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Gene: Mnt MGI:109150

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
max binding protein
Synonyms:
Rox,  bHLHd3

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mnt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mnt by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pierre Robin Syndrome
Glossoptosis, Pierre-Robin sequence, Cleft palate, Micrognathia OMIM:261800
Pierre Robin Syndrome And Oligodactyly
Pierre-Robin sequence, Cleft palate, Micrognathia OMIM:172880
Isolated Pierre Robin Syndrome
Glossoptosis, Cleft palate, Micrognathia ORPHA:718
Cleft Palate-Lateral Synechia Syndrome
Micrognathia, Cleft palate, Everted lower lip vermilion, Narrow mouth, Oral synechia ORPHA:2016
Cleft Palate, Isolated
Micrognathia, Gingival overgrowth, Cleft palate, Anterior open-bite malocclusion, Increased overbite OMIM:119540
Auriculocondylar Syndrome 2A
Dental crowding, Micrognathia, Microglossia, Dental malocclusion, Cleft palate, Mandibular condyl... OMIM:614669
Cleft Lip/Palate
Agenesis of lateral incisor, Bilateral cleft palate, Oral-pharyngeal dysphagia, Hypoplasia of the... ORPHA:199306
Catifa Syndrome
Delayed eruption of teeth, Cleft lip, Cleft palate, Mild microcephaly, Increased overbite, Long p... OMIM:618761
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Mandibular prognathia, Micrognathia, Microcephaly, Submucous cleft hard palate, Cleft palate, Ret... ORPHA:2521
Lowry-Maclean Syndrome
Delayed eruption of teeth, Intrauterine growth retardation, Cleft palate, Microcephaly OMIM:600252
Orofacial Cleft 13
Cleft soft palate, Micrognathia, Oligodontia, Malar flattening, Retrognathia OMIM:613857
Teebi Hypertelorism Syndrome 2
Delayed eruption of teeth, Thin upper lip vermilion, Wide anterior fontanel, Cleft palate, Everte... OMIM:619736
Hamel Cerebro-Palato-Cardiac Syndrome
Death in infancy, Micrognathia, Microcephaly, Cleft palate, Narrow mouth, Malar flattening ORPHA:93946
Microphthalmia, Syndromic 8
Mandibular prognathia, Cleft upper lip, Microcephaly, Cleft palate, Orofacial cleft, Widely-space... OMIM:601349
Microphthalmia, Syndromic 12
Intestinal malrotation, Micrognathia, Cleft palate, Neonatal death, Retrognathia OMIM:615524
Cleft Velum
Hypoplasia of the maxilla, Velopharyngeal insufficiency, Cleft soft palate, Oral-pharyngeal dysph... ORPHA:99772
Contractures, Congenital, Torticollis, And Malignant Hyperthermia
Natal tooth, Abnormal mandible morphology, Cleft palate OMIM:217150
Auriculocondylar Syndrome 1
Dental crowding, Micrognathia, Dental malocclusion, Cleft palate, Mandibular condyle hypoplasia, ... OMIM:602483
Orofaciodigital Syndrome Type 5
Median cleft lip, Abnormality of the philtrum, Cleft soft palate, Accessory oral frenulum, Agangl... ORPHA:2919
Braddock-Carey Syndrome 2
Microcephaly, Pierre-Robin sequence, Cleft palate, Wide mouth, Retrognathia OMIM:619981
Tetraploidy
Microcephaly, Micrognathia, Cleft palate, Short philtrum, Biparietal narrowing, Intrauterine grow... ORPHA:3305
Birk-Barel Syndrome
Microretrognathia, Tented upper lip vermilion, High palate, Short philtrum, Dysphagia, Submucous ... OMIM:612292
Van Der Woude Syndrome 2
Lip pit, Cleft upper lip, Dental malocclusion, Cleft palate, Hypodontia, Anodontia OMIM:606713
Auriculocondylar Syndrome
Abnormality of the temporomandibular joint, Dental crowding, Hamartoma of tongue, Micrognathia, N... ORPHA:137888
Cleft Palate, Deafness, And Oligodontia
No permanent dentition, Oligodontia of primary teeth, Cleft soft palate OMIM:216300
Robinow Syndrome, Autosomal Dominant 2
Thin upper lip vermilion, Dental crowding, Cleft soft palate, Abnormality of the dentition, Micro... OMIM:616331
Orofaciodigital Syndrome Xix
Cleft soft palate, Accessory oral frenulum, Carious teeth, Retrognathia, Narrow palate, Downturne... OMIM:620107
Treacher Collins Syndrome 3
Malar flattening, Hypoplasia of the zygomatic bone, Cleft palate, Micrognathia OMIM:248390
Lethal Omphalocele-Cleft Palate Syndrome
Cleft soft palate, Cleft palate, Unilateral cleft lip, Retrognathia, Bifid uvula ORPHA:2736
Acrocallosal Syndrome
Mandibular prognathia, Downturned corners of mouth, High palate, Short philtrum, Prominent palati... OMIM:200990
Robinow Syndrome, Autosomal Recessive 2
Relative macrocephaly, Cleft soft palate, Abnormality of the dentition, Micrognathia, Gingival ov... OMIM:618529
Amish Lethal Microcephaly
Death in infancy, Microcephaly, Cleft soft palate, Micrognathia ORPHA:99742
Craniolenticulosutural Dysplasia
Delayed eruption of teeth, Thin upper lip vermilion, Carious teeth, Wide anterior fontanel, Cleft... OMIM:607812
Chromosome 17Q12 Duplication Syndrome
Esophageal atresia, Cleft soft palate, Smooth philtrum, Micrognathia OMIM:614526
Multiple Epiphyseal Dysplasia, Lowry Type
Cleft hard palate, Micrognathia ORPHA:166016
Coffin-Siris Syndrome 11
Cleft soft palate, Esophageal atresia, Downturned corners of mouth, Wide mouth, High palate, Bifi... OMIM:618779
Robin Sequence With Distinctive Facial Appearance And Brachydactyly
Exaggerated median tongue furrow, Tented upper lip vermilion, Exaggerated cupid's bow, Micrognath... OMIM:608670
Microcephaly 30, Primary, Autosomal Recessive
Thin upper lip vermilion, Cleft soft palate, Pierre-Robin sequence, Primary microcephaly, Intraut... OMIM:620183
Cerebrocostomandibular Syndrome
Anal stenosis, Cleft soft palate, Micrognathia, Carious teeth, Cleft lip, Microcephaly, Pierre-Ro... OMIM:117650
Blepharophimosis-Intellectual Disability Syndrome, Verloes Type
Cleft soft palate, Short philtrum, Primary microcephaly, Retrognathia, Smooth philtrum ORPHA:293725
Tessadori-Bicknell-Van Haaften Neurodevelopmental Syndrome 3
Mandibular prognathia, High, narrow palate, Deep philtrum, Downturned corners of mouth, Short phi... OMIM:619950
Orofaciodigital Syndrome Type 10
Cleft soft palate, Accessory oral frenulum, Micrognathia, Long philtrum, Retrognathia ORPHA:2756
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome
Delayed eruption of teeth, Abnormal dental enamel morphology, Conical tooth, Micrognathia, Non-mi... ORPHA:1071
Orofaciodigital Syndrome Type 2
Natal tooth, Median cleft lip, Hamartoma of tongue, Micrognathia, Unilateral alveolar cleft of ma... ORPHA:2751
Craniosynostosis 2
Supernumerary tooth, Cleft soft palate OMIM:604757
Cree Mental Retardation Syndrome
Cleft soft palate, Micrognathia OMIM:606851
Dysmorphism-Short Stature-Deafness-Difference Of Sex Development Syndrome
Cleft soft palate, Microcephaly, Micrognathia, Submucous cleft soft palate, Intrauterine growth r... ORPHA:2282
Loeys-Dietz Syndrome 5
Tented upper lip vermilion, Cleft soft palate, Eosinophilic infiltration of the esophagus, Hiatus... OMIM:615582
Cleft Soft Palate
Cleft soft palate OMIM:119570
Spondylometaphyseal Dysplasia, Schmidt Type
Cleft soft palate, Micrognathia ORPHA:93316
Bifid Uvula
Submucous cleft soft palate, Cleft lip, Bifid uvula ORPHA:99771
Native American Myopathy
Micrognathia, Cleft palate, Downturned corners of mouth, High palate, Submucous cleft soft palate... ORPHA:168572
Intellectual Developmental Disorder, X-Linked, Syndromic 34
Relative macrocephaly, Dental crowding, Impulsivity, Aggressive behavior, High, narrow palate, Ma... OMIM:300967
Treacher Collins Syndrome 1
Cleft soft palate, Micrognathia, Cleft palate, Wide mouth, Abnormal parotid gland morphology, Nar... OMIM:154500
Midface Hypoplasia, Hearing Impairment, Elliptocytosis, And Nephrocalcinosis
Delayed eruption of teeth, Thin upper lip vermilion, Dental crowding, Micrognathia, Cleft hard pa... OMIM:300990
Branchiooculofacial Syndrome
Abnormality of the dentition, Malrotation of colon, Cleft upper lip, Lower lip pit, Pyloric steno... OMIM:113620
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Cleft soft palate, Aggressive behavior, Microcephaly, Pyloric stenosis, Supernumerary tooth, Wide... ORPHA:268261
Saethre-Chotzen Syndrome
Hypoplasia of the maxilla, Cleft of chin, Cleft palate, Narrow palate, Malar flattening OMIM:101400
Limb-Mammary Syndrome
Cleft hard palate, Cleft lip, Cleft palate, Hypodontia, Submucous cleft soft palate, Malar flatte... ORPHA:69085
Diamond-Blackfan Anemia
Cleft soft palate, Micrognathia, Microcephaly, Cleft lip, High palate, Adenocarcinoma of the colon ORPHA:124
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Delayed eruption of teeth, Thin upper lip vermilion, Mandibular prognathia, Dental crowding, Clef... OMIM:619503
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies
Intestinal malrotation, Cleft soft palate, Microcephaly, Downturned corners of mouth, Intrauterin... OMIM:619321
Viss Syndrome
Microretrognathia, Chronic gastritis, Duodenitis, Intestinal malrotation, Cleft soft palate, Subm... OMIM:619472
Hardikar Syndrome
Cleft soft palate, Intestinal malrotation, Celiac disease, Esophageal varix, Bilateral cleft lip ... OMIM:301068
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Delayed eruption of teeth, Mandibular prognathia, Aganglionic megacolon, Dental crowding, Abnorma... ORPHA:261537
Mowat-Wilson Syndrome
Mandibular prognathia, Dental crowding, Cleft hard palate, Widely spaced teeth, Abnormal repetiti... ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Mandibular prognathia, Dental crowding, Cleft hard palate, Short philtrum, Abnormal repetitive ma... ORPHA:261552
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2
Cleft soft palate OMIM:614557

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mnt

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mnt.

No publications found that use IMPC mice or data for Mnt.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mnttm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Mnttm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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