Gene: Pitx2

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Name
paired-like homeodomain transcription factor 2
MGI ID
MGI:109340
Synonyms
Otlx2 Brx1b Brx1a Brx1 solurshin Ptx2 Munc30 Pitx2c Pitx2b Pitx2a Rieg
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Pitx2tm1b(EUCOMM)Wtsi HET Early adult 5.97×10-08
abnormal tooth morphology Pitx2tm1b(EUCOMM)Wtsi HET Early adult 1.07×10-08
enlarged heart Pitx2tm1b(EUCOMM)Wtsi HET Early adult 0.00
preweaning lethality, complete penetrance Pitx2tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
small testis Pitx2tm1b(EUCOMM)Wtsi HET Early adult 0.00
corneal opacity Pitx2tm1b(EUCOMM)Wtsi HET Early adult 1.53×10-12
irregularly shaped pupil Pitx2tm1b(EUCOMM)Wtsi HET Early adult 7.64×10-06
prenatal lethality Pitx2tm1b(EUCOMM)Wtsi HOM   E18.5 0.00
abnormal optic disk morphology Pitx2tm1b(EUCOMM)Wtsi HET Early adult 9.47×10-16
increased exploration in new environment Pitx2tm1b(EUCOMM)Wtsi HET Early adult 7.65×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Esophagus 2 No  (7/407)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583) N/A
Large intestine 2 No  (10/583) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/583) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (2/2)  Wholemount images
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583) N/A
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Echo: M-Mode Images
28 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
9 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pitx2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Pitx2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells