Genes Phenotypes

Gene: Epas1

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Name
endothelial PAS domain protein 1
MGI ID
MGI:109169
Synonyms
HIF2A bHLHe73 MOP2 hypoxia inducible transcription factor 2alpha HIF-2alpha HLF Hif like protein HRF
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (233) All data table (415)
Expression & images (46) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Epas1tm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased circulating potassium level Epas1tm1b(EUCOMM)Hmgu HET Early adult 1.58×10-05
abnormal heart morphology Epas1tm1b(EUCOMM)Hmgu HET Early adult 0.00
increased circulating potassium level Epas1tm1b(EUCOMM)Hmgu HET Early adult 1.58×10-05
decreased hemoglobin content Epas1tm1b(EUCOMM)Hmgu HET Early adult 6.22×10-10

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (1/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (1/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
LacZ Wholemount Images
adipose tissue (4)
Brown adipose tissue expression
MA:0000057
cardiovascular system (14)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
digestive system (6)
Liver expression
Gall Bladder expression
Vascular System expression
MA:0000358
MA:0000356
MA:0002718
endocrine system (1)
Thyroid gland expression
Parathyroid gland expression
Trachea expression
Vascular System expression
Cartilage tissue expression
MA:0000129
MA:0000128
MA:0000441
MA:0002718
MA:0000104
exocrine system (2)
Prostate gland expression
Lower Urinary Tract expression
MA:0000404
MA:0002636
immune system (4)
Lymph Node expression
MA:0000139
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
Vascular System expression
Skeletal Muscle expression
Brown adipose tissue expression
MA:0000104
MA:0001459
MA:0002718
MA:0003148
MA:0000057
nervous system (5)
Olfactory Lobe expression
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Brain expression
MA:0002413
MA:0000185
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0000168
postnatal mouse (29)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
reproductive system (3)
Prostate gland expression
Lower Urinary Tract expression
MA:0000404
MA:0002636
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (5)
Brown adipose tissue expression
MA:0000057
trunk (16)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
29 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Epas1em2(IMPC)Wtsi Point Mutation Mice
Epas1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Epas1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Epas1em1(IMPC)Wtsi Point Mutation Mice

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