Fadd | Fas associated via death domain

GeneMGI:109324Synonyms: Mort1/FADD

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Reproductive system Adipose tissue Embryo Growth/size/body region Nervous system Mortality/aging

13 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:41Adult tissues
29Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsFaddtm1e.1(KOMP)WtsihomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetFaddtm1e.1(KOMP)WtsiheterozygoteEarly adult7.18x10-5 
decreased lean body mass1 supporting datasetFaddtm1e.1(KOMP)WtsiheterozygoteEarly adult9.71x10-12 
abnormal neural tube closure1 supporting datasetFaddtm1e.1(KOMP)WtsihomozygoteE9.5N/A * 
abnormal uterus morphology1 supporting datasetFaddtm1e.1(KOMP)WtsiheterozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetFaddtm1e.1(KOMP)WtsihomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Faddtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Faddtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
mouse
Faddtm1e.1(KOMP)WtsiPromoter excision from Targeted, non-conditional allelemouse

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