Psen2 | presenilin 2

GeneMGI:109284Synonyms: Ad4h, PS2, +2 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal thymus morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal retina morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adult7.52x10-5 
abnormal digit morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adult4.99x10-8 
abnormal heart morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged thymus1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
hydrocephaly1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased mean corpuscular hemoglobin1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adult7.49x10-5 
abnormal brain morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal seminal vesicle morphology1 supporting datasetPsen2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Psen2em1(IMPC)CcpczExon Deletionmouse
Psen2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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