Gene: Sema4d

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Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
MGI ID
MGI:109244
Synonyms
Semaj Semacl2 Semcl2 semaphorin H M-sema G coll-4 CD100
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged heart Sema4dtm1b(EUCOMM)Wtsi HOM postnatal 0.00
cataract Sema4dtm1b(EUCOMM)Wtsi HOM postnatal 3.75×10-06
abnormal behavior Sema4dtm1b(EUCOMM)Wtsi HOM postnatal 6.10×10-05
enlarged spleen Sema4dtm1b(EUCOMM)Wtsi HOM postnatal 0.00
increased circulating alkaline phosphatase level Sema4dtm1b(EUCOMM)Wtsi HOM postnatal 7.05×10-08

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Select physiological systems to view:
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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (1/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (1/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (3/4) N/A
Foot 2  (1/485)  (1/4) N/A
Forebrain 2  (1/485)  (4/4) N/A
Forelimb 2  (1/485)  (1/4) N/A
Hand 2  (1/485)  (1/4) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485)  (1/4) N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485)  (1/4) N/A
Liver 2  (1/485)  (1/4) N/A
Lung 2  (1/485)  (1/4) N/A
Mandibular process 2  (1/485)  (1/4) N/A
Maxillary process 2  (1/485)  (1/4) N/A
Midbrain 2  (1/485)  (4/4) N/A
Oral cavity 2  (1/485)  (1/4) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485)  (2/4) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Echo: M-Mode Images
28 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
Adult LacZ: LacZ Images Wholemount
12 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sema4dtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sema4dtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sema4dtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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