Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

cholinergic receptor, muscarinic 5
muscarinic acetylcholine receptor 5,  M5R

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chrm5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chrm5 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Paragangliomas 6
Elevated circulating catecholamine level, Hypertension, Paraganglioma OMIM:618464
Familial Cylindromatosis
Telangiectasia of the skin ORPHA:211
Moyamoya Disease 1
Telangiectasia, Inflammatory arteriopathy OMIM:252350
Paragangliomas 3
Glomus jugular tumor, Hypertension associated with pheochromocytoma, Elevated circulating catecho... OMIM:605373
Telangiectasia, Hereditary Benign
Diffuse telangiectasia OMIM:187260
Paragangliomas 1
Glomus jugular tumor, Hypertension associated with pheochromocytoma, Elevated circulating catecho... OMIM:168000
Capillary Malformation-Arteriovenous Malformation 2
Telangiectasia OMIM:618196
Hereditary Central Diabetes Insipidus
Vomiting, Diarrhea, Polydipsia ORPHA:30925
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Pure Autonomic Failure
Orthostatic hypotension, Syncope, Abnormality of circulating catecholamine level ORPHA:441
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Telangiectasia, Hereditary Hemorrhagic, Type 5
Spontaneous, recurrent epistaxis, Portal hypertension, Telangiectasia OMIM:615506
Familial Cold Urticaria
Hyperhidrosis, Polydipsia, Dehydration ORPHA:47045
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Central Diabetes Insipidus
Diarrhea, Polydipsia, Dehydration ORPHA:178029
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Vomiting, Constipation, Polydipsia, Hypertonic dehydration OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Vomiting, Constipation, Polydipsia, Hypertonic dehydration OMIM:304800
Ochoa Syndrome
Bowel incontinence, Constipation, Polydipsia ORPHA:2704
Intestinal Botulism
Xerostomia, Diarrhea, Dysphagia ORPHA:178481
Helix Syndrome
Hypohidrosis, Anhidrosis, Hyperparathyroidism, Xerostomia, Polydipsia OMIM:617671
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Familial Hyperaldosteronism Type I
Dexamethasone-suppressible primary hyperaldosteronism, Nausea, Polydipsia ORPHA:403
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Pediatric-Onset Graves Disease
Hyperhidrosis, Hyperactivity, Diarrhea, Increased circulating T4 concentration, Thyrotoxicosis wi... ORPHA:525731
Iatrogenic Botulism
Constipation, Xerostomia, Dysphagia ORPHA:254509
Familial Hyperaldosteronism Type Iii
Glucocortocoid-insensitive primary hyperaldosteronism, Dexamethasone-suppressible primary hyperal... ORPHA:251274
Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Polydipsia OMIM:613677
Erythermalgia, Primary
Xerostomia, Hyperhidrosis, Diarrhea, Constipation OMIM:133020
Brain-Lung-Thyroid Syndrome
Hyperactivity, Compensated hypothyroidism, Hypoparathyroidism, Abnormal eating behavior, Abnormal... ORPHA:209905
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 9
Polyphagia, Polydipsia OMIM:615986
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Elevated circulating catecholamine level, Hypertension, Arrhythmia, A... ORPHA:892
Xerostomia, Constipation, Diarrhea, Dysphagia ORPHA:1267
Nephrogenic Diabetes Insipidus
Polyhydramnios, Constipation, Polydipsia, Hypernatremic dehydration ORPHA:223
Hypothyroidism, Vomiting, Polydipsia, Dehydration ORPHA:213
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Nausea, Polydipsia ORPHA:231580
Increased circulating prolactin concentration, Gonadotropin deficiency, Decreased circulating cor... ORPHA:95513
Sjogren Syndrome
Xerostomia OMIM:270150
Foodborne Botulism
Xerostomia, Constipation, Diarrhea, Dysphagia ORPHA:228371
East Syndrome
Salt craving, Hyperaldosteronism, Polydipsia ORPHA:199343
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Hyperaldosteronism, Dexamethasone-suppressible primary hyperaldosteronism, Nausea, Polydipsia ORPHA:369929
Pituitary Dermoid And Epidermoid Cysts
Increased circulating prolactin concentration, Anterior hypopituitarism, Hyperpituitarism, Panhyp... ORPHA:91351
Nephronophthisis 4
Polydipsia OMIM:606966
Septo-Optic Dysplasia Spectrum
Hypohidrosis, Constipation, Polydipsia ORPHA:3157
Whipple Disease
Hypothyroidism, Pedal edema, Diarrhea, Gastrointestinal hemorrhage, Polydipsia ORPHA:3452
Apparent Mineralocorticoid Excess
Decreased circulating aldosterone level, Polydipsia ORPHA:320
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Renal Hypoplasia
Polydipsia, Dehydration ORPHA:93101
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Hyperparathyroidism, Neonatal Severe
Primary hyperparathyroidism, Constipation, Polydipsia OMIM:239200
Nephronophthisis 3
Polydipsia OMIM:604387
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Salt craving, Hyperaldosteronism, Polydipsia OMIM:612780
Nephronophthisis 1
Polydipsia OMIM:256100
Infantile Nephropathic Cystinosis
Vomiting, Abnormality of thyroid physiology, Constipation, Dehydration, Polydipsia ORPHA:411629
Gitelman Syndrome
Salt craving, Vomiting, Constipation, Polydipsia OMIM:263800
Aplasia Of Lacrimal And Salivary Glands
Xerostomia OMIM:180920
Nephronophthisis 11
Polydipsia OMIM:613550
Senior-Boichis Syndrome
Agitation, Ascites, Attention deficit hyperactivity disorder, Polydipsia ORPHA:84081
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polyhydramnios, Hyperaldosteronism, Hydrops fetalis, Edema, Polydipsia OMIM:602522
Polydipsia, Dehydration ORPHA:2260
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Hypothyroidism, Abnormality of endocrine pancreas physiology, Abnormality of exocrine pancreas ph... ORPHA:93111
Erdheim-Chester Disease
Pleural effusion, Hyperhidrosis, Joint swelling, Polydipsia ORPHA:35687
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Toxic Epidermal Necrolysis
Gastrointestinal hemorrhage, Pancreatitis, Polydipsia, Dysphagia ORPHA:537
Distal Renal Tubular Acidosis
Vomiting, Diarrhea, Constipation, Dehydration, Polydipsia ORPHA:18
Hyperparathyroidism-Jaw Tumor Syndrome
Constipation, Dysphagia, Primary hyperparathyroidism, Pancreatitis, Polydipsia ORPHA:99880
Lambert-Eaton Myasthenic Syndrome
Constipation, Hypohidrosis, Xerostomia ORPHA:43393
Parathyroid Carcinoma
Constipation, Dysphagia, Primary hyperparathyroidism, Pancreatitis, Polydipsia ORPHA:143
Gitelman Syndrome
Hyperhidrosis, Diarrhea, Pericardial effusion, Primary hyperaldosteronism, Graves disease, Hashim... ORPHA:358
Juvenile Nephropathic Cystinosis
Hypothyroidism, Vomiting, Polydipsia, Dehydration ORPHA:411634
Rabson-Mendenhall Syndrome
Hypothyroidism, Polydipsia ORPHA:769
Wolfram Syndrome
Gastrointestinal hemorrhage, Constipation, Polydipsia ORPHA:3463
Cystinosis, Nephropathic
Hypohidrosis, Exocrine pancreatic insufficiency, Primary hypothyroidism, Dehydration, Dysphagia, ... OMIM:219800
Bartter Syndrome, Type 2, Antenatal
Polyhydramnios, Hyperaldosteronism, Vomiting, Diarrhea, Constipation, Dehydration, Polydipsia OMIM:241200
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Central hypothyroidism, Hypohidrosis, Increased circulating prolactin concentration, Gonadotropin... ORPHA:293987
Proximal Renal Tubular Acidosis
Vomiting, Diarrhea, Polydipsia, Dehydration ORPHA:47159
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Ascites, Polydipsia, Oligohydramnios ORPHA:731
Arima Syndrome
Polydipsia OMIM:243910


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chrm5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chrm5.

No publications found that use IMPC mice or data for Chrm5.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Chrm5tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Chrm5tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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