Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
a disintegrin and metallopeptidase domain 10
Synonyms:
1700031C13Rik,  kuz,  kuzbanian

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adam10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Adam10 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Reticulate Acropigmentation Of Kitamura
OMIM:615537

The table below shows human diseases predicted to be associated to Adam10 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lambert Syndrome
Branchial anomaly, Aplasia/Hypoplasia of the cerebellum, Ventricular septal defect, Intrauterine ... ORPHA:1296
X-Linked Mandibulofacial Dysostosis
Abnormal mitral valve morphology, Webbed neck, Pulmonic stenosis, Branchial anomaly, Microcephaly ORPHA:1131
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst, Microcephaly ORPHA:435938
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Bicuspid aortic valve, Ventricular septal defect, Intrauterine growth retardation, Atrioventricul... ORPHA:453499
Holoprosencephaly
Dandy-Walker malformation, Ventricular septal defect, Holoprosencephaly, Branchial anomaly, Aplas... ORPHA:2162
Craniofacial Microsomia
Ventricular septal defect, Patent ductus arteriosus, Branchial anomaly, Hydrocephalus, Tetralogy ... OMIM:164210
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula ORPHA:50815
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula, Abnormal cerebral morphology OMIM:113650
Distal 22Q11.2 Microduplication Syndrome
Ventricular septal defect, Branchial fistula, Webbed neck, Tricuspid valve prolapse, Patent ductu... ORPHA:261337
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Bicuspid aortic valve, Ventricular septal defect, Abnormal heart morphology, Cystic hygroma, Bran... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Bicuspid aortic valve, Ventricular septal defect, Abnormal heart morphology, Cystic hygroma, Bran... ORPHA:352665
Bor Syndrome
Branchial cyst ORPHA:107
Distal 22Q11.2 Microdeletion Syndrome
Ventricular septal defect, Truncus arteriosus, Intrauterine growth retardation, Branchial fistula... ORPHA:261330
Oligomeganephronia
Branchial cyst, Secundum atrial septal defect ORPHA:2260
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Treacher-Collins Syndrome
Branchial fistula, Patent ductus arteriosus ORPHA:861
8Q24.3 Microdeletion Syndrome
Branchial cyst, Complete atrioventricular canal defect, Ventricular septal defect, Truncus arteri... ORPHA:508488
Branchiooculofacial Syndrome
Intrauterine growth retardation, Agenesis of cerebellar vermis, Branchial anomaly, Low posterior ... OMIM:113620
Reticulate Acropigmentation Of Kitamura
OMIM:615537

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adam10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adam10.

No publications found that use IMPC mice or data for Adam10.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Adam10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adam10tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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