Gene: Itga8

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Phenotype System Allele Zyg Sex Life Stage P Value
increased total body fat amount Itga8tm1b(KOMP)Wtsi HET Early adult 4.40×10-05
increased circulating sodium level Itga8tm1b(KOMP)Wtsi HET Early adult 4.81×10-05
increased circulating calcium level Itga8tm1b(KOMP)Wtsi HET Early adult 1.27×10-06
decreased circulating glucose level Itga8tm1b(KOMP)Wtsi HET Early adult 1.76×10-05
preweaning lethality, incomplete penetrance Itga8tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased thigmotaxis Itga8tm1b(KOMP)Wtsi HET Early adult 7.08×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590)  (2/2)  Section images
Brain 2 No  (3/590) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590)  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590)  (2/2)  Section images
Hypothalamus 2 No  (2/590)  (2/2)  Section images
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590)  (2/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/590)  (2/2)  Section images
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590)  (2/2)  Section images
Stomach 2 No  (13/590)  (2/2)  Section images
Striatum 2 No  (3/590) N/A
Submandibular gland 2 No  (2/132)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (1/3) N/A
Dorsal root ganglion 1  (1/61) Image Only N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (2/3)  Wholemount images
Eye 2  (1/506) N/A
Foot 2  (1/506)  (2/3) N/A
Forebrain 2  (1/506)  (1/3) N/A
Forelimb 2  (1/506)  (2/3) N/A
Fronto-nasal process 1  (1/62) Image Only N/A
Gut 1  (1/60)  (1/1) N/A
Hand 2  (1/506)  (2/3) N/A
Head 2  (5/506)  (2/3) N/A
Heart 2  (1/506) N/A
Hindbrain 2  (6/506)  (1/3) N/A
Hindlimb 2  (1/506)  (2/3) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506)  (2/3) N/A
Maxillary process 2  (1/506)  (2/3) N/A
Midbrain 2  (1/506)  (1/3) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 2  (1/504)  (1/3) N/A
Rib pre-cartilage condensation 1  (1/58)  (1/1) N/A
Skin 2  (1/506)  (2/3) N/A
Spinal cord 1  (1/73) Image Only N/A
Tail 2  (1/506) N/A
Tail somite 2  (1/506) N/A
Umbilical artery embryonic part 1  (1/61)  (1/1) N/A
Umbilical vein embryonic part 1  (1/61)  (1/1) N/A
Vibrissa 1  (1/72)  (1/1) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Original Image
Adult LacZ: LacZ Images Section
20 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Combined SHIRPA and Dysmorphology
6 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Itga8tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Itga8tm39262(L1L2_Bact_P) Targeting vectors
Itga8tm39262(L1L2_gt1) Targeting vectors
Itga8tm39262(L1L2_Pgk_P) Targeting vectors
Itga8tm39262(L1L2_Pgk_PM) Targeting vectors
Itga8tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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