Gene: Mapkapk2

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Name
MAP kinase-activated protein kinase 2
MGI ID
MGI:109298
Synonyms
MAPKAP kinase 2 Rps6kc1 MK2
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal optic disk morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 2.68×10-05
abnormal bone structure Mapkapk2tm1b(EUCOMM)Hmgu HOM   Early adult 3.73×10-05
increased circulating cholesterol level Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 6.63×10-05
abnormal joint morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 1.11×10-05
increased circulating iron level Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 9.43×10-07
increased circulating glucose level Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 4.38×10-05
abnormal clavicle morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 3.33×10-05
increased circulating HDL cholesterol level Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 4.85×10-05
increased circulating calcium level Mapkapk2tm1b(EUCOMM)Hmgu HOM Early adult 9.83×10-05

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (4/583)  (3/4)  Wholemount images
Aorta 4 No  (1/583)  (4/4)  Wholemount images
Bone 4 No N/A
Brain 4 No  (4/583)  (3/4)  Wholemount images
Brainstem 4 No  (2/583) N/A
Brown adipose tissue 4 No  (4/4)  Wholemount images
Cartilage tissue 4 No  (1/583) N/A
Cerebellum 4 No  (3/583) N/A
Cerebral cortex 4 No  (2/583) N/A
Esophagus 4 No  (7/407)  (4/4)  Wholemount images
Eye 4 No N/A
Gall bladder 4 No  (4/4)  Wholemount images
Heart 4 No  (2/583)  (4/4)  Wholemount images
Hippocampus 4 No  (3/583) N/A
Hypothalamus 4 No  (2/583) N/A
Kidney 4 No  (21/583)  (4/4)  Wholemount images
Large intestine 4 No  (10/583)  (3/4)  Wholemount images
Liver 4 No N/A
Lower urinary tract 4 No  (1/583)  (4/4)  Wholemount images
Lung 4 No  (2/583)  (4/4)  Wholemount images
Lymph node 4 No  (1/583) N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (2/583) N/A
Oral epithelium 4 No  (1/4) N/A
Ovary 4 No  (1/583)  (2/4)  Wholemount images
Oviduct 4 No  (2/4)  Wholemount images
Pancreas 4 No  (5/583) N/A
Parathyroid gland 4 No  (1/563)  (3/4)  Wholemount images
Peripheral nervous system 4 No  (2/583) N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/583) N/A
Prostate gland 4 No  (12/583) N/A
Skeletal muscle 4 No N/A
Skin 4 No  (1/583)  Wholemount images
Small intestine 4 No  (9/583)  (4/4) N/A
Spinal cord 4 No  (3/583) N/A
Spleen 4 No  (3/583) N/A
Stomach 4 No  (13/583)  (4/4)  Wholemount images
Striatum 4 No  (3/583) N/A
Testis 4 No  (6/583)  (2/4)  Wholemount images
Thymus 4 No  (1/583) N/A
Thyroid gland 4 No  (17/583) N/A
Trachea 4 No  (3/583)  (1/4) N/A
Uterus 4 No  (2/4)  Wholemount images
Vascular system 4 No N/A
White adipose tissue 4 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Echo: M-Mode Images
32 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
15 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Mapkapk2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Mapkapk2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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