Gene: Trpc5 MGI:109524

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Gene Summary

Name:
transient receptor potential cation channel, subfamily C, member 5
Synonyms:
CCE2,  TRP5,  Trrp5

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Wholemount images hemizygote Ambiguous
Adrenal gland  Wholemount images heterozygote Ambiguous
Adrenal gland  Wholemount images homozygote Ambiguous
Bone  Wholemount images hemizygote Ambiguous
Bone  Wholemount images heterozygote Ambiguous
Bone  Wholemount images homozygote Ambiguous
Cecum  Wholemount images hemizygote Ambiguous
Cecum  Wholemount images heterozygote Ambiguous
Cecum  Wholemount images homozygote Ambiguous
Chest bone  Wholemount images hemizygote Ambiguous
Chest bone  Wholemount images heterozygote Ambiguous
Chest bone  Wholemount images homozygote Ambiguous
Duodenum  Wholemount images hemizygote Ambiguous
Duodenum  Wholemount images heterozygote Ambiguous
Duodenum  Wholemount images homozygote Ambiguous
Epididymis  Wholemount images hemizygote Ambiguous
Gall bladder  Wholemount images hemizygote Ambiguous
Gall bladder  Wholemount images heterozygote Ambiguous
Gall bladder  Wholemount images homozygote Ambiguous
Harderian gland  Wholemount images hemizygote Ambiguous
Harderian gland  Wholemount images heterozygote Ambiguous
Harderian gland  Wholemount images homozygote Ambiguous
Ileum  Wholemount images hemizygote Ambiguous
Ileum  Wholemount images heterozygote Ambiguous
Ileum  Wholemount images homozygote Ambiguous
Jejunum  Wholemount images hemizygote Ambiguous
Jejunum  Wholemount images heterozygote Ambiguous
Jejunum  Wholemount images homozygote Ambiguous
Kidney  Wholemount images hemizygote Ambiguous
Kidney  Wholemount images heterozygote Ambiguous
Kidney  Wholemount images homozygote Ambiguous
Large intestine  Wholemount images hemizygote Ambiguous
Large intestine  Wholemount images heterozygote Ambiguous
Large intestine  Wholemount images homozygote Ambiguous
Liver  Wholemount images hemizygote Ambiguous
Liver  Wholemount images heterozygote Ambiguous
Liver  Wholemount images homozygote Ambiguous
Lung  Wholemount images hemizygote Ambiguous
Lung  Wholemount images heterozygote Ambiguous
Lung  Wholemount images homozygote Ambiguous
Lymph node  Wholemount images hemizygote Ambiguous
Lymph node  Wholemount images heterozygote Ambiguous
Lymph node  Wholemount images homozygote Ambiguous
Mesenteric lymph node  Wholemount images hemizygote Ambiguous
Mesenteric lymph node  Wholemount images heterozygote Ambiguous
Mesenteric lymph node  Wholemount images homozygote Ambiguous
Ovary  Wholemount images heterozygote Ambiguous
Ovary  Wholemount images homozygote Ambiguous
Oviduct  Wholemount images heterozygote Ambiguous
Oviduct  Wholemount images homozygote Ambiguous
Pancreas  Wholemount images heterozygote Ambiguous
Pancreas  Wholemount images homozygote Ambiguous
Parotid gland  Wholemount images hemizygote Ambiguous
Parotid gland  Wholemount images heterozygote Ambiguous
Parotid gland  Wholemount images homozygote Ambiguous
Pituitary gland  Wholemount images hemizygote Ambiguous
Pituitary gland  Wholemount images heterozygote Ambiguous
Pituitary gland  Wholemount images homozygote Ambiguous
Prostate gland  Wholemount images hemizygote Ambiguous
Skin  Wholemount images hemizygote Ambiguous
Skin  Wholemount images heterozygote Ambiguous
Skin  Wholemount images homozygote Ambiguous
Spleen  Wholemount images hemizygote Ambiguous
Spleen  Wholemount images heterozygote Ambiguous
Spleen  Wholemount images homozygote Ambiguous
Stomach  Wholemount images hemizygote Ambiguous
Stomach  Wholemount images heterozygote Ambiguous
Stomach  Wholemount images homozygote Ambiguous
Sublingual gland  Wholemount images hemizygote Ambiguous
Sublingual gland  Wholemount images heterozygote Ambiguous
Sublingual gland  Wholemount images homozygote Ambiguous
Submandibular gland  Wholemount images hemizygote Ambiguous
Submandibular gland  Wholemount images heterozygote Ambiguous
Submandibular gland  Wholemount images homozygote Ambiguous
Testis  Wholemount images hemizygote Ambiguous
Thymus  Wholemount images hemizygote Ambiguous
Thymus  Wholemount images heterozygote Ambiguous
Thyroid gland  Wholemount images hemizygote Ambiguous
Thyroid gland  Wholemount images heterozygote Ambiguous
Thyroid gland  Wholemount images homozygote Ambiguous
Trigeminal V nerve  Wholemount images hemizygote 0.0% (0 of 1)
Trigeminal V nerve  Wholemount images heterozygote 0.0% (0 of 2)
Trigeminal V nerve  Wholemount images homozygote 0.0% (0 of 1)
Urinary bladder  Wholemount images hemizygote Ambiguous
Urinary bladder  Wholemount images heterozygote Ambiguous
Urinary bladder  Wholemount images homozygote Ambiguous
Uterus  Wholemount images heterozygote Ambiguous
Uterus  Wholemount images homozygote Ambiguous
Vagina  Wholemount images homozygote 100% (1 of 1)
Vesicular gland  Wholemount images hemizygote Ambiguous
Aorta N/A hemizygote 0.0% (0 of 1)
Aorta N/A heterozygote 0.0% (0 of 2)
Aorta N/A homozygote 0.0% (0 of 1)
Brain N/A hemizygote Ambiguous
Brain N/A heterozygote Ambiguous
Brain N/A homozygote Ambiguous
Brainstem N/A hemizygote 0.0% (0 of 1)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brainstem N/A homozygote 0.0% (0 of 1)
Brown adipose tissue N/A hemizygote 0.0% (0 of 1)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A homozygote 0.0% (0 of 1)
Cartilage tissue N/A hemizygote Ambiguous
Cartilage tissue N/A heterozygote Ambiguous
Cartilage tissue N/A homozygote Ambiguous
Cerebellum N/A hemizygote 0.0% (0 of 1)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A homozygote 0.0% (0 of 1)
Cerebral cortex N/A hemizygote 0.0% (0 of 1)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A homozygote 0.0% (0 of 1)
Colon N/A hemizygote Ambiguous
Colon N/A heterozygote Ambiguous
Colon N/A homozygote Ambiguous
Cranium N/A hemizygote Ambiguous
Cranium N/A heterozygote Ambiguous
Cranium N/A homozygote Ambiguous
Diaphragm N/A hemizygote 0.0% (0 of 1)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Diaphragm N/A homozygote 0.0% (0 of 1)
Epididymis N/A heterozygote Not available
Epididymis N/A homozygote Not available
Esophagus N/A hemizygote 0.0% (0 of 1)
Esophagus N/A heterozygote 0.0% (0 of 2)
Esophagus N/A homozygote 0.0% (0 of 1)
Eye N/A hemizygote 0.0% (0 of 1)
Eye N/A heterozygote 0.0% (0 of 2)
Eye N/A homozygote 0.0% (0 of 1)
Gonadal fat pad N/A hemizygote 0.0% (0 of 1)
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Gonadal fat pad N/A homozygote 0.0% (0 of 1)
Heart N/A hemizygote 0.0% (0 of 1)
Heart N/A heterozygote 0.0% (0 of 2)
Heart N/A homozygote 0.0% (0 of 1)
Hindlimb N/A hemizygote 0.0% (0 of 1)
Hindlimb N/A heterozygote 0.0% (0 of 2)
Hindlimb N/A homozygote 0.0% (0 of 1)
Hippocampus N/A hemizygote 0.0% (0 of 1)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A homozygote 0.0% (0 of 1)
Hypothalamus N/A hemizygote 0.0% (0 of 1)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A homozygote 0.0% (0 of 1)
Lower urinary tract N/A hemizygote Ambiguous
Lower urinary tract N/A heterozygote Ambiguous
Lower urinary tract N/A homozygote Ambiguous
Main olfactory bulb N/A hemizygote 0.0% (0 of 1)
Main olfactory bulb N/A heterozygote 0.0% (0 of 2)
Main olfactory bulb N/A homozygote 0.0% (0 of 1)
Mammary gland N/A hemizygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A homozygote 0.0% (0 of 1)
Mesenteric adipose tissue N/A hemizygote 0.0% (0 of 1)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A homozygote 0.0% (0 of 1)
Midbrain N/A hemizygote 0.0% (0 of 1)
Midbrain N/A heterozygote 0.0% (0 of 2)
Midbrain N/A homozygote 0.0% (0 of 1)
Olfactory lobe N/A hemizygote 0.0% (0 of 1)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A homozygote 0.0% (0 of 1)
Oral epithelium N/A hemizygote 0.0% (0 of 1)
Oral epithelium N/A heterozygote 0.0% (0 of 2)
Oral epithelium N/A homozygote 0.0% (0 of 1)
Ovary N/A hemizygote Not available
Oviduct N/A hemizygote Not available
Pancreas N/A hemizygote 0.0% (0 of 1)
Parathyroid gland N/A hemizygote 0.0% (0 of 1)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A homozygote 0.0% (0 of 1)
Penis N/A hemizygote 0.0% (0 of 1)
Penis N/A heterozygote Not available
Penis N/A homozygote Not available
Peripheral nervous system N/A hemizygote 0.0% (0 of 1)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A homozygote 0.0% (0 of 1)
Peyer's patch N/A hemizygote 0.0% (0 of 1)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A homozygote 0.0% (0 of 1)
Prostate gland N/A heterozygote Not available
Prostate gland N/A homozygote Not available
Quadriceps N/A hemizygote 0.0% (0 of 1)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Quadriceps N/A homozygote 0.0% (0 of 1)
Sciatic nerve N/A hemizygote 0.0% (0 of 1)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A homozygote 0.0% (0 of 1)
Skeletal muscle N/A hemizygote 0.0% (0 of 1)
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A homozygote 0.0% (0 of 1)
Small intestine N/A hemizygote Ambiguous
Small intestine N/A heterozygote Ambiguous
Small intestine N/A homozygote Ambiguous
Spinal cord N/A hemizygote 0.0% (0 of 1)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A homozygote 0.0% (0 of 1)
Stomach pyloric region N/A hemizygote 0.0% (0 of 1)
Stomach pyloric region N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A homozygote 0.0% (0 of 1)
Striatum N/A hemizygote 0.0% (0 of 1)
Striatum N/A heterozygote 0.0% (0 of 2)
Striatum N/A homozygote 0.0% (0 of 1)
Testis N/A heterozygote Not available
Testis N/A homozygote Not available
Thalamus N/A hemizygote 0.0% (0 of 1)
Thalamus N/A heterozygote 0.0% (0 of 2)
Thalamus N/A homozygote 0.0% (0 of 1)
Thymus N/A homozygote Ambiguous
Tongue N/A hemizygote 0.0% (0 of 1)
Tongue N/A heterozygote 0.0% (0 of 2)
Tongue N/A homozygote 0.0% (0 of 1)
Trachea N/A hemizygote 0.0% (0 of 1)
Trachea N/A heterozygote 0.0% (0 of 2)
Trachea N/A homozygote 0.0% (0 of 1)
Uterus N/A hemizygote Not available
Vagina N/A hemizygote Not available
Vagina N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A hemizygote Ambiguous
Vas deferens N/A heterozygote Not available
Vas deferens N/A homozygote Not available
Vascular system N/A hemizygote 0.0% (0 of 1)
Vascular system N/A heterozygote 0.0% (0 of 2)
Vascular system N/A homozygote 0.0% (0 of 1)
Vesicular gland N/A heterozygote Not available
Vesicular gland N/A homozygote Not available
White adipose tissue N/A hemizygote 0.0% (0 of 1)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A homozygote 0.0% (0 of 1)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
N/A heterozygote Ambiguous
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote Ambiguous
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)
N/A heterozygote 0.0% (0 of 3)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
bone 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cecum 2.97% (11 of 370)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
chest bone Unavailable
colon 8.73% (11 of 126)
cranium
diaphragm 0.0%
duodenum 0.79% (1 of 126)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.0%
heart 0.34% (2 of 584)
hindlimb 0.0%
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
ileum 10.32% (13 of 126)
jejunum 3.97% (5 of 126)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
main olfactory bulb 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
oral epithelium 0.0%
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
stomach pyloric region 0.0%
striatum 0.51% (3 of 584)
sublingual gland 0.0%
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thalamus 0.0%
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
tongue 3.97% (5 of 126)
trachea 0.51% (3 of 584)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vagina 0.0%
vas deferens 3.67% (14 of 381)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.18% (6 of 507)
ear 0.2% (1 of 507)
embryo 0.2% (1 of 508)
eye 0.2% (1 of 507)
footplate 0.2% (1 of 507)
forearm 0.33% (1 of 304)
forebrain 0.2% (1 of 507)
forelimb 0.2% (1 of 507)
handplate 0.2% (1 of 507)
head 0.99% (5 of 507)
heart 0.2% (1 of 507)
hindbrain 1.18% (6 of 507)
hindlimb 0.2% (1 of 507)
liver 0.2% (1 of 502)
lower leg 0.33% (1 of 304)
lung 0.2% (1 of 502)
mandibular process 0.2% (1 of 507)
maxillary process 0.2% (1 of 507)
midbrain 0.2% (1 of 507)
oral cavity 0.2% (1 of 502)
skin 0.2% (1 of 507)
tail 0.2% (1 of 507)
tail somite group 0.2% (1 of 507)
upper arm 0.33% (1 of 304)
upper leg 0.33% (1 of 304)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Wholemount

152 Images

Embryo LacZ

LacZ images wholemount

6 Images

Human diseases caused by Trpc5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Trpc5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Severe Primary Trimethylaminuria
ORPHA:468726
Mental Retardation, Autosomal Recessive 25
OMIM:614346
Panic Disorder 1
OMIM:167870
Major Affective Disorder 1
OMIM:125480
Prolactin Deficiency, Isolated
OMIM:264110
Intellectual Developmental Disorder, X-Linked 63
OMIM:300387
Obsessive-Compulsive Disorder
OMIM:164230
Persistent Idiopathic Facial Pain
ORPHA:398147
Premature Ovarian Failure 1
OMIM:311360
Hyperprolactinemia
OMIM:615555
Premature Ovarian Failure 9
OMIM:615724
Invasive Mole
ORPHA:99925
Geniospasm 1
OMIM:190100
Familial Alzheimer-Like Prion Disease
ORPHA:280397
Endometriosis, Susceptibility To, 1
OMIM:131200
Premature Ovarian Failure 19
OMIM:619245
Adenomyosis
OMIM:600458
Premature Ovarian Failure 11
OMIM:616946
Amenorrhea-Galactorrhea Syndrome
OMIM:104600
Leydig Cell Hypoplasia, Type I
OMIM:238320
Post-Traumatic Pituitary Deficiency
ORPHA:95619
Ovarian Dysgenesis 1
OMIM:233300
Premature Ovarian Failure 14
OMIM:618014
Pituicytoma
ORPHA:251623
Premature Ovarian Failure 15
OMIM:618096
Premature Ovarian Failure 13
OMIM:617442
Premature Ovarian Failure 8
OMIM:615723
Premature Ovarian Failure 5
OMIM:611548
Functioning Gonadotropic Adenoma
ORPHA:91348
Chorea, Benign Hereditary
OMIM:118700
Pituitary Hormone Deficiency, Combined, 2
OMIM:262600
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
ORPHA:399805
Hypogonadism-Cataract Syndrome
OMIM:240950
Asherman Syndrome
ORPHA:137686
Gordon Holmes Syndrome
OMIM:212840
Premature Ovarian Failure 2A
OMIM:300511
Premature Ovarian Failure 17
OMIM:619146
Premature Ovarian Failure 6
OMIM:612310
Hypogonadotropic Hypogonadism 24 Without Anosmia
OMIM:229070
Premature Ovarian Failure 16
OMIM:618723
Non-Functioning Pituitary Adenoma
ORPHA:91349
Premature Ovarian Failure 18
OMIM:619203
Hypergonadotropic Hypogonadism-Cataract Syndrome
ORPHA:2410
Childhood-Onset Benign Chorea With Striatal Involvement
ORPHA:494541
Intellectual Developmental Disorder, X-Linked, With Panhypopituitarism
OMIM:300123
Myoclonus-Dystonia Syndrome
ORPHA:36899
Familial Hyperprolactinemia
ORPHA:397685
Dystonia 11, Myoclonic
OMIM:159900
Premature Ovarian Failure 10
OMIM:612885
Adenohypophysitis
ORPHA:95512
Male Infertility With Teratozoospermia Due To Single Gene Mutation
ORPHA:399808
Panhypophysitis
ORPHA:95513
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
ORPHA:2235
Hypothyroidism, Central, With Testicular Enlargement
OMIM:300888
Premature Ovarian Failure 7
OMIM:612964
Bonnemann-Meinecke-Reich Syndrome
ORPHA:1261
Pandas
ORPHA:66624
Ovarian Dysgenesis 3
OMIM:614324
Isolated Growth Hormone Deficiency, Type Ib
OMIM:612781
Spermatogenic Failure 28
OMIM:618086
Gangliocytoma
ORPHA:251937
Pituitary Dwarfism With Large Sella Turcica
OMIM:262710
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
ORPHA:91354
Placental Site Trophoblastic Tumor
ORPHA:99928
Leptin Receptor Deficiency
OMIM:614963
Hyperostosis Frontalis Interna
OMIM:144800
Ovarian Dysgenesis 8
OMIM:618187
Isolated Growth Hormone Deficiency, Type Ii
OMIM:173100
Hypersecretion Of Adrenal Androgens, Familial
OMIM:145295
Pituitary Adenoma 1, Multiple Types
OMIM:102200
Isolated Growth Hormone Deficiency, Type Ia
OMIM:262400
Resistance To Thyrotropin-Releasing Hormone Syndrome
ORPHA:99832
Parkinsonism With Polyneuropathy
OMIM:619279
46,Xy Sex Reversal 11
OMIM:273250
Pituitary Apoplexy
ORPHA:95613
Glucocorticoid Resistance, Generalized
OMIM:615962
Prolactin Deficiency With Obesity And Enlarged Testes
OMIM:264120
Huntington Disease-Like 2
OMIM:606438
Isolated Follicle Stimulating Hormone Deficiency
ORPHA:52901
Sheehan Syndrome
ORPHA:91355
Ane Syndrome
ORPHA:157954
Cortisone Reductase Deficiency 1
OMIM:604931
Arthrogryposis, distal, with hypopituitarism, mental retardation,and facial anomalies
OMIM:208080
Non-Acquired Panhypopituitarism
ORPHA:90695
Perrault Syndrome 6
OMIM:617565
Polycystic Ovary Syndrome 1
OMIM:184700
Oliver-Mcfarlane Syndrome
OMIM:275400
Isolated Growth Hormone Deficiency, Type V
OMIM:618160
Mehmo Syndrome
OMIM:300148
Prolactinoma
ORPHA:2965
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
OMIM:614839
Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome
ORPHA:231720
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
ORPHA:168563
Isolated Growth Hormone Deficiency, Type Iv
OMIM:618157
Premature Ovarian Failure 3
OMIM:608996
Androgen Insensitivity Syndrome
OMIM:300068
46,Xy Sex Reversal 1
OMIM:400044
Joubert Syndrome 26
OMIM:616784
Dystonia 26, Myoclonic
OMIM:616398
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
OMIM:609734
Perrault Syndrome 2
OMIM:614926
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
OMIM:614837
Early-Onset Schizophrenia
ORPHA:96369
Perrault Syndrome 4
OMIM:615300
Pituitary Dermoid And Epidermoid Cysts
ORPHA:91351
Perrault Syndrome 1
OMIM:233400
Pseudohypoparathyroidism Type 1C
ORPHA:79444
X-Linked Intellectual Disability, Van Esch Type
ORPHA:163976
Combined Pituitary Hormone Deficiencies, Genetic Forms
ORPHA:95494
Hypogonadotropic Hypogonadism 23 Without Anosmia
OMIM:228300
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
OMIM:614858
Pituitary Hormone Deficiency, Combined, 3
OMIM:221750
Meningioma
ORPHA:2495
46,Xx Gonadal Dysgenesis
ORPHA:243
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
ORPHA:90793
Precocious Puberty, Central, 1
OMIM:176400
Growth Hormone Deficiency, Isolated Partial
OMIM:615925
Gestational Choriocarcinoma
ORPHA:99926
49,Xxxyy Syndrome
ORPHA:261534
Obesity Due To Prohormone Convertase I Deficiency
ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
ORPHA:71526
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
ORPHA:226307
Hypogonadotropic Hypogonadism 25 With Anosmia
OMIM:618841
Gray Platelet Syndrome
ORPHA:721
Chromosome Xq27.3-Q28 Duplication Syndrome
OMIM:300869
49,Xyyyy Syndrome
ORPHA:99330
Leydig Cell Hypoplasia
ORPHA:755
Encephalopathy With Intracranial Calcification, Growth Hormone Deficiency, Microcephaly, And Retinal Degeneration
OMIM:225755
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
OMIM:615286
Pseudohypoparathyroidism Type 1A
ORPHA:79443
X-Linked Intellectual Disability, Cilliers Type
ORPHA:163971
Adrenocortical Carcinoma
ORPHA:1501
Frasier Syndrome
ORPHA:347
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
ORPHA:457240
Hydatidiform Mole
ORPHA:99927
Pituitary Carcinoma
ORPHA:300385
Pituitary Deficiency Due To Rathke Cleft Cysts
ORPHA:91350
Tsh-Secreting Pituitary Adenoma
ORPHA:91347
4H Leukodystrophy
ORPHA:289494
47,Xyy Syndrome
ORPHA:8
Combined Oxidative Phosphorylation Deficiency 25
OMIM:616430
Complete Androgen Insensitivity Syndrome
ORPHA:99429
Estrogen Resistance Syndrome
ORPHA:785
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
ORPHA:98754
Moyamoya Angiopathy-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome
ORPHA:280679
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
ORPHA:177904
Septooptic Dysplasia
OMIM:182230
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
ORPHA:177901
Pseudohypoparathyroidism Type 1B
ORPHA:94089
Fowler Urethral Sphincter Dysfunction Syndrome
ORPHA:2795
Central Precocious Puberty
ORPHA:759
Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities
OMIM:618922
Blepharophimosis, Ptosis, And Epicanthus Inversus
OMIM:110100
Wolfram Syndrome 2
OMIM:604928
Growth Hormone Insensitivity Syndrome With Immune Dysregulation 1, Autosomal Recessive
OMIM:245590
Myasthenic Syndrome, Congenital, 22
OMIM:616224
Moyamoya Disease 4 With Short Stature, Hypergonadotropic Hypogonadism, And Facial Dysmorphism
OMIM:300845
Prader-Willi-Like Syndrome
ORPHA:398073
Carney Complex
ORPHA:1359
African Trypanosomiasis
ORPHA:3385
Gomez-Lopez-Hernandez Syndrome
OMIM:601853
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
ORPHA:2232
Partial Androgen Insensitivity Syndrome
ORPHA:90797
46,Xy Disorder Of Sex Development Due To Isolated 17,20-Lyase Deficiency
ORPHA:90796
Myotonic Dystrophy 2
OMIM:602668
Hypotonia-Cystinuria Syndrome
OMIM:606407
X-Linked Intellectual Disability With Isolated Growth Hormone Deficiency
ORPHA:67045
Williams-Beuren Region Duplication Syndrome
OMIM:609757
Galloway-Mowat Syndrome 6
OMIM:618347
Juberg-Hayward Syndrome
OMIM:216100
46,Xy Partial Gonadal Dysgenesis
ORPHA:251510
Maternal Uniparental Disomy Of Chromosome 2
ORPHA:96179
Rhyns Syndrome
OMIM:602152
Boomerang Dysplasia
ORPHA:1263
46,Xy Sex Reversal 5
OMIM:613080
16P12.1P12.3 Triplication Syndrome
ORPHA:485405
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
OMIM:614732
Mayer-Rokitansky-Kuster-Hauser Syndrome
OMIM:277000
Temple Syndrome
ORPHA:254516
Prader-Willi Syndrome
OMIM:176270
Prader-Willi Syndrome
ORPHA:739
Alstrom Syndrome
OMIM:203800
Noonan Syndrome 12
OMIM:618624
46,Xy Sex Reversal 3
OMIM:612965
46,Xx Sex Reversal 1
OMIM:400045
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
ORPHA:572333
Pallister-Hall Syndrome
ORPHA:672
Intellectual Disability-Strabismus Syndrome
ORPHA:363528
Webb-Dattani Syndrome
OMIM:615926
Acrodysostosis 1 With Or Without Hormone Resistance
OMIM:101800
Anterior Chamber Cleavage Disorder, Cerebellar Hypoplasia, Hypothyroidism, And Tracheal Stenosis
OMIM:601427
Srd5A3-Cdg
ORPHA:324737
Glucagonoma
ORPHA:97280
Steinert Myotonic Dystrophy
ORPHA:273
Hymen, Imperforate
OMIM:237100
Tbck-Related Intellectual Disability Syndrome
ORPHA:488632
Interstitial Cystitis
ORPHA:37202
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome
ORPHA:436174
Prader-Willi Syndrome Due To Translocation
ORPHA:177907
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
ORPHA:293987
Woodhouse-Sakati Syndrome
ORPHA:3464
Fanconi Anemia, Complementation Group I
OMIM:609053
Cohen Syndrome
OMIM:216550
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
ORPHA:289548
Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia
OMIM:616007
Solitary Median Maxillary Central Incisor
OMIM:147250
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
ORPHA:168558
Fanconi Anemia, Complementation Group W
OMIM:617784
Deeah Syndrome
OMIM:619004
Ritscher-Schinzel Syndrome 1
OMIM:220210
Ppoma
ORPHA:97278
Intellectual Disability-Dysmorphism-Hypogonadism-Diabetes Mellitus Syndrome
ORPHA:3044
Hypoparathyroidism-Retardation-Dysmorphism Syndrome
OMIM:241410
Aarskog-Scott Syndrome
OMIM:305400
Grfoma
ORPHA:97261
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
OMIM:610978
Vipoma
ORPHA:97282
Wiedemann-Steiner Syndrome
ORPHA:319182
Immunodeficiency, Common Variable, 10
OMIM:615577
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
ORPHA:293978
Somatostatinoma
ORPHA:97283
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies, And Immunodeficiency
OMIM:618336
Silver-Russell Syndrome 1
OMIM:180860
Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation Syndrome
OMIM:213980
Semilobar Holoprosencephaly
ORPHA:220386
Alobar Holoprosencephaly
ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
ORPHA:93926
Lobar Holoprosencephaly
ORPHA:93924
15Q24 Microdeletion Syndrome
ORPHA:94065
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
OMIM:307200
Pseudopapilledema, Ocular Hypotelorism, Blepharophimosis, And Hand Anomalies
OMIM:264475
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
ORPHA:95699
Helsmoortel-Van Der Aa Syndrome
OMIM:615873
Gonadal Dysgenesis, Dysmorphic Facies, Retinal Dystrophy, And Myopathy
OMIM:618419
Short Stature, Oligodontia, Dysmorphic Facies, And Motor Delay
OMIM:619234
Koolen-De Vries Syndrome Due To A Point Mutation
ORPHA:363965
17Q21.31 Microdeletion Syndrome
ORPHA:363958
Acrootoocular Syndrome
ORPHA:2980
Ovarian Hyperstimulation Syndrome
ORPHA:64739
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
ORPHA:268261
Chromosome 18Q Deletion Syndrome
OMIM:601808
Acrodysostosis With Multiple Hormone Resistance
ORPHA:280651
Spondyloenchondrodysplasia
ORPHA:1855
Histiocytosis-Lymphadenopathy Plus Syndrome
OMIM:602782
45,X/46,Xy Mixed Gonadal Dysgenesis
ORPHA:1772
Turner Syndrome Due To Structural X Chromosome Anomalies
ORPHA:99413
Turner Syndrome
ORPHA:881
Mosaic Monosomy X
ORPHA:99228
Monosomy X
ORPHA:99226
Pallister-Hall Syndrome
OMIM:146510
Global Developmental Delay, Absent Or Hypoplastic Corpus Callosum, And Dysmorphic Facies
OMIM:617260
Van Esch-O'Driscoll Syndrome
OMIM:301030
Mosaic Variegated Aneuploidy Syndrome 2
OMIM:614114
Holoprosencephaly 9
OMIM:610829
Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction
OMIM:618223
Fanconi Anemia, Complementation Group F
OMIM:603467
Xq21 Microdeletion Syndrome
ORPHA:1435
Meier-Gorlin Syndrome 6
OMIM:616835
Testicular Agenesis
ORPHA:325124
Seckel Syndrome 10
OMIM:617253
Eec Syndrome
ORPHA:1896
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
ORPHA:96182
Witteveen-Kolk Syndrome
OMIM:613406
Monosomy 18Q
ORPHA:1600
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
OMIM:604292
Gabriele-De Vries Syndrome
ORPHA:506358
Shwachman-Diamond Syndrome
ORPHA:811
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
OMIM:129900
Pearson Syndrome
ORPHA:699
Charge Syndrome
OMIM:214800
Wiedemann-Rautenstrauch Syndrome
ORPHA:3455
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
ORPHA:444077
Lysinuric Protein Intolerance
ORPHA:470
Alström Syndrome
ORPHA:64
Axenfeld-Rieger Syndrome, Type 1
OMIM:180500

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trpc5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trpc5.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget (July 2018) Trpc5tm1b(KOMP)Wtsi PMC6049859

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MGI Allele Allele Type Produced
Trpc5tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trpc5tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Trpc5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Trpc5tm41118(L1L2_gt1) Targeting vectors

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