Ltbp1 | latent transforming growth factor beta binding protein 1

GeneMGI:109151Synonyms: Ltbp1L, LTBP-1, +2 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Craniofacial Cardiovascular system

10 No significant impact

5 Not tested

Gene metrics:13Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal cranium morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult1.87x10-12 
abnormal snout morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult3.25x10-12 
decreased body weight4 supporting datasetsLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult1.03x10-13 
abnormal ulna morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult1.33x10-11 
abnormal incisor morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult1.73x10-6 
abnormal radius morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult1.77x10-12 
increased hemoglobin content1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult8.23x10-5 
increased circulating bilirubin level1 supporting datasetLtbp1tm1a(EUCOMM)WtsiheterozygoteEarly adult3.64x10-5 
abnormal tooth morphology1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult2.65x10-10 
vertebral fusion1 supporting datasetLtbp1tm1a(EUCOMM)WtsihomozygoteEarly adult5.49x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ltbp1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse

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