Genes Phenotypes

Gene: Mmp15

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Name
matrix metallopeptidase 15
MGI ID
MGI:109320
Synonyms
Membrane type 2-MMP MT2-MMP
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (208) All data table (499)
Expression & images (51) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
athymia Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased circulating alanine transaminase level Mmp15tm1b(KOMP)Wtsi HOM postnatal 8.64×10-05
absent lymph nodes Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
enlarged spleen Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal thyroid gland morphology Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal trachea morphology Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal pancreas morphology Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
abnormal skin coloration Mmp15tm1b(KOMP)Wtsi HOM postnatal 1.76×10-06
abnormal esophagus morphology Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00
anophthalmia Mmp15tm1b(KOMP)Wtsi HOM postnatal 0.00

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (1/2)  Wholemount images
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (1)
cardiovascular system (2)
Heart expression
Vascular System expression
MA:0000072
MA:0002718
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
nervous system (4)
Peripheral Nervous System expression
Striatum expression
Brain expression
Olfactory Lobe expression
MA:0000218
MA:0000891
MA:0000168
MA:0002413
postnatal mouse (9)
Heart expression
Vascular System expression
MA:0000072
MA:0002718
reproductive system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
trunk (6)
Heart expression
Vascular System expression
MA:0000072
MA:0002718
urinary system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Wholemount
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Mmp15tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Mmp15tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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