Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

cholinergic receptor, muscarinic 5
muscarinic acetylcholine receptor 5,  M5R

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chrm5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chrm5 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Paragangliomas 6
Hypertension, Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Familial Cylindromatosis
Telangiectasia of the skin ORPHA:211
Moyamoya Disease 1
Telangiectasia, Inflammatory arteriopathy OMIM:252350
Capillary Malformation-Arteriovenous Malformation 2
Telangiectasia OMIM:618196
Paragangliomas 3
Adrenal pheochromocytoma, Extraadrenal pheochromocytoma, Palpitations, Tachycardia, Chemodectoma,... OMIM:605373
Paragangliomas 1
Adrenal pheochromocytoma, Extraadrenal pheochromocytoma, Glomus tympanicum paraganglioma, Palpita... OMIM:168000
Telangiectasia, Hereditary Benign
Diffuse telangiectasia OMIM:187260
Pure Autonomic Failure
Abnormality of circulating catecholamine level, Syncope, Orthostatic hypotension ORPHA:441
Hereditary Central Diabetes Insipidus
Vomiting, Diarrhea, Polydipsia ORPHA:30925
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Telangiectasia, Hereditary Hemorrhagic, Type 5
Telangiectasia, Portal hypertension, Spontaneous, recurrent epistaxis OMIM:615506
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Familial Cold Urticaria
Hyperhidrosis, Polydipsia, Dehydration ORPHA:47045
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Central Diabetes Insipidus
Diarrhea, Dehydration, Polydipsia ORPHA:178029
Achalasia, Familial Esophageal
Xerostomia, Achalasia OMIM:200400
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Intestinal Botulism
Xerostomia, Dysphagia, Diarrhea ORPHA:178481
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Vomiting, Hypertonic dehydration, Constipation, Polydipsia OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Vomiting, Hypertonic dehydration, Constipation, Polydipsia OMIM:304800
Ochoa Syndrome
Bowel incontinence, Constipation, Polydipsia ORPHA:2704
Helix Syndrome
Polydipsia, Xerostomia, Hyperparathyroidism, Hypohidrosis, Anhidrosis OMIM:617671
Diabetes Insipidus, Neurohypophyseal, X-Linked
Polydipsia OMIM:304900
Familial Hyperaldosteronism Type I
Dexamethasone-suppressible primary hyperaldosteronism, Polydipsia, Nausea ORPHA:403
Iatrogenic Botulism
Xerostomia, Dysphagia, Constipation ORPHA:254509
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Von Hippel-Lindau Disease
Adrenal pheochromocytoma, Pancreatic endocrine tumor, Myocarditis, Hypertension, Palpitations, Ca... ORPHA:892
Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Polydipsia OMIM:613677
Pediatric-Onset Graves Disease
Increased circulating T4 level, Polydipsia, Polyphagia, Thyrotoxicosis with diffuse goiter, Oligo... ORPHA:525731
Familial Hyperaldosteronism Type Iii
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Nausea ORPHA:251274
Brain-Lung-Thyroid Syndrome
Hypoparathyroidism, Abnormal drinking behavior, Congenital hypothyroidism, Abnormal eating behavi... ORPHA:209905
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Sjogren Syndrome
Xerostomia OMIM:270150
Nephrogenic Diabetes Insipidus
Hypernatremic dehydration, Constipation, Polydipsia, Polyhydramnios ORPHA:223
Vomiting, Hypothyroidism, Dehydration, Polydipsia ORPHA:213
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Nausea ORPHA:231580
Increased circulating prolactin concentration, Polydipsia, Nausea, Decreased circulating cortisol... ORPHA:95513
East Syndrome
Salt craving, Hyperaldosteronism, Polydipsia ORPHA:199343
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Hyperaldosteronism, Polydipsia, Nausea ORPHA:369929
Pituitary Dermoid And Epidermoid Cysts
Anterior hypopituitarism, Polydipsia, Panhypopituitarism, Increased circulating prolactin concent... ORPHA:91351
Apparent Mineralocorticoid Excess
Decreased circulating aldosterone level, Polydipsia ORPHA:320
Nephronophthisis 4
Polydipsia OMIM:606966
Whipple Disease
Polydipsia, Gastrointestinal hemorrhage, Hypothyroidism, Pedal edema, Diarrhea ORPHA:3452
Renal Hypoplasia
Dehydration, Polydipsia ORPHA:93101
Septo-Optic Dysplasia Spectrum
Hypohidrosis, Constipation, Polydipsia ORPHA:3157
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Nephronophthisis 3
Polydipsia OMIM:604387
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Salt craving, Hyperaldosteronism, Polydipsia OMIM:612780
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Hyperparathyroidism, Neonatal Severe
Primary hyperparathyroidism, Constipation, Polydipsia OMIM:239200
Aplasia Of Lacrimal And Salivary Glands
Xerostomia OMIM:180920
Infantile Nephropathic Cystinosis
Vomiting, Polydipsia, Abnormality of thyroid physiology, Dehydration, Constipation ORPHA:411629
Nephronophthisis 1
Polydipsia OMIM:256100
Gitelman Syndrome
Vomiting, Salt craving, Constipation, Polydipsia OMIM:263800
Dehydration, Polydipsia ORPHA:2260
Nephronophthisis 11
Polydipsia OMIM:613550
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Abnormality of endocrine pancreas physiology, Hypothyroidism, Abnormality of exocrine pancreas ph... ORPHA:93111
Distal Renal Tubular Acidosis
Vomiting, Polydipsia, Diarrhea, Dehydration, Constipation ORPHA:18
Erdheim-Chester Disease
Hyperhidrosis, Joint swelling, Polydipsia, Pleural effusion ORPHA:35687
Cystinosis, Nephropathic
Dysphagia, Polydipsia, Primary hypothyroidism, Hypohidrosis, Oral-pharyngeal dysphagia, Exocrine ... OMIM:219800
Toxic Epidermal Necrolysis
Dysphagia, Gastrointestinal hemorrhage, Pancreatitis, Polydipsia ORPHA:537
Hyperparathyroidism-Jaw Tumor Syndrome
Dysphagia, Polydipsia, Pancreatitis, Primary hyperparathyroidism, Constipation ORPHA:99880
Gitelman Syndrome
Pericardial effusion, Primary hyperaldosteronism, Polydipsia, Constipation, Salt craving, Hyperhi... ORPHA:358
Parathyroid Carcinoma
Dysphagia, Polydipsia, Pancreatitis, Primary hyperparathyroidism, Constipation ORPHA:143
Rabson-Mendenhall Syndrome
Hypothyroidism, Polydipsia ORPHA:769
Wolfram Syndrome
Gastrointestinal hemorrhage, Constipation, Polydipsia ORPHA:3463
Juvenile Nephropathic Cystinosis
Vomiting, Hypothyroidism, Dehydration, Polydipsia ORPHA:411634
Bartter Syndrome, Type 2, Antenatal
Polydipsia, Vomiting, Polyhydramnios, Hyperaldosteronism, Diarrhea, Dehydration, Constipation OMIM:241200
Senior-Boichis Syndrome
Ascites, Polydipsia ORPHA:84081
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Central hypothyroidism, Polydipsia, Polyphagia, Gonadotropin deficiency, Hypohidrosis, Adrenocort... ORPHA:293987
Proximal Renal Tubular Acidosis
Vomiting, Diarrhea, Dehydration, Polydipsia ORPHA:47159
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Oligohydramnios, Polydipsia, Ascites ORPHA:731


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chrm5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chrm5.

No publications found that use IMPC mice or data for Chrm5.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Chrm5tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Chrm5tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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