Tuft1 | tuftelin 1

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Vision/eye

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat appearance6 supporting datasetsTuft1tm1a(KOMP)WtsihomozygoteEarly adult8.76x10-21 
decreased circulating alkaline phosphatase level1 supporting datasetTuft1tm1a(KOMP)WtsihomozygoteEarly adult3.37x10-5 
improved glucose tolerance1 supporting datasetTuft1tm1a(KOMP)WtsihomozygoteEarly adult6.05x10-6 
abnormal vibrissa morphology1 supporting datasetTuft1tm1a(KOMP)WtsihomozygoteEarly adult6.9x10-6 
abnormal eyelid morphology1 supporting datasetTuft1tm1a(KOMP)WtsihomozygoteEarly adult3.6x10-5 
decreased circulating HDL cholesterol level1 supporting datasetTuft1tm1a(KOMP)WtsihomozygoteEarly adult5.35x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tuft1tm115823(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Tuft1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tuft1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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