Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tripartite motif-containing 28
Synonyms:
KAP-1,  MommeD9,  KRIP-1,  Tif1b

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Trim28 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trim28 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nephroblastoma
ORPHA:654

The table below shows human diseases predicted to be associated to Trim28 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
46,Xy Sex Reversal 9
Gonadal dysgenesis, Fused labia minora, Ambiguous genitalia, Sex reversal OMIM:616067
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
46,Xy Sex Reversal 8
Ambiguous genitalia, Cryptorchidism, Sex reversal, Male pseudohermaphroditism OMIM:614279
46,Xy Ovotesticular Difference Of Sex Development
Epispadias, Abnormal labia morphology, Abnormality of the female genitalia, Hyperpigmented genita... ORPHA:325345
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
46,Xy Sex Reversal 1
Gonadal dysgenesis, Abnormal female external genitalia morphology, Abnormal male external genital... OMIM:400044
Acalvaria
Hydrocephalus, Cleft palate, Holoprosencephaly, Spina bifida ORPHA:945
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
46,Xy Sex Reversal 10
Gonadal dysgenesis, Ovotestis, Hypospadias, Perineal hypospadias, Bifid scrotum, Decreased testic... OMIM:616425
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ectopic anus, Cleft palate, Anencephaly, Spina bifida ORPHA:2476
46,Xy Sex Reversal 2
Sex reversal OMIM:300018
46,Xx Sex Reversal 3
Sex reversal OMIM:300833
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Schisis Association
Anencephaly, Encephalocele, Anal atresia, Spina bifida, Tracheoesophageal fistula, Cleft palate ORPHA:63862
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
46,Xy Sex Reversal 6
Gonadal dysgenesis, Clitoral hypertrophy, Hypospadias, Chordee, Gonadoblastoma, Dysgerminoma, Sex... OMIM:613762
Neural Tube Defects, Susceptibility To
Hydrocephalus, Myelomeningocele, Anencephaly, Spina bifida occulta OMIM:182940
Thoraco-Abdominal Enteric Duplication
Intestinal malrotation, Duodenal stenosis, Meningocele ORPHA:1759
46,Xy Sex Reversal 3
Gonadal dysgenesis, Clitoral hypertrophy, Penoscrotal hypospadias, Exaggerated rugosity of the la... OMIM:612965
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
46,Xy Sex Reversal 7
Gonadal dysgenesis, male, Abnormal epididymis morphology, Gonadoblastoma, Hypoplasia of the fallo... OMIM:233420
Subependymal Nodular Heterotopia
Occipital encephalocele, Nasofrontal encephalocele, Myelomeningocele, Meningocele ORPHA:101030
Caudal Duplication
Intestinal duplication, Myelomeningocele, Spina bifida ORPHA:1756
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Acropectorovertebral Dysplasia
High, narrow palate, Cleft palate, Spina bifida ORPHA:957
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Anal atresia, Spinal dysraphism, Cervical spina bifida ORPHA:63260
Fryns Microphthalmia Syndrome
Bilateral cleft palate, Neural tube defect OMIM:600776
Isolated Klippel-Feil Syndrome
Ectopic anus, Cleft palate, Anal atresia, Spina bifida ORPHA:2345
Sirenomelia
Tracheoesophageal fistula, Sirenomelia, Anal atresia, Spina bifida ORPHA:3169
Diaphanospondylodysostosis
Cleft palate, Myelomeningocele ORPHA:66637
Meckel Syndrome, Type 2
Anencephaly, Encephalocele, Meningocele, Intestinal malrotation, Cleft palate OMIM:603194
Wildervanck Syndrome
Meningocele ORPHA:3456
Chiari Malformation Type Ii
Hydrocephalus, Cervical myelopathy, Myelomeningocele, Spina bifida OMIM:207950
Humero-Radial Synostosis
Meningocele ORPHA:3265
Muscle-Eye-Brain Disease
Hydrocephalus, Holoprosencephaly, Meningocele ORPHA:588
Aminopterin/Methotrexate Embryofetopathy
Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Cleft palate, Holoprosencephaly, Spinal d... ORPHA:1908
Meckel Syndrome, Type 4
Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Cleft palate OMIM:611134
Blepharocheilodontic Syndrome 1
Neural tube defect, Anal atresia OMIM:119580
Anophthalmia Plus Syndrome
Bilateral cleft palate, Cleft palate, Spina bifida ORPHA:1104
46,Xx Sex Reversal 2
Hypoplasia of the uterus, Ovotestis, Azoospermia, Infertility, Bifid scrotum, True hermaphroditis... OMIM:278850
Intellectual Developmental Disorder, Autosomal Dominant 72
Spina bifida OMIM:620439
46,Xy Partial Gonadal Dysgenesis
Abnormal labia morphology, Testicular gonadoblastoma, Gonadal dysgenesis, Clitoral hypertrophy, A... ORPHA:251510
Camptodactyly Syndrome, Guadalajara Type 1
High palate, Spina bifida ORPHA:1327
Enlarged Parietal Foramina
Occipital encephalocele, Cleft palate, Myelomeningocele ORPHA:60015
46,Xx Sex Reversal 1
Clitoral hypertrophy, Ovotestis, Hypospadias, Azoospermia, Bicornuate uterus, True hermaphroditis... OMIM:400045
Triploidy
Meningocele, Hydrocephalus, Intestinal malrotation, Cleft palate, Holoprosencephaly, Macroglossia ORPHA:3376
Czeizel-Losonci Syndrome
Spina bifida occulta, Hydrocephalus, High palate, Tracheoesophageal fistula, Myelomeningocele, Sp... ORPHA:2437
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Bilateral cleft palate, Meningocele ORPHA:2003
Waardenburg Syndrome Type 1
Aganglionic megacolon, Cleft palate, Spina bifida, Meningocele ORPHA:894
Alg3-Cdg
High palate, Neural tube defect, Abnormal uvula morphology, Macroglossia ORPHA:79321
Fliedner-Zweier Syndrome
Anal atresia, High palate, Tracheoesophageal fistula, Meningocele OMIM:620511
Autosomal Recessive Spondylocostal Dysostosis
Meningocele, Cleft palate, Spina bifida occulta, Umbilical hernia ORPHA:2311
Isolated Posterior Meningocele
Neural tube defect, Meningocele, Hydrocephalus, Lipomyelomeningocele, Occipital meningocele ORPHA:268810
Amish Lethal Microcephaly
Cleft soft palate, Spina bifida ORPHA:99742
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Glossoptosis, Meningocele ORPHA:2031
Joubert Syndrome 14
Hydrocephalus, Cleft palate, Encephalocele, Meningocele OMIM:614424
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Cerebrocostomandibular Syndrome
Hydranencephaly, Meningocele, Short hard palate, Glossoptosis, Myelomeningocele, Spina bifida, Cl... ORPHA:1393
Iniencephaly
Anencephaly, Encephalocele, Hydrocephalus, Myelomeningocele, Spina bifida, Anal atresia, Holopros... ORPHA:63259
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida, Cleft palate, Microglossia ORPHA:2839
Sacral Defect With Anterior Meningocele
Myeloschisis, Meningocele, Hydrocephalus, Rectal abscess, Dermal sinus tract, Myelomeningocele OMIM:600145
Lateral Meningocele Syndrome
Meningocele, High, narrow palate, High palate, Umbilical hernia ORPHA:2789
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Acromelic Frontonasal Dysplasia
Median cleft palate, Encephalocele, Meningocele ORPHA:1827
Lumbar Syndrome
Anal atresia, Ectopic anus, Myelomeningocele, Spina bifida ORPHA:83628
Lateral Meningocele Syndrome
Meningocele, Hydrocephalus, High palate, Cleft palate, Umbilical hernia OMIM:130720
Neu-Laxova Syndrome 2
Cleft palate, High palate, Spina bifida OMIM:616038
Chromosome 17P13.1 Deletion Syndrome
High, narrow palate, Hydrocephalus, High palate, Spina bifida, Umbilical hernia OMIM:613776
Cloacal Exstrophy
Intestinal duplication, Anal atresia, Myelomeningocele, Intestinal malrotation, Spina bifida ORPHA:93929
Vacterl With Hydrocephalus
Aqueductal stenosis, Esophageal atresia, Hydrocephalus, Tracheoesophageal fistula, Spina bifida, ... ORPHA:3412
Limb Body Wall Complex
Short umbilical cord, Anencephaly, Encephalocele, Spina bifida occulta, Hydrocephalus, Abnormal i... ORPHA:2369
Trisomy 20P
Ectopic anus, Spina bifida, Umbilical hernia ORPHA:261318
Curry-Jones Syndrome
Anal stenosis, Intestinal pseudo-obstruction, Lipomyelomeningocele, Intestinal malrotation, Occip... OMIM:601707
Fanconi Anemia, Complementation Group C
Intrauterine growth retardation, Prolonged G2 phase of cell cycle, Short stature OMIM:227645
Fanconi Anemia, Complementation Group E
Short stature, Prolonged G2 phase of cell cycle OMIM:600901
Trisomy 18
Narrow palate, Anencephaly, Esophageal atresia, Anal atresia, Spina bifida, Cleft palate, Holopro... ORPHA:3380
Fanconi Anemia, Complementation Group A
Short stature, Prolonged G2 phase of cell cycle OMIM:227650
Mosaic Trisomy 9
Intestinal malrotation, Cleft palate, High palate, Spina bifida ORPHA:99776
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Fanconi Anemia, Complementation Group D2
Hydrocephalus, Prolonged G2 phase of cell cycle, Short stature OMIM:227646
Lathosterolosis
High palate, Meningocele ORPHA:46059
Nail-Patella Syndrome
Cleft palate, Spina bifida OMIM:161200
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Anencephaly, Hydrocephalus, Cleft palate, Occipital meningocele, Hamartoma of tongue OMIM:616546
Neu-Laxova Syndrome
Submucous cleft hard palate, Bifid uvula, Cleft palate, Spina bifida ORPHA:2671
Phocomelia, Schinzel Type
High, narrow palate, Meningocele, Anal atresia, Tracheoesophageal fistula, Cleft palate ORPHA:2879
Focal Dermal Hypoplasia
Duodenal atresia, Spina bifida, Umbilical hernia ORPHA:2092
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Basal Cell Nevus Syndrome 1
Hydrocephalus, Hamartomatous stomach polyps, Cleft palate, Spina bifida OMIM:109400
Hallermann-Streiff Syndrome
Narrow palate, High, narrow palate, High palate, Spina bifida OMIM:234100
Orofaciodigital Syndrome Vi
Tongue nodules, High palate, Occipital meningocele, Lobulated tongue, Cleft palate, Hamartoma of ... OMIM:277170
Fibular Hemimelia
Spina bifida ORPHA:93323
Pagod Syndrome
Spina bifida, Encephalocele, Meningocele ORPHA:991
Holoprosencephaly 7
Semilobar holoprosencephaly, Alobar holoprosencephaly, Hydrocephalus, Bilateral cleft palate, Uni... OMIM:610828
Neu-Laxova Syndrome 1
Short umbilical cord, Stillbirth, Small placenta, Hydranencephaly, Spina bifida, Neonatal death, ... OMIM:256520
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Fanconi Anemia
Aganglionic megacolon, Aplasia/Hypoplasia of the uvula, Hydrocephalus, Meckel diverticulum, High ... ORPHA:84
Jacobsen Syndrome
Ectopic anus, Spina bifida, Intestinal malrotation, Pyloric stenosis, Abnormality of the anus, Du... ORPHA:2308
Vater/Vacterl Association
Occipital encephalocele, Esophageal atresia, Tracheoesophageal fistula, Spina bifida, Anal atresi... OMIM:192350
Aicardi Syndrome
Cleft palate, Hiatus hernia, Spina bifida OMIM:304050
Neurofibromatosis, Type I
Hydrocephalus, Aqueductal stenosis, Spina bifida OMIM:162200
22Q11.2 Deletion Syndrome
Aganglionic megacolon, Meningocele, Hydrocephalus, Anal atresia, Spina bifida, Intestinal malrota... ORPHA:567
Campomelic Dysplasia
Hydrocephalus, High palate, Spina bifida, Cleft palate, Spinal dysraphism, Submucous cleft hard p... OMIM:114290
Knobloch Syndrome 1
Pyloric stenosis, Occipital encephalocele, Occipital meningocele, Spina bifida occulta OMIM:267750
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Bifid uvula, Spina bifida OMIM:619480
Thrombocytopenia-Absent Radius Syndrome
Meckel diverticulum, Cleft palate, Spina bifida OMIM:274000
Arima Syndrome
Esophageal varix, Occipital meningocele OMIM:243910
Cutis Laxa, Autosomal Recessive, Type Ib
Intussusception, Neonatal death, High palate, Spina bifida OMIM:614437
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Holoprosencephaly 9
Alobar holoprosencephaly, Hydrocephalus, Bilateral cleft palate, Short hard palate, Occipital men... OMIM:610829
Rubinstein-Taybi Syndrome 1
Narrow palate, High, narrow palate, Spina bifida occulta, High palate, Spina bifida, Cleft palate OMIM:180849
Marfan Syndrome
High, narrow palate, Cleft palate, Meningocele ORPHA:558
Otopalatodigital Syndrome, Type Ii
Stillbirth, Hydrocephalus, Spina bifida, Cleft palate, Umbilical hernia OMIM:304120
Exstrophy-Epispadias Complex
Hydrocephalus, Anal stenosis, Anal atresia, Spina bifida ORPHA:322
Femoral-Facial Syndrome
Cleft palate, Encephalocele, Spina bifida OMIM:134780
Semilobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Short stature, Growth delay ORPHA:220386
Alobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Short stature, Growth delay ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Neural tube defect, Short stature, Growth delay ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Short stature, Growth delay ORPHA:93924
Schinzel-Giedion Syndrome
Neural tube defect, Umbilical hernia ORPHA:798
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Narrow palate, Occipital meningocele, High palate OMIM:276820
Nephroblastoma
ORPHA:654

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trim28

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim28.

No publications found that use IMPC mice or data for Trim28.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trim28tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Trim28tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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