Gene: Nxn

Name
nucleoredoxin
MGI ID
MGI:109331
Synonyms
l11Jus13
Viability
Homozygous - Lethal Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased body length Nxntm1b(EUCOMM)Wtsi HET postnatal 4.54×10-05
abnormal head shape Nxnem1(IMPC)Bay HOM embryonic day 18.5 0.00
prolonged PQ interval Nxnem1(IMPC)J HET postnatal 4.79×10-05
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00
decreased body length Nxnem1(IMPC)J HET postnatal 2.20×10-05
facial cleft Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
decreased lean body mass Nxntm1b(EUCOMM)Wtsi HET postnatal 1.72×10-07
decreased cardiac muscle contractility Nxntm1a(EUCOMM)Wtsi HET postnatal 3.87×10-05
small adrenal glands Nxntm1b(EUCOMM)Wtsi HET postnatal 0.00
abnormal head size Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
facial cleft Nxnem1(IMPC)Bay HOM embryonic day 18.5 0.00
increased grip strength Nxntm1a(EUCOMM)Wtsi HET postnatal 1.13×10-05
abnormal cranium morphology Nxntm1b(EUCOMM)Wtsi HET postnatal 2.38×10-05
increased or absent threshold for auditory brainstem response Nxntm1b(EUCOMM)Wtsi HET postnatal 5.09×10-05
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
preweaning lethality, complete penetrance Nxnem1(IMPC)Mbp HOM n/a 0.00
facial cleft Nxnem1(IMPC)J HOM embryonic day 18.5 0.00
abnormal bone structure Nxntm1b(EUCOMM)Wtsi HET postnatal 1.88×10-05
cleft palate Nxntm1b(EUCOMM)Wtsi HOM embryonic day 15.5 0.00
abnormal retinal blood vessel morphology Nxnem1(IMPC)Bay HET postnatal 1.90×10-05
abnormal facial morphology Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
anophthalmia Nxntm1a(EUCOMM)Wtsi HET postnatal 0.00
abnormal snout morphology Nxntm1b(EUCOMM)Wtsi HET postnatal 6.65×10-06
preweaning lethality, complete penetrance Nxntm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased bone mineral content Nxnem1(IMPC)J HET postnatal 9.99×10-05
abnormal bone structure Nxnem1(IMPC)J HET postnatal 5.25×10-05
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM embryonic day 15.5 0.00
preweaning lethality, complete penetrance Nxnem1(IMPC)J HOM n/a 0.00
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM embryonic day 15.5 0.00
preweaning lethality, complete penetrance Nxnem1(IMPC)Bay HOM n/a 0.00
abnormal head shape Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
short tibia Nxntm1b(EUCOMM)Wtsi HET postnatal 7.57×10-07
cleft palate Nxntm1b(EUCOMM)Wtsi HOM embryonic day 18.5 0.00
abnormal head size Nxnem1(IMPC)Bay HOM embryonic day 18.5 0.00
decreased lean body mass Nxnem1(IMPC)Bay HET postnatal 8.18×10-05
abnormal facial morphology Nxnem1(IMPC)J HOM embryonic day 18.5 0.00
abnormal embryo size Nxnem1(IMPC)J HOM embryonic day 18.5 0.00
cleft palate Nxnem1(IMPC)J HOM embryonic day 18.5 0.00
decreased bone mineral content Nxntm1b(EUCOMM)Wtsi HET postnatal 3.84×10-05
abnormal eyelid morphology Nxntm1b(EUCOMM)Wtsi HET postnatal 1.94×10-05
preweaning lethality, incomplete penetrance Nxntm1a(EUCOMM)Wtsi HOM n/a 0.00
abnormal digit morphology Nxntm1b(EUCOMM)Wtsi HET postnatal 7.98×10-07
abnormal embryo size Nxnem1(IMPC)Bay HOM embryonic day 18.5 0.00
abnormal facial morphology Nxnem1(IMPC)Bay HOM embryonic day 18.5 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 16 No  (2/584)  (13/16)  Wholemount images
Aorta 16 No  (13/16)  Wholemount images
Blood 2 No N/A
Blood vessel 2 No  (2/2) N/A
Bone 12 No  (2/12)  Wholemount images
Bone marrow 2 No N/A
Brain 16 No  (16/16)  Wholemount images  Section images
Brainstem 16 No  (10/16)  Wholemount images  Section images
Brown adipose tissue 14 No  Wholemount images
Cartilage tissue 16 No  (10/16)  Wholemount images
Cecum 8 No  (12/383)  (6/8)  Wholemount images
Cerebellum 16 No  (9/16)  Wholemount images  Section images
Cerebral cortex 16 No  (8/16)  Wholemount images
Chest bone 6 No  (4/6)  Wholemount images
Colon 6 No  (12/127)  (4/6) N/A
Cranium 6 No N/A
Diaphragm 6 No  (4/6)  Wholemount images
Duodenum 4 No  (2/127)  (4/4)  Wholemount images
Epididymis 8 No  (18/134)  (1/8)  Wholemount images
Esophagus 14 No  (7/415)  (12/14)  Wholemount images
Eye 16 No  (12/16)  Wholemount images  Section images
Gall bladder 12 No  (10/12)  Wholemount images
Gonadal fat pad 4 No N/A
Harderian gland 6 No  (4/6)  Wholemount images
Heart 16 No  (6/16)  Wholemount images  Section images
Hindlimb 6 No  (4/6) N/A
Hippocampus 16 No  (8/16)  Wholemount images
Hypothalamus 16 No  (8/16)  Wholemount images
Ileum 4 No  (14/127)  (4/4)  Wholemount images
Jejunum 4 No  (6/127)  (4/4)  Wholemount images
Kidney 16 No  (18/584)  (16/16)  Wholemount images
Large intestine 16 No  (10/584)  (14/16)  Wholemount images
Liver 16 No  (2/16)  Wholemount images
Lower urinary tract 16 No  (11/16)  Wholemount images
Lung 16 No  (15/16)  Wholemount images  Section images
Lymph node 16 No  (6/16)  Wholemount images
Main olfactory bulb 6 No  (4/6)  Wholemount images
Mammary gland 16 No  (7/16)  Wholemount images  Section images
Mesenteric adipose tissue 4 No  (4/4)  Wholemount images
Mesenteric lymph node 8 No  (2/8)  Wholemount images
Midbrain 6 No  (6/6) N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 16 No  (10/16)  Wholemount images
Oral epithelium 10 No  (4/10)  Wholemount images
Ovary 16 No  (1/584)  (7/16)  Wholemount images  Section images
Oviduct 16 No  (7/16)  Wholemount images
Pancreas 16 No  (5/584)  (1/16)  Wholemount images
Parathyroid gland 12 No  (2/12)  Wholemount images
Parotid gland 6 No  (4/6)  Wholemount images
Penis 6 No  (2/6)  Wholemount images
Peripheral nervous system 16 No  (13/16)  Wholemount images
Peyer's patch 2 No  (2/2) N/A
Peyer's patch 14 No  (4/14)  Wholemount images
Pituitary gland 16 No  (12/16)  Wholemount images
Prostate gland 16 No  (12/584)  (6/16)  Wholemount images
Quadriceps 4 No  (4/4)  Wholemount images
Sciatic nerve 6 No  (4/6)  Wholemount images
Skeletal muscle 14 No  (12/14)  Wholemount images
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 16 No  (14/16)  Wholemount images  Section images
Small intestine 16 No  (9/584)  (14/16)  Wholemount images
Spinal cord 16 No  (14/16)  Wholemount images
Spleen 16 No  (2/584)  (6/16)  Wholemount images  Section images
Stomach 16 No  (12/584)  (15/16)  Wholemount images
Stomach pyloric region 6 No N/A
Striatum 16 No  (8/16)  Wholemount images
Sublingual gland 6 No  (4/6)  Wholemount images
Submandibular gland 8 No  (2/132)  (4/8)  Wholemount images
Testis 16 No  (2/584)  (8/16)  Wholemount images
Thalamus 6 No  (2/6) N/A
Thymus 16 No  (7/16)  Wholemount images
Thyroid gland 16 No  (15/584)  (4/16)  Wholemount images
Tongue 6 No  (5/127)  (4/6)  Wholemount images
Trachea 16 No  (14/16)  Wholemount images
Trigeminal V nerve 8 No  (6/8)  Wholemount images
Urinary bladder 10 No  (8/10)  Wholemount images
Uterus 16 No  (8/16)  Wholemount images  Section images
Vagina 6 No  (2/6)  Wholemount images
Vas deferens 8 No  (15/388)  Wholemount images
Vascular system 14 No  (12/14)  Wholemount images
Vesicular gland 8 No  (2/8)  Wholemount images
White adipose tissue 16 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 6  (1/47)  (9/9) N/A
Axial skeleton 8  (1/51)  (11/11) N/A
Brain 22  (6/485)  (27/29) N/A
Central nervous system ganglion 8  (1/51)  (11/11) N/A
Cranium 4  (1/46)  (4/4) N/A
Dorsal root ganglion 7  (1/47)  (10/10) N/A
Ear 22  (1/485)  (25/29) N/A
Embryo 22  (1/485)  (27/29)  Wholemount images
Outer ear 6  (1/47)  (9/9) N/A
Eye 22  (1/485)  (27/29)  Wholemount images
Femur pre-cartilage condensation 4  (1/46)  (4/4) N/A
Foot 22  (1/485)  (27/29) N/A
Forearm 14  (1/282)  (17/17) N/A
Forebrain 22  (1/485)  (27/29) N/A
Forelimb 22  (1/485)  (27/29)  Wholemount images
Fronto-nasal process 7  (1/48)  (9/10) N/A
Gut 8  (1/50)  (10/11) N/A
Hand 22  (1/485)  (27/29) N/A
Head 22  (5/485)  (27/29)  Wholemount images
Head mesenchyme 6  (1/47)  (9/9) N/A
Heart 22  (1/485)  (17/29)  Wholemount images
Heart ventricle 6  (1/47)  (9/9) N/A
Hindbrain 22  (6/485)  (27/29) N/A
Hindlimb 22  (1/485)  (27/29)  Wholemount images
Humerus pre-cartilage condensation 4  (1/46)  (4/4) N/A
Inner ear 4  (1/46)  (4/4) N/A
Intestine 6  (1/47)  (9/9) N/A
Liver 22  (1/485)  (16/29)  Wholemount images
Lower leg 14  (1/282)  (17/17) N/A
Lung 22  (1/485)  (15/29) N/A
Mandibular process 22  (1/485)  (25/29)  Wholemount images
Maxillary process 22  (1/485)  (25/29)  Wholemount images
Meckel's cartilage 2  (5/5) N/A
Mesonephros of female 4  (1/46)  (3/4) N/A
Mesonephros of male 4  (1/46)  (3/4) N/A
Metanephros 4  (1/46)  (4/5) N/A
Midbrain 22  (1/485)  (27/29) N/A
Nasal septum 6  (1/47)  (9/9) N/A
Nose 10  (1/51)  (13/13) N/A
Notochord 7  (1/47)  (10/10) N/A
Oral cavity 22  (1/485)  (16/29) N/A
Outflow tract 6  (1/47)  (9/9) N/A
Pancreas 4  (1/46)  (4/4) N/A
Pericardium 6  (1/46)  (9/9) N/A
Pharynx 4  (1/46)  (4/4) N/A
1  (7/25) N/A
Radius-ulna pre-cartilage condensation 4  (1/46)  (4/4) N/A
Rib pre-cartilage condensation 6  (1/46)  (8/8) N/A
Skeleton 8  (1/51)  (11/11) N/A
Skin 22  (1/485)  (25/29) N/A
Spinal cord 9  (1/50)  (12/12) N/A
Stomach 4  (1/46)  (4/4) N/A
Tail 22  (1/485)  (27/29)  Wholemount images
Tail somite 22  (1/485)  (27/29) N/A
Thoracic vertebral cartilage condensation 4  (1/46)  (5/5) N/A
Tongue 4  (1/46)  (5/5) N/A
Trachea 6  (1/50)  (6/6) N/A
Trunk mesenchyme 6  (1/47)  (9/9) N/A
Umbilical artery embryonic part 4  (1/47)  (4/4) N/A
Umbilical vein embryonic part 4  (1/47)  (4/4) N/A
Upper arm 14  (1/282)  (17/17) N/A
Upper leg 14  (1/282)  (17/17) N/A
Urinary system 6  (1/50)  (6/6) N/A
Vibrissa 7  (1/47)  (10/10) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
276 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Dorso Ventral
152 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
59 Images
X-ray: XRay Images Lateral Orientation
113 Images
Embryo LacZ: LacZ images section
3 Images
Embryo LacZ: LacZ images wholemount
87 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Sleep Wake: Wake state (bmp file)
21 Images
Electroretinography 2: Rod and cone PDF
3 Images

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nxntm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells, Tissue
Nxntm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Nxnem1(IMPC)Bay Exon Deletion Mice, Tissue
Nxnem1(IMPC)Mbp Null reporter Mice, Tissue
Nxnem1(IMPC)J Indel Mice
Nxntm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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