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Gene: Adam10 MGI:109548

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
a disintegrin and metallopeptidase domain 10
Synonyms:
1700031C13Rik,  kuz,  kuzbanian

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adam10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Adam10 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Reticulate Acropigmentation Of Kitamura
OMIM:615537

The table below shows human diseases predicted to be associated to Adam10 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lambert Syndrome
Branchial anomaly, Intrauterine growth retardation, Aplasia/Hypoplasia of the cerebellum, Ventric... ORPHA:1296
Verheij Syndrome
Short neck, Ventricular septal defect, Intrauterine growth retardation, Branchial cyst, Truncus a... OMIM:615583
X-Linked Mandibulofacial Dysostosis
Branchial anomaly, Webbed neck, Abnormal mitral valve morphology, Pulmonic stenosis ORPHA:1131
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Increased nuchal translucency, Cystic hygroma, Atrial septal defect, Ventricular septal defect, A... ORPHA:453499
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Branchiogenic Deafness Syndrome
Branchial fistula, Branchial cyst ORPHA:50815
Holoprosencephaly
Encephalocele, Abnormal pulmonary valve morphology, Spinal dysraphism, Ventricular septal defect,... ORPHA:2162
Distal 22Q11.2 Microduplication Syndrome
Ventricular septal defect, Hydrocephalus, Tricuspid valve prolapse, Low posterior hairline, Branc... ORPHA:261337
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Bor Syndrome
Branchial cyst ORPHA:107
Branchiootorenal Syndrome 1
Branchial fistula, Branchial cyst OMIM:113650
Distal 22Q11.2 Microdeletion Syndrome
Atrial septal defect, Ventricular septal defect, Branchial fistula, Intrauterine growth retardati... ORPHA:261330
Oligomeganephronia
Secundum atrial septal defect, Branchial cyst ORPHA:2260
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Increased nuchal translucency, Cystic hygroma, Atrial septal defect, Ventricular septal defect, A... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Increased nuchal translucency, Cystic hygroma, Atrial septal defect, Ventricular septal defect, A... ORPHA:352665
Treacher-Collins Syndrome
Encephalocele, Branchial fistula, Patent ductus arteriosus ORPHA:861
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
8Q24.3 Microdeletion Syndrome
Ventricular septal defect, Dysplastic aortic valve, Atrioventricular canal defect, Short neck, In... ORPHA:508488
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Atrial septal defect, Intrauterine growth retardation, Right ventricular hypertrophy, Branchial c... OMIM:620186
Craniofacial Microsomia
Tetralogy of Fallot, Ventricular septal defect, Hydrocephalus, Occipital encephalocele, Patent du... OMIM:164210
Branchiooculofacial Syndrome
Agenesis of cerebellar vermis, Short neck, Low posterior hairline, Intrauterine growth retardatio... OMIM:113620
Witteveen-Kolk Syndrome
Branchial fistula, Intrauterine growth retardation OMIM:613406
Reticulate Acropigmentation Of Kitamura
OMIM:615537

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adam10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adam10.

No publications found that use IMPC mice or data for Adam10.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Adam10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adam10tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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