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Gene: Trim28 MGI:109274

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tripartite motif-containing 28
Synonyms:
KAP-1,  MommeD9,  KRIP-1,  Tif1b

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Trim28 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trim28 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nephroblastoma
ORPHA:654

The table below shows human diseases predicted to be associated to Trim28 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
46,Xy Sex Reversal 9
Sex reversal, Gonadal dysgenesis, Fused labia minora, Ambiguous genitalia OMIM:616067
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
46,Xy Sex Reversal 8
Sex reversal, Cryptorchidism, Male pseudohermaphroditism, Ambiguous genitalia OMIM:614279
46,Xy Ovotesticular Difference Of Sex Development
Bifid scrotum, Ambiguous genitalia, True hermaphroditism, Abnormal labia morphology, Fused labia ... ORPHA:325345
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Acalvaria
Cleft palate, Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
46,Xy Sex Reversal 1
Abnormality of male external genitalia, Hypergonadotropic hypogonadism, Abnormality of the menstr... OMIM:400044
46,Xy Sex Reversal 10
Bifid scrotum, Small scrotum, Hypospadias, Ovotestis, Testicular dysgenesis, Perineal hypospadias... OMIM:616425
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Cleft palate, Ectopic anus, Anencephaly, Spina bifida ORPHA:2476
46,Xy Sex Reversal 2
Sex reversal OMIM:300018
46,Xx Sex Reversal 3
Sex reversal OMIM:300833
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Schisis Association
Encephalocele, Spina bifida, Anencephaly, Tracheoesophageal fistula, Cleft palate, Anal atresia ORPHA:63862
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Fryns Microphthalmia Syndrome
Neural tube defect, Bilateral cleft lip and palate OMIM:600776
Thoraco-Abdominal Enteric Duplication
Meningocele, Intestinal malrotation, Duodenal stenosis ORPHA:1759
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
46,Xy Sex Reversal 6
Hypospadias, Sex reversal, Gonadal dysgenesis, Chordee, Dysgerminoma, Gonadoblastoma, Clitoral hy... OMIM:613762
46,Xy Sex Reversal 3
Penoscrotal hypospadias, Hypoplasia of the uterus, Sex reversal, Gonadal dysgenesis, Exaggerated ... OMIM:612965
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Subependymal Nodular Heterotopia
Occipital encephalocele, Myelomeningocele, Meningocele, Nasofrontal encephalocele ORPHA:101030
46,Xy Sex Reversal 7
Streak ovary, Hypoplasia of the fallopian tube, Primary amenorrhea, Hypoplasia of the uterus, Sex... OMIM:233420
Caudal Duplication
Myelomeningocele, Intestinal duplication, Spina bifida ORPHA:1756
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Acropectorovertebral Dysplasia
High, narrow palate, Cleft palate, Spina bifida ORPHA:957
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism, Anal atresia ORPHA:63260
Isolated Klippel-Feil Syndrome
Cleft palate, Ectopic anus, Anal atresia, Spina bifida ORPHA:2345
Wildervanck Syndrome
Meningocele ORPHA:3456
46,Xx Sex Reversal 2
Bifid scrotum, Hypoplasia of the vagina, Small scrotum, True hermaphroditism, Ovotestis, Perineal... OMIM:278850
Sirenomelia
Anal atresia, Tracheoesophageal fistula, Spina bifida, Sirenomelia ORPHA:3169
Diaphanospondylodysostosis
Myelomeningocele, Cleft palate ORPHA:66637
Meckel Syndrome, Type 2
Encephalocele, Intestinal malrotation, Meningocele, Anencephaly, Cleft palate OMIM:603194
Humero-Radial Synostosis
Meningocele ORPHA:3265
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida OMIM:207950
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Cleft palate, Spinal dysraphism, Holopros... ORPHA:1908
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Cleft palate OMIM:611134
46,Xy Sex Reversal 5
Sex reversal OMIM:613080
Blepharocheilodontic Syndrome 1
Neural tube defect, Anal atresia OMIM:119580
Anophthalmia Plus Syndrome
Cleft palate, Spina bifida, Bilateral cleft lip and palate ORPHA:1104
Enlarged Parietal Foramina
Occipital encephalocele, Myelomeningocele, Cleft palate ORPHA:60015
Camptodactyly Syndrome, Guadalajara Type 1
High palate, Spina bifida ORPHA:1327
46,Xy Partial Gonadal Dysgenesis
Hypoplasia of the vagina, Hypoplasia of penis, Vanishing testis, Micropenis, Ovarian gonadoblasto... ORPHA:251510
Czeizel-Losonci Syndrome
Spina bifida, Myelomeningocele, Hydrocephalus, Tracheoesophageal fistula, High palate, Spina bifi... ORPHA:2437
Triploidy
Intestinal malrotation, Hydrocephalus, Meningocele, Cleft palate, Macroglossia, Holoprosencephaly ORPHA:3376
Waardenburg Syndrome Type 1
Cleft palate, Meningocele, Aganglionic megacolon, Spina bifida ORPHA:894
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele, Bilateral cleft lip and palate ORPHA:2003
Alg3-Cdg
Macroglossia, Neural tube defect, Abnormal uvula morphology, High palate ORPHA:79321
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Autosomal Recessive Spondylocostal Dysostosis
Umbilical hernia, Meningocele, Spina bifida occulta, Cleft palate ORPHA:2311
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Glossoptosis, Meningocele ORPHA:2031
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Joubert Syndrome 14
Encephalocele, Hydrocephalus, Meningocele, Cleft palate OMIM:614424
Amish Lethal Microcephaly
Cleft soft palate, Spina bifida ORPHA:99742
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Rectal abscess OMIM:600145
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Cerebrocostomandibular Syndrome
Spina bifida, Myelomeningocele, Meningocele, Cleft palate, Glossoptosis, Hydranencephaly, Short h... ORPHA:1393
Iniencephaly
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Hol... ORPHA:63259
Pelvis-Shoulder Dysplasia
Spina bifida, Hydrocephalus, Cleft palate, Hydranencephaly, Microglossia ORPHA:2839
Lateral Meningocele Syndrome
Umbilical hernia, Meningocele, High palate, High, narrow palate ORPHA:2789
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele, Median cleft palate ORPHA:1827
Lumbar Syndrome
Anal atresia, Myelomeningocele, Ectopic anus, Spina bifida ORPHA:83628
Lateral Meningocele Syndrome
Hydrocephalus, Meningocele, Cleft palate, High palate, Umbilical hernia OMIM:130720
Neu-Laxova Syndrome 2
Cleft palate, High palate, Spina bifida OMIM:616038
Chromosome 17P13.1 Deletion Syndrome
Spina bifida, High, narrow palate, Hydrocephalus, High palate, Umbilical hernia OMIM:613776
Vacterl With Hydrocephalus
Spina bifida, Aqueductal stenosis, Esophageal atresia, Hydrocephalus, Tracheoesophageal fistula, ... ORPHA:3412
Limb Body Wall Complex
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Cleft palate, Abnormal... ORPHA:2369
Curry-Jones Syndrome
Anal stenosis, Intestinal pseudo-obstruction, Intestinal malrotation, Lipomyelomeningocele, Occip... OMIM:601707
Cloacal Exstrophy
Intestinal malrotation, Spina bifida, Myelomeningocele, Intestinal duplication, Anal atresia ORPHA:93929
Trisomy 20P
Umbilical hernia, Ectopic anus, Spina bifida ORPHA:261318
Fanconi Anemia, Complementation Group C
Intrauterine growth retardation, Prolonged G2 phase of cell cycle, Short stature OMIM:227645
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle, Short stature OMIM:600901
Trisomy 18
Spina bifida, Esophageal atresia, Anencephaly, Cleft palate, Narrow palate, Holoprosencephaly, An... ORPHA:3380
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle, Short stature OMIM:227650
Mosaic Trisomy 9
Cleft palate, High palate, Intestinal malrotation, Spina bifida ORPHA:99776
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Fanconi Anemia, Complementation Group D2
Hydrocephalus, Prolonged G2 phase of cell cycle, Short stature OMIM:227646
Nail-Patella Syndrome
Cleft palate, Spina bifida OMIM:161200
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Hamartoma of tongue, Hydrocephalus, Anencephaly, Cleft palate, Occipital meningocele OMIM:616546
Lathosterolosis
Meningocele, High palate ORPHA:46059
Phocomelia, Schinzel Type
High, narrow palate, Meningocele, Tracheoesophageal fistula, Cleft palate, Anal atresia ORPHA:2879
Neu-Laxova Syndrome
Cleft palate, Submucous cleft hard palate, Bifid uvula, Spina bifida ORPHA:2671
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida, Duodenal atresia ORPHA:2092
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Basal Cell Nevus Syndrome 1
Cleft palate, Hydrocephalus, Hamartomatous stomach polyps, Spina bifida OMIM:109400
Orofaciodigital Syndrome Vi
Hamartoma of tongue, Cleft palate, Lobulated tongue, High palate, Occipital meningocele, Tongue n... OMIM:277170
Hallermann-Streiff Syndrome
High, narrow palate, Narrow palate, High palate, Spina bifida OMIM:234100
Fibular Hemimelia
Spina bifida ORPHA:93323
Pagod Syndrome
Encephalocele, Meningocele, Spina bifida ORPHA:991
Holoprosencephaly 7
Bilateral cleft palate, Median cleft lip and palate, Alobar holoprosencephaly, Hydrocephalus, Cle... OMIM:610828
Neu-Laxova Syndrome 1
Spina bifida, Cleft palate, Stillbirth, Neonatal death, Small placenta, Short umbilical cord, Hyd... OMIM:256520
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Jacobsen Syndrome
Intestinal malrotation, Spina bifida, Pyloric stenosis, Abnormality of the anus, Ectopic anus, Du... ORPHA:2308
Fanconi Anemia
Aganglionic megacolon, Spina bifida, Aplasia/Hypoplasia of the uvula, Hydrocephalus, Tracheoesoph... ORPHA:84
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
22Q11.2 Deletion Syndrome
Aganglionic megacolon, Intestinal malrotation, Spina bifida, Hydrocephalus, Meningocele, Cleft pa... ORPHA:567
Aicardi Syndrome
Cleft palate, Spina bifida, Hiatus hernia OMIM:304050
Vater/Vacterl Association
Occipital encephalocele, Spina bifida, Esophageal atresia, Tracheoesophageal fistula, Patent urac... OMIM:192350
Campomelic Dysplasia
Spina bifida, Hydrocephalus, Submucous cleft hard palate, Cleft palate, Spinal dysraphism, High p... OMIM:114290
Split Cord Malformation
Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydrocephalus ORPHA:573278
Thrombocytopenia-Absent Radius Syndrome
Cleft palate, Meckel diverticulum, Spina bifida OMIM:274000
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Bifid uvula, Spina bifida OMIM:619480
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Arima Syndrome
Occipital meningocele, Esophageal varix OMIM:243910
Knobloch Syndrome 1
Occipital meningocele, Occipital encephalocele, Spina bifida occulta, Pyloric stenosis OMIM:267750
Marfan Syndrome
High, narrow palate, Meningocele, Cleft palate ORPHA:558
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Rubinstein-Taybi Syndrome 1
Spina bifida, High, narrow palate, Cleft palate, Narrow palate, High palate, Spina bifida occulta OMIM:180849
Otopalatodigital Syndrome, Type Ii
Spina bifida, Hydrocephalus, Cleft palate, Stillbirth, Umbilical hernia OMIM:304120
Exstrophy-Epispadias Complex
Anal stenosis, Hydrocephalus, Anal atresia, Spina bifida ORPHA:322
Semilobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:220386
Alobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93926
Lobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93924
Schinzel-Giedion Syndrome
Umbilical hernia, Neural tube defect ORPHA:798
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele, High palate, Narrow palate OMIM:276820
Nephroblastoma
ORPHA:654

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trim28

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim28.

No publications found that use IMPC mice or data for Trim28.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trim28tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Trim28tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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