Atf3 | activating transcription factor 3

GeneMGI:109384Synonyms: LRG-21

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Vision/eye Behavior/neurological

16 No significant impact

6 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

abnormal retina morphology1 supporting datasetAtf3tm2b(EUCOMM)WtsihomozygoteEarly adult9.45x10-6 
decreased locomotor activity1 supporting datasetAtf3tm2b(EUCOMM)WtsihomozygoteEarly adult9.9x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/1)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Atf3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Atf3tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Atf3tm2b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Atf3tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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