
Aggressive behavior, Decreased response to growth hormone stimuation test, Pituitary hypothyroidi... OMIM:614963
Familial Thyroid Dyshormonogenesis
Hypothermia, Lethargy ORPHA:95716
Permanent Congenital Hypothyroidism
Hypothermia ORPHA:226292
Meningococcal Meningitis
Hypothermia, Lethargy, Fever ORPHA:33475
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Central Diabetes Insipidus
Polydipsia, Fever ORPHA:178029
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Inability to walk, Unsteady gait, Abnormality of temperature regulation, Hypothermia, Fever OMIM:618493
Yellow Fever
Malignant hyperthermia, Hypothermia, Lethargy, Fever ORPHA:99829
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia ORPHA:226313
Mitochondrial Dna-Associated Leigh Syndrome
Gait ataxia, Dysphagia, Chorea, Ataxia, Hypothermia, Fever ORPHA:255210
Genetic Transient Congenital Hypothyroidism
Hypothermia, Lethargy ORPHA:226316
Diabetes Insipidus, Neurohypophyseal Type
Polydipsia OMIM:304900
Congenital Hypothyroidism
Hypothermia, Paresthesia ORPHA:442
Congenital Enterovirus Infection
Hypothermia, Fever ORPHA:292
Carnitine-Acylcarnitine Translocase Deficiency
Hypothermia, Lethargy ORPHA:159
Early-Onset Schizophrenia
Low self esteem, Depression, Abnormal emotion/affect behavior, Impairment in personality function... ORPHA:96369
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia, Unexplained fevers OMIM:125800
Alexander Disease
Tremor, Dysphagia, Chorea, Ataxia, Hypothermia ORPHA:58
Diabetes Insipidus, Nephrogenic, X-Linked
Polydipsia, Unexplained fevers OMIM:304800
Hypothyroidism Due To Tsh Receptor Mutations
Hypothermia, Lethargy ORPHA:90673
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
3-Hydroxy-3-Methylglutaric Aciduria
Hypothermia, Ataxia, Lethargy, Fever ORPHA:20
Neuroleptic Malignant Syndrome
Tremor, Dysphagia, Chorea, Hypothermia, Fever ORPHA:94093
Hereditary Sensory And Autonomic Neuropathy Type 4
Dysphagia, Pain insensitivity, Impaired temperature sensation, Painless fractures due to injury, ... ORPHA:642
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia, Lethargy ORPHA:26793
Isolated Thyroid-Stimulating Hormone Deficiency
Hypothermia, Lethargy, Attention deficit hyperactivity disorder ORPHA:90674
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
East Syndrome
Polydipsia, Salt craving, Ataxia, Action tremor ORPHA:199343
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Tbck-Related Intellectual Disability Syndrome
Inability to walk, Hypothermia ORPHA:488632
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polyphagia, Hypothermia, Impaired pain sensation, Polydipsia, Fever ORPHA:293987
Ethylene Glycol Poisoning
Hypothermia, Ataxia ORPHA:31826
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia, Lethargy, Ataxia ORPHA:79282
Complex Regional Pain Syndrome
Trophic changes related to pain, Somatic sensory dysfunction, Dysesthesia, Allodynia ORPHA:83452
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Ochoa Syndrome
Polydipsia ORPHA:2704
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Dysdiadochokinesis, Ataxia, Salt craving, Intention tremor, Polydipsia OMIM:612780
Familial Hyperaldosteronism Type I
Polydipsia ORPHA:403
Nephrogenic Diabetes Insipidus
Polydipsia, Fever ORPHA:223
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Dystonia, Hypothermia, Unsteady gait ORPHA:17
Polydipsia, Fever ORPHA:213
Menkes Disease
Chorea, Hypothermia ORPHA:565
Helix Syndrome
Heat intolerance, Polydipsia OMIM:617671
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothermia, Lethargy OMIM:218700
Gitelman Syndrome
Paresthesia, Ataxia, Salt craving, Recurrent fever, Polydipsia OMIM:263800
Whipple Disease
Polydipsia, Ataxia, Fever ORPHA:3452
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Athetosis, Polydipsia ORPHA:369929
Nephronophthisis 4
Polydipsia OMIM:606966
Familial Hyperaldosteronism Type Iii
Polydipsia ORPHA:251274
Hyperaldosteronism, Familial, Type Iii
Polydipsia OMIM:613677
Pediatric-Onset Graves Disease
Tremor, Polydipsia, Polyphagia ORPHA:525731
Occipital Horn Syndrome
Dysphagia, Hypothermia ORPHA:198
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Inability to walk, Dystonia, Exaggerated startle response, Hypothermia, Broad-based gait ORPHA:438213
Nephronophthisis 3
Polydipsia OMIM:604387
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Lethargy ORPHA:226307
Nephronophthisis 1
Polydipsia OMIM:256100
Anterior Cutaneous Nerve Entrapment Syndrome
Somatic sensory dysfunction, Hyperesthesia, Impaired tactile sensation, Allodynia ORPHA:51890
Primary Unilateral Adrenal Hyperplasia
Polydipsia ORPHA:231580
Apparent Mineralocorticoid Excess
Polydipsia ORPHA:320
Trigeminal Neuralgia
Allodynia ORPHA:221091
Nephronophthisis 11
Polydipsia OMIM:613550
Duplication Of The Pituitary Gland
Self-mutilation, Abnormality of the pituitary gland, Abnormal hypothalamus morphology, Microcepha... ORPHA:314621
Erdheim-Chester Disease
Polydipsia, Ataxia, Fever ORPHA:35687
Renal Hypoplasia
Polydipsia ORPHA:93101
Brain-Lung-Thyroid Syndrome
Abnormal drinking behavior, Chorea, Intention tremor, Ataxia, Abnormal eating behavior, Unexplain... ORPHA:209905
Septo-Optic Dysplasia Spectrum
Polydipsia ORPHA:3157
Pituitary Dermoid And Epidermoid Cysts
Polydipsia ORPHA:91351
Hyperparathyroidism, Neonatal Severe
Polydipsia OMIM:239200
Neurotrophic Keratopathy
Allodynia ORPHA:137596
Primary Parathyroid Hyperplasia
Dysphagia, Polydipsia ORPHA:99878
Wolfram Syndrome
Polydipsia, Ataxia ORPHA:3463
Hypothermia, Fever ORPHA:797
Polydipsia ORPHA:95513
Abnormal hypothalamus morphology, Enlarged pituitary gland, Pituitary hypothyroidism, Hypopituita... ORPHA:54595
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Rabson-Mendenhall Syndrome
Polydipsia ORPHA:769
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Dysphagia, Polydipsia ORPHA:537
Bartter Syndrome, Type 2, Antenatal
Polydipsia, Paresthesia, Fever OMIM:241200
Infantile Nephropathic Cystinosis
Polydipsia ORPHA:411629
Hyperparathyroidism-Jaw Tumor Syndrome
Dysphagia, Polydipsia ORPHA:99880
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Parathyroid Carcinoma
Dysphagia, Polydipsia ORPHA:143
Gitelman Syndrome
Polydipsia, Salt craving, Paresthesia ORPHA:358
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia ORPHA:93111
Cystinosis, Nephropathic
Dysphagia, Polydipsia, Oral-pharyngeal dysphagia OMIM:219800
Juvenile Nephropathic Cystinosis
Polydipsia ORPHA:411634
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Faah

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Faah.

No publications found that use IMPC mice or data for Faah.

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MGI Allele Allele Type Produced
Faahem1(IMPC)H Exon Deletion Mice
Faahtm367406(L1L2_Bact_P) Targeting vectors

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