Gene: Ltbp1

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latent transforming growth factor beta binding protein 1
LTBP-1 Ltbp1L b2b1000Clo 9430031G15Rik
Embryo Screen
Other links
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal tooth morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 3.99×10-07
decreased bone mineral content Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 4.73×10-05
vertebral fusion Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 1.34×10-05
decreased body length Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 2.19×10-06
decreased circulating alanine transaminase level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 1.98×10-09
decreased total body fat amount Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 6.03×10-07
increased hemoglobin content Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 5.63×10-05
abnormal radius morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 4.27×10-08
increased blood urea nitrogen level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 6.09×10-06
preweaning lethality, incomplete penetrance Ltbp1tm1a(EUCOMM)Wtsi HOM n/a 0.00
decreased lean body mass Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 1.01×10-05
decreased circulating cholesterol level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 5.23×10-06
decreased body weight Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 1.94×10-13
decreased circulating aspartate transaminase level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 2.26×10-08
decreased circulating HDL cholesterol level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 8.02×10-05
abnormal ulna morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 1.50×10-07
abnormal incisor morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 3.82×10-06
abnormal snout morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 7.96×10-09
increased mean corpuscular hemoglobin Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 3.16×10-05
abnormal cranium morphology Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 4.09×10-08
decreased circulating LDL cholesterol level Ltbp1tm1a(EUCOMM)Wtsi HOM postnatal 3.22×10-06

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Select physiological systems to view:
Viewing: all phenotypes


IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (2/584) N/A
Aorta 3 No N/A
Blood vessel 3 No  (3/3) N/A
Bone 3 No N/A
Brain 3 No N/A
Brainstem 3 No N/A
Brown adipose tissue 3 No N/A
Cartilage tissue 3 No N/A
Cerebellum 3 No N/A
Cerebral cortex 3 No N/A
Eye 3 No N/A
Gall bladder 3 No  (2/3) N/A
Heart 3 No  (2/3) N/A
Hippocampus 3 No N/A
Hypothalamus 3 No N/A
Kidney 3 No  (18/584)  (1/3) N/A
Large intestine 3 No  (10/584) N/A
Liver 3 No  (1/3) N/A
Lower urinary tract 3 No  (2/3) N/A
Lung 3 No  (1/3) N/A
Lymph node 3 No N/A
Mammary gland 3 No N/A
Esophagus 3 No N/A
Olfactory lobe 3 No N/A
Ovary 3 No  (1/584)  (2/3) N/A
Oviduct 3 No  (2/3) N/A
Pancreas 3 No  (5/584) N/A
Parathyroid gland 3 No N/A
Peripheral nervous system 3 No N/A
Peyer's patch 3 No N/A
Pituitary gland 3 No N/A
Prostate gland 3 No  (12/584) N/A
Skeletal muscle tissue 3 No N/A
Skin 3 No N/A
Small intestine 3 No  (9/584)  (1/3) N/A
Spinal cord 3 No N/A
Spleen 3 No  (2/584) N/A
Stomach 3 No  (12/584)  (3/3) N/A
Striatum 3 No N/A
Testis 3 No  (2/584)  (1/3) N/A
Thymus 3 No N/A
Thyroid gland 3 No  (15/584)  (1/3) N/A
Trachea 3 No  (2/3) N/A
Uterus 3 No  (1/3) N/A
White adipose tissue 3 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Ltbp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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