Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tripartite motif-containing 28
Synonyms:
KAP-1,  MommeD9,  KRIP-1,  Tif1b

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Trim28 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trim28 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nephroblastoma
ORPHA:654

The table below shows human diseases predicted to be associated to Trim28 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
46,Xy Sex Reversal 9
Sex reversal, Ambiguous genitalia, Fused labia minora, Gonadal dysgenesis OMIM:616067
46,Xy Sex Reversal 8
Cryptorchidism, Sex reversal, Male pseudohermaphroditism, Ambiguous genitalia OMIM:614279
46,Xy Sex Reversal 10
Micropenis, Gonadoblastoma, Sex reversal, Ambiguous genitalia, Dysgerminoma, Decreased testicular... OMIM:616425
46,Xy Ovotesticular Disorder Of Sex Development
Abnormality of the clitoris, Abnormality of the female genitalia, Perineal hypospadias, Ovotestis... ORPHA:325345
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Spina bifida, Encephalocele, Hydrocephalus ORPHA:1931
Acalvaria
Holoprosencephaly, Spina bifida, Cleft palate, Hydrocephalus ORPHA:945
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ectopic anus, Anencephaly, Spina bifida, Cleft palate ORPHA:2476
46,Xy Sex Reversal 1
Primary amenorrhea, Abnormality of female external genitalia, Gonadoblastoma, Male pseudohermaphr... OMIM:400044
46,Xy Sex Reversal 2
Sex reversal OMIM:300018
46,Xx Sex Reversal 3
Sex reversal OMIM:300833
46,Xy Sex Reversal 7
Abnormality of the epididymis, Hypoplasia of the uterus, Primary amenorrhea, Gonadal dysgenesis, ... OMIM:233420
Schisis Association
Anencephaly, Tracheoesophageal fistula, Anal atresia, Spina bifida, Cleft palate, Encephalocele ORPHA:63862
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Fryns Microphthalmia Syndrome
Neural tube defect, Bilateral cleft lip and palate OMIM:600776
46,Xy Sex Reversal 3
Hypoplasia of the uterus, Penoscrotal hypospadias, Sex reversal, Ambiguous genitalia, Exaggerated... OMIM:612965
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Acropectorovertebral Dysplasia
Spina bifida, Cleft palate, High, narrow palate ORPHA:957
Caudal Duplication
Intestinal duplication, Spina bifida, Myelomeningocele ORPHA:1756
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Anal atresia, Sirenomelia, Spinal dysraphism ORPHA:63260
46,Xy Sex Reversal 6
Chordee, Hypospadias, Gonadoblastoma, Sex reversal, Dysgerminoma, Clitoral hypertrophy OMIM:613762
Sirenomelia
Spina bifida, Tracheoesophageal fistula, Anal atresia, Sirenomelia ORPHA:3169
Isolated Klippel-Feil Syndrome
Ectopic anus, Spina bifida, Cleft palate, Anal atresia ORPHA:2345
46,Xx Sex Reversal 2
Perineal hypospadias, Small scrotum, Ovotestis, Hypoplasia of the vagina, Azoospermia, Micropenis... OMIM:278850
Blepharocheilodontic Syndrome 1
Neural tube defect, Anal atresia OMIM:119580
Chiari Malformation Type Ii
Myelomeningocele, Spina bifida, Cervical myelopathy, Hydrocephalus OMIM:207950
46,Xy Sex Reversal 5
Sex reversal OMIM:613080
Anophthalmia Plus Syndrome
Spina bifida, Bilateral cleft lip and palate, Cleft palate ORPHA:1104
46,Xy Partial Gonadal Dysgenesis
Primary amenorrhea, Cryptorchidism, Abnormal labia morphology, Male infertility, Abnormal sex det... ORPHA:251510
Amish Lethal Microcephaly
Cleft soft palate, Spina bifida ORPHA:99742
Camptodactyly Syndrome, Guadalajara Type 1
High palate, Spina bifida ORPHA:1327
46,Xx Sex Reversal 1
Ovotestis, Azoospermia, True hermaphroditism, Sex reversal, Bicornuate uterus, Hypospadias, Clito... OMIM:400045
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Cervical spina bifida OMIM:600122
Czeizel-Losonci Syndrome
High palate, Myelomeningocele, Tracheoesophageal fistula, Spina bifida, Hydrocephalus, Spina bifi... ORPHA:2437
Alg3-Cdg
Neural tube defect, High palate, Abnormal uvula morphology, Macroglossia ORPHA:79321
Waardenburg Syndrome Type 1
Spina bifida, Meningocele, Cleft palate, Aganglionic megacolon ORPHA:894
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
46,Xy Disorder Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Decreased fertility in females, Primary amenorrhea, Hypoplasia of the vagina, Polycystic ovaries,... ORPHA:90796
Iniencephaly
Myelomeningocele, Anencephaly, Anal atresia, Spinal dysraphism, Spina bifida, Hydrocephalus, Holo... ORPHA:63259
Cerebrocostomandibular Syndrome
Myelomeningocele, Hydranencephaly, Spina bifida, Short hard palate, Glossoptosis, Meningocele, Cl... ORPHA:1393
Pelvis-Shoulder Dysplasia
Hydranencephaly, Microglossia, Spina bifida, Hydrocephalus, Cleft palate ORPHA:2839
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Lumbar Syndrome
Ectopic anus, Spina bifida, Myelomeningocele, Anal atresia ORPHA:83628
Vacterl With Hydrocephalus
Tracheoesophageal fistula, Esophageal atresia, Anal atresia, Spina bifida, Hydrocephalus, Aqueduc... ORPHA:3412
Trisomy 20P
Umbilical hernia, Ectopic anus, Spina bifida ORPHA:261318
Fanconi Anemia, Complementation Group C
Short stature, Prolonged G2 phase of cell cycle, Intrauterine growth retardation OMIM:227645
Posterior Meningocele
Occipital meningocele, Lipomyelomeningocele, Neural tube defect, Hydrocephalus, Meningocele ORPHA:268810
Limb Body Wall Complex
Short umbilical cord, Myelomeningocele, Anencephaly, Spina bifida, Abnormal intestine morphology,... ORPHA:2369
Cloacal Exstrophy
Myelomeningocele, Intestinal malrotation, Intestinal duplication, Anal atresia, Spina bifida ORPHA:93929
Fanconi Anemia, Complementation Group E
Short stature, Prolonged G2 phase of cell cycle OMIM:600901
Trisomy 18
Anencephaly, Anal atresia, Esophageal atresia, Spina bifida, Holoprosencephaly, Narrow palate, Cl... ORPHA:3380
Fanconi Anemia, Complementation Group A
Short stature, Prolonged G2 phase of cell cycle OMIM:227650
Mosaic Trisomy 9
High palate, Spina bifida, Intestinal malrotation, Cleft palate ORPHA:99776
Fanconi Anemia, Complementation Group D2
Short stature, Prolonged G2 phase of cell cycle, Hydrocephalus OMIM:227646
Nail-Patella Syndrome
Spina bifida, Cleft palate OMIM:161200
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Neu-Laxova Syndrome
Submucous cleft hard palate, Spina bifida, Bifid uvula, Cleft palate ORPHA:2671
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida, Duodenal atresia ORPHA:2092
Basal Cell Nevus Syndrome
Hamartomatous stomach polyps, Spina bifida, Cleft palate, Hydrocephalus OMIM:109400
Fibular Hemimelia
Spina bifida ORPHA:93323
Neu-Laxova Syndrome 1
Short umbilical cord, Hydranencephaly, Spina bifida, Small placenta, Cleft palate, Stillbirth OMIM:256520
Pagod Syndrome
Spina bifida, Meningocele, Encephalocele ORPHA:991
Hallermann-Streiff Syndrome
High palate, Spina bifida, Narrow palate, High, narrow palate OMIM:234100
Jacobsen Syndrome
Ectopic anus, Intestinal malrotation, Spina bifida, Abnormality of the anus, Pyloric stenosis, Du... ORPHA:2308
Fanconi Anemia
High palate, Tracheoesophageal fistula, Aganglionic megacolon, Aplasia/Hypoplasia of the uvula, A... ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Spina bifida, Meckel diverticulum OMIM:274000
22Q11.2 Deletion Syndrome
Occipital myelomeningocele, Intestinal malrotation, Aganglionic megacolon, Anal atresia, Spina bi... ORPHA:567
Aicardi Syndrome
Hiatus hernia, Spina bifida, Cleft palate OMIM:304050
Neurofibromatosis, Type I
Spina bifida, Aqueductal stenosis, Hydrocephalus OMIM:162200
Campomelic Dysplasia
High palate, Spinal dysraphism, Submucous cleft hard palate, Spina bifida, Hydrocephalus, Cleft p... OMIM:114290
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Vater/Vacterl Association
Occipital encephalocele, Tracheoesophageal fistula, Anal atresia, Patent urachus, Esophageal atre... OMIM:192350
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida, Bifid uvula OMIM:619480
Koolen-De Vries Syndrome Due To A Point Mutation
Spina bifida, Hydrocephalus ORPHA:363965
17Q21.31 Microdeletion Syndrome
Spina bifida, Hydrocephalus ORPHA:363958
Exstrophy-Epispadias Complex
Anal atresia, Spina bifida, Anal stenosis, Hydrocephalus ORPHA:322
Alobar Holoprosencephaly
Neural tube defect, Short stature, Growth delay, Hydrocephalus ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Short stature, Growth delay, Hydrocephalus ORPHA:93926
Semilobar Holoprosencephaly
Neural tube defect, Short stature, Growth delay, Hydrocephalus ORPHA:220386
Lobar Holoprosencephaly
Neural tube defect, Short stature, Growth delay, Hydrocephalus ORPHA:93924
Split Cord Malformation
Myelomeningocele, Cervical spina bifida, Lipomyelomeningocele, Hydrocephalus, Meningocele ORPHA:573278
Schinzel-Giedion Syndrome
Neural tube defect, Umbilical hernia ORPHA:798
Nephroblastoma
ORPHA:654

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trim28

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim28.

No publications found that use IMPC mice or data for Trim28.

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MGI Allele Allele Type Produced
Trim28tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Trim28tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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