Genes Phenotypes

Gene: Epas1

Name
endothelial PAS domain protein 1
MGI ID
MGI:109169
Synonyms
HRF MOP2 HLF HIF2A HIF-2alpha Hif like protein bHLHe73 hypoxia inducible transcription factor 2alpha
Viability
N/A
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (235) All data table (357)
Expression & images (67) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal heart morphology Epas1tm1b(EUCOMM)Hmgu HET postnatal 0.00
decreased hemoglobin content Epas1tm1b(EUCOMM)Hmgu HET postnatal 6.34×10-10
preweaning lethality, complete penetrance Epas1tm1b(EUCOMM)Hmgu HOM n/a 0.00
increased circulating potassium level Epas1tm1b(EUCOMM)Hmgu HET postnatal 1.50×10-05
decreased circulating potassium level Epas1tm1b(EUCOMM)Hmgu HET postnatal 1.50×10-05

Download data as:  TSV  XLS

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (1/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (1/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
LacZ Wholemount Images
adipose tissue (4)
Brown adipose tissue expression
MA:0000057
cardiovascular system (14)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
digestive system (6)
Liver expression
Gall Bladder expression
Vascular System expression
MA:0000358
MA:0000356
MA:0002718
endocrine system (1)
Thyroid gland expression
Parathyroid gland expression
Trachea expression
Vascular System expression
Cartilage tissue expression
MA:0000129
MA:0000128
MA:0000441
MA:0002718
MA:0000104
exocrine system (2)
Prostate gland expression
Lower Urinary Tract expression
MA:0000404
MA:0002636
immune system (4)
Lymph Node expression
MA:0000139
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
Vascular System expression
Skeletal Muscle expression
Brown adipose tissue expression
MA:0000104
MA:0001459
MA:0002718
MA:0003148
MA:0000057
nervous system (5)
Olfactory Lobe expression
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Brain expression
MA:0002413
MA:0000185
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0000168
postnatal mouse (29)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
reproductive system (3)
Prostate gland expression
Lower Urinary Tract expression
MA:0000404
MA:0002636
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (5)
Brown adipose tissue expression
MA:0000057
trunk (16)
Aorta expression
Vascular System expression
Heart expression
MA:0000062
MA:0002718
MA:0000072
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (2/4) N/A
Ear 2  (1/485)  (1/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (1/4) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485)  (2/4) N/A
Forelimb 2  (1/485)  (2/4) N/A
Hand 2  (1/485) Image Only N/A
Head 2  (5/485)  (2/4) N/A
Heart 2  (1/485) Image Only N/A
Hindbrain 2  (6/485)  (2/4) N/A
Hindlimb 2  (1/485)  (2/4) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485)  (2/4) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485)  (1/4) N/A
Midbrain 2  (1/485)  (2/4) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485)  (2/4) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Lateral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
Adult LacZ: LacZ Images Wholemount
29 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Dorso Ventral
11 Images

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Epas1em1(IMPC)Wtsi Point Mutation Mice
Epas1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Epas1em2(IMPC)Wtsi Point Mutation Mice
Epas1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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