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Gene: Gng8 MGI:109163

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
guanine nucleotide binding protein (G protein), gamma 8
Synonyms:
G(y)8

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gng8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gng8 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Impaired social interactions, Compulsive behaviors OMIM:618830
Intellectual Developmental Disorder, Autosomal Recessive 66
Gait ataxia, Shyness, Attention deficit hyperactivity disorder, Aggressive behavior OMIM:618221
Asperger Syndrome, Susceptibility To, 1
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608631
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Intellectual Developmental Disorder With Autism And Speech Delay
Inability to walk, Abnormal repetitive mannerisms, Impaired social interactions OMIM:606053
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Unsteady gait, Impaired ability to form peer relationships, Impaired social... OMIM:608636
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Impulsivity, Abnormal eating behavior, Aggressive behavior, Compulsive behaviors, ... ORPHA:101039
Hsd10 Disease
Ataxia, Optic atrophy, Choreoathetosis, Gait disturbance, Dysphagia, Abnormal social behavior ORPHA:391417
11Q22.2Q22.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Abnormal social behavior, Depressed nasal bridge, Compu... ORPHA:444002
Lamb-Shaffer Syndrome
Hyperactivity, Ataxia, Broad nasal tip, Optic atrophy, Abnormal temper tantrums, Abnormal social ... ORPHA:530983
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior, Agitation, Ataxia, Disinhibition ORPHA:1020
Childhood Absence Epilepsy
Abnormal social behavior, Punding, Attention deficit hyperactivity disorder, Depression ORPHA:64280
Metachromatic Leukodystrophy, Late Infantile Form
Decreased nerve conduction velocity, Optic atrophy, Gait ataxia, Progressive gait ataxia, Tip-toe... ORPHA:309256
Metachromatic Leukodystrophy, Juvenile Form
Decreased nerve conduction velocity, Optic atrophy, Progressive gait ataxia, Emotional lability, ... ORPHA:309263
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Wide nose, Ataxia, Anteverted nares, Aggressive behavior, Bulbous nose, Unsteady gait, Dysmetria,... ORPHA:314647
Metachromatic Leukodystrophy, Adult Form
Decreased nerve conduction velocity, Optic atrophy, Depression, Progressive gait ataxia, Difficul... ORPHA:309271
Prader-Willi Syndrome Due To Translocation
Narrow nasal bridge, Anteverted nares, Prominent nose, Broad nasal tip, Head-banging, Lateral ven... ORPHA:177907
48,Xxxy Syndrome
Depressed nasal ridge, Irritability, Attention deficit hyperactivity disorder, Abnormal social be... ORPHA:96263
Fg Syndrome Type 1
Broad-based gait, Choanal atresia, Optic nerve hypoplasia, Prominent nose, Compulsive behaviors, ... ORPHA:93932
Dihydropyrimidine Dehydrogenase Deficiency
Depressed nasal bridge, Anteverted nares, Inability to walk, Irritability, Prominent nasal tip, A... ORPHA:1675
Mend Syndrome
Hyperactivity, Prominent nasal bridge, Abnormal auditory evoked potentials, Aggressive behavior, ... ORPHA:401973
Tuberous Sclerosis Complex
Hyperactivity, Impulsivity, Aggressive behavior, Repetitive compulsive behavior, Depression, Self... ORPHA:805
Niemann-Pick Disease Type C
Ataxia, Aggressive behavior, Depression, Progressive gait ataxia, Gait disturbance, Disinhibition... ORPHA:646
Koolen-De Vries Syndrome Due To A Point Mutation
Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous nose, Optic atrophy,... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Thick nasal alae, Prominent nasal bridge, Underdeveloped nasal alae, Bulbous nose, Optic atrophy,... ORPHA:363958
Williams Syndrome
Ataxia, Wide nasal bridge, Dysmetria, Depression, Gait disturbance, Gait imbalance, Attention def... ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gng8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gng8.

No publications found that use IMPC mice or data for Gng8.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gng8tm221812(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Gng8tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gng8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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