Gene Summary

Name:
CCCTC-binding factor
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

View all 195 images

View all 6 images

Human diseases caused by Ctcf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ctcf by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mental Retardation, Autosomal Dominant 21
Patent ductus arteriosus OMIM:615502
Ctcf-Related Neurodevelopmental Disorder
Patent ductus arteriosus ORPHA:363611

The table below shows human diseases predicted to be associated to Ctcf by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mental Retardation, Autosomal Dominant 21
Patent ductus arteriosus OMIM:615502
Ctcf-Related Neurodevelopmental Disorder
Patent ductus arteriosus ORPHA:363611

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Liver - lipid deposition Ctcftm1a(EUCOMM)Wtsi HET Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ctcf.

There are 9 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Liver-Specific Deletion of Mouse CTCF Leads to Hepatic Steatosis via Augmented PPARĪ³ Signaling. Cellular and molecular gastroenterology and hepatology (August 2021) Ctcftm1c(EUCOMM)Wtsi PMC8551791
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature communications (August 2020) Ctcftm1a(EUCOMM)Wtsi PMC7431862
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ctcftm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Ctcftm1a(EUCOMM)Wtsi PMC6459510
CTCF deficiency causes expansion of the sensory domain in the mouse cochlea. Biochemical and biophysical research communications (March 2019) Ctcftm1c(EUCOMM)Wtsi 30929920
CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea. Biochemical and biophysical research communications (August 2018) Ctcftm1c(EUCOMM)Wtsi 30107916
CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus. Molecules and cells (July 2018) Ctcftm1c(EUCOMM)Wtsi Ctcftm1a(EUCOMM)Wtsi PMC6078853
CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice. Experimental & molecular medicine (August 2017) Ctcftm1c(EUCOMM)Wtsi PMC5579513
CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells. The Journal of allergy and clinical immunology (May 2015) Ctcftm1c(EUCOMM)Wtsi Ctcftm1a(EUCOMM)Wtsi 25936568

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MGI Allele Allele Type Produced
Ctcftm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ctcftm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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