Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
max binding protein
Synonyms:
Rox,  bHLHd3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mnt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mnt by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pierre Robin Syndrome And Oligodactyly
Micrognathia, Cleft palate, Pierre-Robin sequence OMIM:172880
Neu-Laxova Syndrome 2
Micrognathia, Cleft palate, High palate, Intrauterine growth retardation, Microcephaly OMIM:616038
Orofacial Cleft 13
Micrognathia, Oligodontia, Cleft soft palate, Malar flattening, Retrognathia OMIM:613857
Cleft Palate-Lateral Synechia Syndrome
Micrognathia, Cleft palate, Narrow mouth, Everted lower lip vermilion, Oral synechia ORPHA:2016
Cleft Palate, Isolated
Micrognathia, Cleft palate, Gingival overgrowth, Increased overbite, Anterior open-bite malocclusion OMIM:119540
Auriculocondylar Syndrome 2
Mandibular condyle aplasia, Micrognathia, Cleft palate, Glossoptosis, Short mandibular rami, Macr... OMIM:614669
Cleft Velum
Cleft soft palate, Hypoplasia of the maxilla, Velopharyngeal insufficiency, Oral-pharyngeal dysph... ORPHA:99772
Lowry-Maclean Syndrome
Microcephaly, Cleft palate, Intrauterine growth retardation, Delayed eruption of teeth OMIM:600252
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Micrognathia, Cleft palate, Mandibular prognathia, Bifid uvula, Retrognathia, Submucous cleft har... ORPHA:2521
Cleft Lip/Palate
Peg-shaped maxillary lateral incisors, Agenesis of lateral incisor, Cleft palate, Palate fistula,... ORPHA:199306
Auriculocondylar Syndrome 3
Glossoptosis, Micrognathia, Bifid uvula, Retrognathia OMIM:615706
Epidermolysis Bullosa, Late-Onset Localized Junctional, With Mental Retardation
Cleft palate, Short philtrum, Mandibular prognathia, Thick upper lip vermilion, Thin upper lip ve... OMIM:226440
Hamel Cerebro-Palato-Cardiac Syndrome
Micrognathia, Cleft palate, Death in infancy, Malar flattening, Narrow mouth, Microcephaly ORPHA:93946
Microphthalmia, Syndromic 8
Cleft palate, Mandibular prognathia, Cleft upper lip, Widely-spaced maxillary central incisors, M... OMIM:601349
Auriculocondylar Syndrome 1
Mandibular condyle aplasia, Micrognathia, Cleft palate, Impaired mastication, Glossoptosis, Anter... OMIM:602483
Cleft Palate, Deafness, And Oligodontia
Cleft soft palate, Oligodontia of primary teeth, No permanent dentition OMIM:216300
Robinow Syndrome, Autosomal Dominant 2
Micrognathia, Dental crowding, Long philtrum, Cleft soft palate, Gingival overgrowth, Macrocephal... OMIM:616331
Orofaciodigital Syndrome Type 5
High, narrow palate, Hypodontia, Aganglionic megacolon, Agenesis of canine, Absent cupid's bow, C... ORPHA:2919
Tetraploidy
Micrognathia, Cleft palate, Intrauterine growth retardation, Short philtrum, Biparietal narrowing... ORPHA:3305
Auriculocondylar Syndrome
Mandibular condyle aplasia, Micrognathia, Cleft palate, Dental crowding, Hamartoma of tongue, Mic... ORPHA:137888
Birk-Barel Syndrome
Dysphagia, High palate, Short philtrum, Bifid uvula, Tented upper lip vermilion, Submucous cleft ... OMIM:612292
Amish Lethal Microcephaly
Cleft soft palate, Micrognathia, Death in infancy, Microcephaly ORPHA:99742
Lethal Omphalocele-Cleft Palate Syndrome
Cleft palate, Cleft soft palate, Bifid uvula, Unilateral cleft lip, Retrognathia ORPHA:2736
Cleft Soft Palate
Cleft soft palate OMIM:119570
Van Der Woude Syndrome 1
Hypodontia, Cleft palate, Cleft upper lip, Lower lip pit, Bifid uvula OMIM:119300
Chromosome 17Q12 Duplication Syndrome
Cleft soft palate, Micrognathia, Smooth philtrum, Esophageal atresia OMIM:614526
Multiple Epiphyseal Dysplasia, Lowry Type
Micrognathia, Cleft hard palate ORPHA:166016
Craniolenticulosutural Dysplasia
Carious teeth, Cleft palate, Smooth philtrum, Wide mouth, Long philtrum, Malar flattening, Bifid ... OMIM:607812
Coffin-Siris Syndrome 11
High palate, Wide mouth, Cleft soft palate, Esophageal atresia, Bifid uvula, Downturned corners o... OMIM:618779
Craniosynostosis 2
Cleft soft palate, Supernumerary tooth OMIM:604757
Cree Mental Retardation Syndrome
Cleft soft palate, Micrognathia OMIM:606851
Blepharophimosis-Intellectual Disability Syndrome, Verloes Type
Smooth philtrum, Short philtrum, Cleft soft palate, Primary microcephaly, Retrognathia ORPHA:293725
Cerebrocostomandibular Syndrome
Micrognathia, High palate, Long philtrum, Cleft soft palate, Malar flattening, Glossoptosis, Abno... OMIM:117650
Orofaciodigital Syndrome Type 10
Micrognathia, Long philtrum, Cleft soft palate, Accessory oral frenulum, Retrognathia ORPHA:2756
Dysmorphism-Short Stature-Deafness-Disorder Of Sex Development Syndrome
Micrognathia, Intrauterine growth retardation, Cleft soft palate, Submucous cleft soft palate, Mi... ORPHA:2282
Loeys-Dietz Syndrome 5
Smooth philtrum, High palate, Cleft palate, Cleft soft palate, Bifid uvula, Tented upper lip verm... OMIM:615582
Midface Hypoplasia, Hearing Impairment, Elliptocytosis, And Nephrocalcinosis
Micrognathia, Submucous cleft hard palate, Bifid uvula, Delayed eruption of teeth, Narrow mouth, ... OMIM:300990
Branchiooculofacial Syndrome
Pyloric stenosis, Micrognathia, Cleft palate, Intrauterine growth retardation, Cleft upper lip, L... OMIM:113620
Treacher Collins Syndrome 1
Micrognathia, Cleft palate, Wide mouth, Cleft soft palate, Abnormal parotid gland morphology, Mal... OMIM:154500
Saethre-Chotzen Syndrome
Cleft palate, Malar flattening, Narrow palate, Cleft of chin, Hypoplasia of the maxilla OMIM:101400
Limb-Mammary Syndrome
Hypodontia, Cleft palate, Malar flattening, Bifid uvula, Cleft lip, Submucous cleft soft palate, ... ORPHA:69085
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies
Smooth philtrum, Intrauterine growth retardation, Cleft soft palate, Intestinal malrotation, Down... OMIM:619321
Viss Syndrome
High, narrow palate, Micrognathia, High palate, Malposition of the stomach, Dysphagia, Celiac dis... OMIM:619472

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mnt

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mnt.

No publications found that use IMPC mice or data for Mnt.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Mnttm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Mnttm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter