Pkn2 | protein kinase N2

GeneMGI:109211Synonyms: Prkcl2, PRK2, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased exploration in new environment1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult3.63x10-11 
increased circulating bilirubin level1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult6.8x10-6 
decreased circulating HDL cholesterol level1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult3.79x10-5 
preweaning lethality, complete penetrance1 supporting datasetPkn2tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased circulating cholesterol level1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult1.59x10-5 
decreased circulating unsaturated transferrin level1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult1.18x10-7 
increased startle reflex1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult1.18x10-9 
decreased circulating total protein level1 supporting datasetPkn2tm1b(KOMP)WtsiheterozygoteEarly adult7.4x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pkn2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Pkn2tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pkn2tm1e(KOMP)WtsiTargeted, non-conditional allelees cell
Pkn2tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Pkn2tm3a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Pkn2tm3e(EUCOMM)WtsiTargeted, non-conditional allelees cell

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