Mapkapk2 | MAP kinase-activated protein kinase 2
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Vision/eye Hematopoietic system Skeleton
14 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased large unstained cell number | 2 supporting datasets | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.41x10-6 | ||
| abnormal clavicle morphology | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.25x10-5 | ||
| increased circulating glucose level | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.08x10-6 | ||
| abnormal joint morphology | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.08x10-5 | ||
| abnormal optic disk morphology | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.03x10-6 | ||
| increased eosinophil cell number | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.14x10-5 | ||
| increased leukocyte cell number | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.2x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Mapkapk2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.61x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (3/3) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 75% (3/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/3) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (4/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/3) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (4/4) | 1.67% (7/419) |
Human diseases caused by Mapkapk2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mapkapk2.
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| Mapkapk2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mapkapk2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mapkapk2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |