Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
vascular endothelial growth factor C
Synonyms:
VEGF-C

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vegfc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Vegfc by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lymphatic Malformation 4
Lymphedema OMIM:615907
Milroy Disease
Lymphedema, Pedal edema, Predominantly lower limb lymphedema ORPHA:79452

The table below shows human diseases predicted to be associated to Vegfc by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nuchal Bleb, Familial
Hydrops fetalis, Fetal cystic hygroma, Stillbirth OMIM:257350
Lymphatic Malformation 9
Predominantly lower limb lymphedema, Tortuous lymphatic vessels OMIM:619319
Lymphatic Malformation 11
Lymphedema, Pedal edema OMIM:619401
Gjc2-Related Late-Onset Primary Lymphedema
Edema of the dorsum of hands, Abnormal lymphatic vessel morphology, Hypoplasia of lymphatic vesse... ORPHA:568051
Lymphedema And Cerebral Arteriovenous Anomaly
Pulmonary arterial hypertension, Lymphedema OMIM:152900
Ascites, Chylous
Chylous ascites OMIM:208300
Lymphatic Malformation 2
Lymphedema OMIM:611944
Lymphangioleiomyomatosis
Pulmonary lymphangiomyomatosis OMIM:606690
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
Lymphedema-Cerebral Arteriovenous Anomaly Syndrome
Lymphedema ORPHA:86914
Lymphatic Malformation 5
Predominantly lower limb lymphedema, Hypoplasia of lymphatic vessels, Facial edema OMIM:153200
Yellow Nail Syndrome
Lymphedema, Hypoplasia of lymphatic vessels, Predominantly lower limb lymphedema OMIM:153300
Lymphatic Malformation 3
Lymphedema OMIM:613480
Corneal Dystrophy, Fuchs Endothelial, 3
Edema OMIM:613267
Hydrops Fetalis, Nonimmune
Hydrops fetalis, Nonimmune hydrops fetalis OMIM:236750
Chylous Ascites
Lymphedema, Ascites ORPHA:1160
Lymphatic Malformation 8
Polyhydramnios, Stillbirth, Pleural effusion, Pericardial effusion, Nonimmune hydrops fetalis, Ge... OMIM:618773
Secondary Intestinal Lymphangiectasia
Lymphedema, Pleural effusion, Pedal edema, Chylous ascites, Abnormality of the lymphatic system ORPHA:90363
Lymphangiectasia, Pulmonary, Congenital
Polyhydramnios, Palpebral edema, Pleural effusion, Pedal edema, Facial edema, Edema, Ascites, Non... OMIM:265300
Fetal Parvovirus Syndrome
Increased nuchal translucency, Hydrops fetalis, Ascites, Hypertrophic cardiomyopathy ORPHA:295
Lymphatic Malformation 1
Hyperkeratosis over edematous areas, Hypoplasia of lymphatic vessels, Predominantly lower limb ly... OMIM:153100
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
Polyhydramnios, Hydrops fetalis, Nonimmune hydrops fetalis OMIM:613124
Choanal Atresia And Lymphedema
Lymphedema, Pericardial effusion OMIM:613611
Follicular Lymphoma
Lymphedema, Pleural effusion, Splenomegaly, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:545
Hydrops Fetalis
Polyhydramnios, Arrhythmia, Lymphedema, Pleural effusion, Pericardial effusion, Ascites, Nonimmun... ORPHA:1041
German Syndrome
Lymphedema OMIM:231080
Alg8-Cdg
Lymphedema ORPHA:79325
Ovarian Hyperstimulation Syndrome
Ascites OMIM:608115
Meige Disease
Edema of the dorsum of hands, Lymphedema, Pleural effusion, Peripheral edema, Pedal edema, Lymph ... ORPHA:90186
Congenital Pulmonary Lymphangiectasia
Hydrops fetalis, Pleural effusion, Tricuspid regurgitation, Hepatomegaly, Pulmonic stenosis, Cong... ORPHA:2414
Mpi-Cdg
Lymphedema ORPHA:79319
Lymphatic Malformation 10
Lymphedema OMIM:619369
Lymphatic Malformation 7
Lymphedema, Pericardial effusion, Facial edema, Edema, Nonimmune hydrops fetalis, Pulmonary edema OMIM:617300
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hydrops fetalis, Palpebral edema, Plantar telangiectasia, Pleural effusion, Predominantly lower l... ORPHA:69735
Primary Intestinal Lymphangiectasia
Hydrops fetalis, Lymphedema, Pleural effusion, Pericardial effusion, Pedal edema, Chylous ascites... ORPHA:90362
Hemolytic Anemia, Lethal Congenital Nonspherocytic, With Genital And Other Abnormalities
Hepatosplenomegaly, Ascites OMIM:600461
Cholestasis-Lymphedema Syndrome
Lymphedema, Splenomegaly, Hepatomegaly OMIM:214900
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Lymphedema, Edema, Facial edema OMIM:618154
Dysplastic Cortical Hyperostosis
Polyhydramnios, Hydrops fetalis, Splenomegaly ORPHA:2204
Lymphangiectasia, Intestinal
Intestinal lymphangiectasia, Pedal edema, Edema, Stillbirth OMIM:152800
Hennekam Lymphangiectasia-Lymphedema Syndrome 2
Lymphedema, Pericardial lymphangiectasia, Intestinal lymphangiectasia, Pulmonary lymphangiectasia OMIM:616006
Achondrogenesis, Type Ib
Polyhydramnios, Hydrops fetalis, Stillbirth, Edema, Breech presentation OMIM:600972
Chondrodysplasia, Blomstrand Type
Polyhydramnios, Hydrops fetalis, Premature birth, Stillbirth OMIM:215045
Lymphatic Malformation 4
Lymphedema OMIM:615907
Nephrosialidosis
Pericardial effusion, Ascites OMIM:256150
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death, Hydrops fetalis OMIM:276822
Lissencephaly 2
Lymphedema OMIM:257320
Diffuse Neonatal Hemangiomatosis
Polyhydramnios, Hydrops fetalis, Patent ductus arteriosus, Premature birth, Ascites ORPHA:2123
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Polyhydramnios, Abnormal aortic morphology, Hydrops fetalis, Single umbilical artery ORPHA:3405
Hb Bart'S Hydrops Fetalis
Polyhydramnios, Hydrops fetalis, Oligohydramnios, Preeclampsia, Splenomegaly ORPHA:163596
Alpha-Heavy Chain Disease
Hepatomegaly, Ascites, Lymphadenopathy, Splenomegaly ORPHA:100025
Cholestasis-Lymphedema Syndrome
Gastrointestinal hemorrhage, Lymphedema, Hepatomegaly, Splenomegaly, Portal hypertension, Abnorma... ORPHA:1414
Indomethacin Embryofetopathy
Hydrops fetalis, Premature birth, Oligohydramnios ORPHA:1909
Developmental And Epileptic Encephalopathy 96
Hydrops fetalis OMIM:619340
Anemia, Congenital Dyserythropoietic, Type Iv
Hydrops fetalis, Splenomegaly OMIM:613673
Splenoportal Vascular Anomalies
Ascites, Splenomegaly OMIM:271500
Cardiomyopathy, Familial Hypertrophic, 4
Right bundle branch block, Pericardial effusion, Left bundle branch block, Hepatomegaly, Atrioven... OMIM:115197
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Hepatomegaly, Ascites, Gastrointestinal hemorrhage ORPHA:2198
Lymphatic Malformation 6
Polyhydramnios, Lymphedema, Pleural effusion, Facial edema, Splenomegaly, Edema, Ascites, Nonimmu... OMIM:616843
Glycogen Storage Disease Iv
Polyhydramnios, Hydrops fetalis, Edema, Ascites, Portal hypertension, Hepatosplenomegaly, Cardiom... OMIM:232500
Campomelia, Cumming Type
Lymphedema, Polysplenia OMIM:211890
Lymphedema, Primary, With Myelodysplasia
Lymphedema OMIM:614038
Lissencephaly 7 With Cerebellar Hypoplasia
Lymphedema OMIM:616342
Chilblain Lupus 2
Vasculitis, Edema OMIM:614415
Transaldolase Deficiency
Hepatosplenomegaly, Hydrops fetalis, Edema, Coarctation of aorta ORPHA:101028
Fetal Gaucher Disease
Hydrops fetalis, Stillbirth, Fetal akinesia sequence, Decreased fetal movement, Neonatal death, S... ORPHA:85212
Alpha-Thalassemia
Hydrops fetalis, Hypersplenism, Splenomegaly ORPHA:846
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
Lymphedema, Telangiectasia of the skin, Hepatomegaly, Telangiectasia, Hypertrophic cardiomyopathy ORPHA:79279
Pulmonary Edema Of Mountaineers, Susceptibility To
Edema, Pulmonary edema, Elevated pulmonary artery pressure OMIM:178400
Congenital Disorder Of Glycosylation, Type Ik
Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly OMIM:608540
Lethal Hemolytic Anemia-Genital Anomalies Syndrome
Polyhydramnios, Ascites, Oligohydramnios, Splenomegaly ORPHA:1046
Pseudomyxoma Peritonei
Ascites, Lymphadenopathy ORPHA:26790
Sialidosis Type 2
Hydrops fetalis, Pedal edema, Hepatomegaly, Ascites, Splenomegaly ORPHA:87876
Deafness-Lymphedema-Leukemia Syndrome
Intracranial hemorrhage, Lymphedema, Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:3226
Cinca Syndrome
Lymphedema, Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Agenesis Of The Corpus Callosum And Congenital Lymphedema
Pulmonary arterial hypertension, Oligohydramnios, Lymphedema, Hypertension OMIM:613623
Hepatic Veno-Occlusive Disease
Hepatomegaly, Ascites ORPHA:890
Dohle Bodies And Leukemia
Lymphedema OMIM:223350
Familial Atrial Myxoma
Pedal edema, Tricuspid regurgitation, Heart murmur, Congestive heart failure, Ascites ORPHA:615
Melorheostosis
Lymphedema ORPHA:2485
Combined Oxidative Phosphorylation Deficiency 5
Edema, Ascites, Hypertrophic cardiomyopathy OMIM:611719
Infantile Sialic Acid Storage Disease
Hydrops fetalis, Hepatomegaly, Congestive heart failure, Ascites, Splenomegaly OMIM:269920
Kaposi Sarcoma
Lymphedema, Abnormality of the spleen, Generalized lymphadenopathy ORPHA:33276
Al-Gazali-Bakalinova Syndrome
Lymphedema OMIM:607131
Cardiomyopathy, Familial Hypertrophic 27
Hydrops fetalis OMIM:618052
Hypervitaminosis A, Susceptibility To
Ascites OMIM:240150
Klippel-Trénaunay Syndrome
Hydrops fetalis, Gastrointestinal hemorrhage, Internal hemorrhage, Hepatomegaly, Pulmonary emboli... ORPHA:90308
Milroy Disease
Lymphedema, Pedal edema, Predominantly lower limb lymphedema ORPHA:79452
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Ascites OMIM:174050
Idiopathic Neonatal Atrial Flutter
Hydrops fetalis, Fetal distress, Maternal diabetes ORPHA:45452
Greenberg Dysplasia
Lymphedema ORPHA:1426
Achondrogenesis
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:932
Anemia, Congenital Dyserythropoietic, Type Ia
Hydrops fetalis, Splenomegaly OMIM:224120
Achondrogenesis, Type Ii
Polyhydramnios, Hydrops fetalis, Edema, Stillbirth OMIM:200610
Yellow Nail Syndrome
Pulmonary arterial hypertension, Lymphedema, Hypoplasia of lymphatic vessels ORPHA:662
Lymphedema-Hypoparathyroidism Syndrome
Lymphedema, Pulmonary lymphangiectasia OMIM:247410
Congenital Toxoplasmosis
Hepatomegaly, Ascites, Lymphadenopathy ORPHA:858
Hypotrichosis-Lymphedema-Telangiectasia Syndrome
Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Palmar telangiectasia, Palpebral ... OMIM:607823
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Lymphedema ORPHA:1116
Hemochromatosis, Type 1
Arrhythmia, Pleural effusion, Hepatomegaly, Congestive heart failure, Ascites, Splenomegaly, Tela... OMIM:235200
Chromosome 1P36.33 Duplication Syndrome, Atad3 Gene Cluster, Autosomal Dominant
Hydrops fetalis, Fetal akinesia sequence OMIM:618815
Capillary Malformation Of The Lower Lip, Lymphatic Malformation Of Face And Neck, Asymmetry Of Face And Limbs, And Partial/Generalized Overgrowth
Lymphedema OMIM:613089
Neuraminidase Deficiency
Hydrops fetalis, Facial edema, Hepatomegaly, Ascites, Splenomegaly, Cardiomyopathy OMIM:256550
Ovarian Hyperstimulation Syndrome
Hypovolemia, Pleural effusion, Peripheral edema, Ascites, Pulmonary edema, Generalized edema, Cap... ORPHA:64739
Lymphedema, Cardiac Septal Defects, And Characteristic Facies
Lymphedema, Atrial flutter, Oligohydramnios, Severe hydrops fetalis OMIM:601927
Maternal Uniparental Disomy Of Chromosome X
Congestive heart failure, Predominantly lower limb lymphedema ORPHA:261519
Achondrogenesis Type 1B
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:93298
Congenital Disorder Of Glycosylation, Type Iir
Hepatomegaly, Ascites OMIM:301045
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Polyhydramnios, Pancreatic lymphangiectasis, Lymphedema, Hepatomegaly, Thyroid lymphangiectasia, ... OMIM:235255
Kaposiform Lymphangiomatosis
Pleural effusion, Pericardial effusion, Abnormal lymphatic vessel morphology, Abnormal spleen mor... ORPHA:464329
Klippel-Trenaunay-Weber Syndrome
Lymphedema, Lymphangioma OMIM:149000
Lymphoproliferative Syndrome 2
Hepatomegaly, Ascites, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy OMIM:615122
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death, Nonimmune hydrops fetalis OMIM:619003
Chromomycosis
Lymphedema, Lymphangiectasis, Edema, Predominantly lower limb lymphedema ORPHA:182
Boomerang Dysplasia
Polyhydramnios, Hydrops fetalis ORPHA:1263
Achondrogenesis Type 1A
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:93299
Alpha-N-Acetylgalactosaminidase Deficiency
Lymphedema ORPHA:3137
Capillary Malformation-Arteriovenous Malformation
Lymphedema, Epistaxis, Chylothorax, Congestive heart failure, Cerebral ischemia, Nonimmune hydrop... ORPHA:137667
Mucopolysaccharidosis Type 7
Lymphedema, Hydrops fetalis, Ascites, Splenomegaly ORPHA:584
Malignant Peritoneal Mesothelioma
Pedal edema, Ascites ORPHA:168811
Cronkhite-Canada Syndrome
Lymphedema, Splenomegaly, Hepatomegaly ORPHA:2930
Congenital Disorder Of Glycosylation, Type Il
Pericardial effusion, Hepatomegaly, Edema, Ascites, Hepatosplenomegaly OMIM:608776
Congenital Disorder Of Glycosylation, Type Ib
Lymphangiectasis OMIM:602579
Pigmented Villonodular Synovitis
Lymphedema, Joint swelling ORPHA:66627
Lymphedema-Distichiasis Syndrome
Lymphedema, Arrhythmia, Predominantly lower limb lymphedema OMIM:153400
Tempi Syndrome
Intracranial hemorrhage, Ascites, Telangiectasia, Transudative pleural effusion ORPHA:284227
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Hydrops fetalis, Splenomegaly ORPHA:766
Glycogen Storage Disease Of Heart, Lethal Congenital
Hypotension, Congestive heart failure, Shortened PR interval, Ascites, Pulmonary edema, Bradycard... OMIM:261740
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Ascites OMIM:617156
Monosomy 18P
Lymphedema, Hypertension ORPHA:1598
Dengue Fever
Gastrointestinal hemorrhage, Hypotension, Epistaxis, Hepatomegaly, Cerebral hemorrhage, Ascites ORPHA:99828
German Syndrome
Lymphedema ORPHA:2077
Fabry Disease
Arrhythmia, Angina pectoris, Lymphedema, Hypertension, Myocardial infarction, Congestive heart fa... OMIM:301500
Desmoplastic Small Round Cell Tumor
Hepatomegaly, Mediastinal lymphadenopathy, Ascites, Lymphadenopathy ORPHA:83469
Xfe Progeroid Syndrome
Ascites, Hypertension OMIM:610965
Ovarian Fibroma
Pleural effusion, Ascites ORPHA:314473
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Facial telangiectasia in butterfly midface distribution, Palpebral edema, Lymphedema, Pulmonary l... OMIM:137940
Aplasia Cutis Congenita With Intestinal Lymphangiectasia
Intestinal lymphangiectasia, Generalized edema OMIM:207731
Combined Oxidative Phosphorylation Defect Type 27
Nonimmune hydrops fetalis ORPHA:477774
Ring Chromosome 22 Syndrome
Lymphedema, Pleural effusion, Edema ORPHA:1446
Hemochromatosis, Neonatal
Nonimmune hydrops fetalis, Oligohydramnios OMIM:231100
Minicore Myopathy With External Ophthalmoplegia
Polyhydramnios, Decreased fetal movement, Hydrops fetalis OMIM:255320
Parkes Weber Syndrome
Arteriovenous fistula, Cerebral arteriovenous malformation, Abnormal lymphatic vessel morphology,... ORPHA:90307
Wolman Disease
Hepatomegaly, Ascites, Splenomegaly ORPHA:75233
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Budd-Chiari syndrome, Hepatomegaly, Pulmonary embolism, Edema, Ascites, Generalized edema OMIM:226300
Mulibrey Nanism
Hepatomegaly, Congestive heart failure, Hydrops fetalis, Ascites OMIM:253250
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Polyhydramnios, Hepatomegaly, Congestive heart failure, Ascites, Nonimmune hydrops fetalis, Dilat... ORPHA:367
Cantu Syndrome
Lymphedema, Pericardial effusion OMIM:239850
Free Sialic Acid Storage Disease
Hepatomegaly, Hydrops fetalis, Ascites, Splenomegaly ORPHA:834
Hypocomplementemic Urticarial Vasculitis
Small vessel vasculitis, Pleural effusion, Pericardial effusion, Hepatomegaly, Ascites, Splenomeg... ORPHA:36412
Lymphangioleiomyomatosis
Gastrointestinal hemorrhage, Lymphedema, Ascites, Chylothorax, Pulmonary lymphangiomyomatosis, Ab... ORPHA:538
Congenital Enterovirus Infection
Polyhydramnios, Hydrops fetalis, Pleural effusion, Pericardial effusion, Fetal distress, Fetal as... ORPHA:292
Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Mental Retardation
Lymphedema OMIM:152950
Griscelli Syndrome
Pedal edema, Hepatomegaly, Ascites, Splenomegaly, Lymphadenopathy ORPHA:381
Buschke-Ollendorff Syndrome
Lymphedema, Hypertension ORPHA:1306
Pyruvate Kinase Deficiency Of Red Cells
Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly OMIM:266200
Campomelia, Cumming Type
Lymphedema, Hydrops fetalis, Oligohydramnios, Hepatomegaly ORPHA:1318
Tropical Endomyocardial Fibrosis
Atrial flutter, P pulmonale, Tricuspid regurgitation, Abnormal T-wave, Cardiogenic shock, Reduced... ORPHA:75565
Pseudo-Torch Syndrome 2
Hepatomegaly, Cerebral hemorrhage, Bradycardia, Ascites OMIM:617397
Carney Triad
Arrhythmia, Gastrointestinal hemorrhage, Hypertension, Tachycardia, Ascites, Mediastinal lymphade... ORPHA:139411
Lethal Congenital Contracture Syndrome 10
Hydrops fetalis, Oligohydramnios, Fetal akinesia sequence, Hypoplasia of the thymus, Overriding a... OMIM:617022
Clapo Syndrome
Lymphedema, Lymphangioma ORPHA:168984
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Splenomegaly, Portal hypertension ORPHA:131
Galactosialidosis
Hepatosplenomegaly, Cherry red spot of the macula, Nonimmune hydrops fetalis OMIM:256540
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Anasarca, Palpebral edema, Pleural effusion, Pedal edema, Hypertension, Facial edema, Pulmonary e... ORPHA:567546
Aggressive Systemic Mastocytosis
Gastrointestinal hemorrhage, Hypotension, Ascites, Hypersplenism, Portal hypertension, Hepatosple... ORPHA:98850
Cardiac Valvular Defect, Developmental
Arteria lusoria, Hydrops fetalis, Edema OMIM:212093
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Pericardial lymphangiectasia, Lymphedema, Pleural effusion, Pericardial effusion, Thyroid lymphan... OMIM:235510
Noonan Syndrome 13
Lymphedema, Mitral regurgitation OMIM:619087
Congenital Disorder Of Glycosylation, Type Ih
Hepatomegaly, Ascites, Oligohydramnios OMIM:608104
Infantile Systemic Hyalinosis
Lymphedema, Aplasia/Hypoplasia of the thymus, Telangiectasia of the skin ORPHA:2176
Eosinophilic Gastroenteritis
Edema, Ascites, Hematochezia ORPHA:2070
Dahlberg-Borer-Newcomer Syndrome
Lymphedema ORPHA:1563
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Polyhydramnios, Hydrops fetalis, Pleural effusion, Single umbilical artery, Ascites OMIM:616897
Combined Oxidative Phosphorylation Deficiency 40
Neonatal death, Premature birth, Nonimmune hydrops fetalis OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Neonatal death, Premature birth, Nonimmune hydrops fetalis OMIM:618839
Hennekam Syndrome
Hydrops fetalis, Lymphedema, Pericardial effusion, Splenomegaly, Ascites, Pulmonary lymphangiecta... ORPHA:2136
Achondrogenesis, Type Ia
Polyhydramnios, Hydrops fetalis, Stillbirth OMIM:200600
Combined Oxidative Phosphorylation Deficiency 41
Premature birth, Nonimmune hydrops fetalis OMIM:618838
Congenital Sialidosis Type 2
Hepatomegaly, Edema, Ascites, Hepatosplenomegaly, Telangiectasia, Abnormal EKG ORPHA:93400
Lymphatic Filariasis
Lymphadenitis, Lymphedema, Predominantly lower limb lymphedema, Lymphangiectasis, Abnormality of ... ORPHA:2035
Gaucher Disease Type 1
Pericardial effusion, Pedal edema, Hepatomegaly, Ascites, Hypersplenism, Splenomegaly, Pulmonary ... ORPHA:77259
Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 2
Hydrops fetalis OMIM:616738
Necrotizing Enterocolitis
Hypotension, Edema, Ascites, Shock, Bradycardia ORPHA:391673
Trisomy 1Q
Polyhydramnios, Increased nuchal translucency, Hydrops fetalis, Patent ductus arteriosus ORPHA:261344
Primary Hepatic Neuroendocrine Carcinoma
Palpitations, Right ventricular failure, Chronic noninfectious lymphadenopathy, Hepatomegaly, Hea... ORPHA:100085
Poems Syndrome
Pleural effusion, Pericardial effusion, Visceromegaly, Edema, Ascites, Pulmonary arterial hyperte... ORPHA:2905
Ovarian Fibrothecoma
Pleural effusion, Ascites ORPHA:314478
Trisomy 13
Hydrops fetalis, Patent ductus arteriosus ORPHA:3378
Pediatric Systemic Lupus Erythematosus
Pleural effusion, Pericardial effusion, Lymphadenopathy, Edema, Ascites, Raynaud phenomenon ORPHA:93552
Niemann-Pick Disease, Type A
Hepatomegaly, Ascites, Lymphadenopathy, Splenomegaly OMIM:257200
Platyspondylic Dysplasia, Torrance Type
Polyhydramnios, Hydrops fetalis ORPHA:85166
Reynolds Syndrome
Telangiectasia of the skin, Hepatomegaly, Xerostomia, Mucosal telangiectasiae, Ascites ORPHA:779
Distal Xq28 Microduplication Syndrome
Epistaxis, Upper eyelid edema, Predominantly lower limb lymphedema ORPHA:293939
Gracile Bone Dysplasia
Hypoplastic spleen, Ascites, Asplenia OMIM:602361
Diarrhea 10, Protein-Losing Enteropathy Type
Polyhydramnios, Anasarca, Hematochezia, Pleural effusion, Pericardial effusion, Ascites OMIM:618183
Ectodermal Dysplasia And Immunodeficiency 1
Lymphedema OMIM:300291
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hepatomegaly, Portal hypertension, Ascites, Splenomegaly OMIM:251880
Osteogenesis Imperfecta, Type Ii
Premature birth, Nonimmune hydrops fetalis OMIM:166210
Galactosemia
Hepatomegaly, Ascites ORPHA:352
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Lymphedema, Telangiectasia of the skin, Lip telangiectasia, Telangiectasia of the oral mucosa ORPHA:79280
Gm1 Gangliosidosis
Hydrops fetalis, Patent ductus arteriosus, Premature birth, Splenomegaly, Hepatosplenomegaly, Che... ORPHA:354
Farber Disease
Hydrops fetalis, Joint swelling, Foam cells in visceral organs and CNS, Ascites, Hepatosplenomega... ORPHA:333
Gm1-Gangliosidosis, Type I
Hydrops fetalis, Cherry red spot of the macula, Splenomegaly OMIM:230500
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Hypoplasia of the thymus, Pericardial effusion, Hypoplastic spleen, Nonimmune hydrops fetalis OMIM:619313
Classic Galactosemia
Hepatomegaly, Ascites ORPHA:79239
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Pulmonary hemorrhage, Hepatomegaly, Absence of lymph node germinal center, Ascites, Portal hypert... ORPHA:79124
Autoimmune Hepatitis
Spider hemangioma, Ascites, Gastrointestinal hemorrhage, Splenomegaly ORPHA:2137
Phelan-Mcdermid Syndrome
Lymphedema, Palpebral edema OMIM:606232
Takenouchi-Kosaki Syndrome
Lymphedema, Pulmonic stenosis OMIM:616737
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Polyhydramnios, Lymphedema, Aortic valve stenosis, Chylothorax, Mitral regurgitation OMIM:613563
Mitochondrial Trifunctional Protein Deficiency
Prenatal maternal abnormality, Hydrops fetalis, Abnormality of the amniotic fluid OMIM:609015
Fabry Disease
Conjunctival telangiectasia, Arrhythmia, Bundle branch block, Angina pectoris, Lymphedema, Mitral... ORPHA:324
Mosaic Trisomy 9
Polyhydramnios, Hydrops fetalis, Oligohydramnios, Patent ductus arteriosus, Single umbilical arte... ORPHA:99776
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Polyhydramnios, Pancreatic lymphangiectasis, Hepatomegaly, Ascites, Pulmonary lymphangiectasia, S... ORPHA:1655
Osteopetrosis, Autosomal Recessive 5
Hepatomegaly, Ascites, Splenomegaly OMIM:259720
Gaucher Disease, Perinatal Lethal
Polyhydramnios, Hepatomegaly, Nonimmune hydrops fetalis, Ascites, Splenomegaly, Hepatosplenomegaly OMIM:608013
Noonan Syndrome
Arrhythmia, Lymphedema, Abnormality of the spleen, Hepatomegaly, Abnormality of the lymphatic system ORPHA:648
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polyhydramnios, Fetal polyuria, Hydrops fetalis, Premature birth, Edema OMIM:602522
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Gastrointestinal hemorrhage, Hematemesis, Intracranial hemorrhage, Muscle hemorrhage, Hematochezi... ORPHA:464321
Cerebrofacioarticular Syndrome
Lymphedema, Pulmonic stenosis ORPHA:314679
Lymphedema-Distichiasis Syndrome
Arrhythmia, Predominantly lower limb lymphedema ORPHA:33001
Autosomal Recessive Spastic Paraplegia Type 11
Lymphedema, Orthostatic hypotension ORPHA:2822
Bannayan-Riley-Ruvalcaba Syndrome
Intracranial hemorrhage, Angina pectoris, Lymphedema, Telangiectasia ORPHA:109
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy, Ascites ORPHA:100086
Eisenmenger Syndrome
Ventricular arrhythmia, Tricuspid regurgitation, Pulmonary arterial hypertension, Syncope, Hepato... ORPHA:97214
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Hydrops fetalis, Ascites OMIM:614091
Dyssegmental Dysplasia, Silverman-Handmaker Type
Spontaneous abortion, Hydrops fetalis, Single umbilical artery, Increased placental thickness ORPHA:1865
Mucopolysaccharidosis, Type Vii
Hydrops fetalis, Splenomegaly OMIM:253220
Fibrochondrogenesis 1
Hydrops fetalis, Stillbirth OMIM:228520
Angioosteohypertrophic Syndrome
Gastrointestinal hemorrhage, Lymphedema, Telangiectasia of the skin, Pulmonary embolism, Congesti... ORPHA:2346
Adams-Oliver Syndrome
Pulmonary arterial hypertension, Portal hypertension, Ascites, Gastrointestinal hemorrhage ORPHA:974
Cardiofaciocutaneous Syndrome
Lymphedema, Pulmonic stenosis, Hypertrophic cardiomyopathy ORPHA:1340
Hereditary Elliptocytosis
Hydrops fetalis, Splenomegaly ORPHA:288
Familial Mediterranean Fever
Arrhythmia, Pericarditis, Pedal edema, Myocardial infarction, Ascites, Splenomegaly, Vasculitis, ... ORPHA:342
Fraser Syndrome 3
Hydrops fetalis OMIM:617667
Oculoectodermal Syndrome
Lymphedema, Transient ischemic attack, Hypertrophic cardiomyopathy OMIM:600268
Gm1 Gangliosidosis Type 1
Abnormal placenta morphology, Hydrops fetalis, Hepatosplenomegaly, Cherry red spot of the macula ORPHA:79255
Kanzaki Disease
Lymphedema, Lip telangiectasia, Telangiectasia of the oral mucosa OMIM:609242
Perlman Syndrome
Polyhydramnios, Edema, Visceromegaly, Ascites OMIM:267000
Acrocephalopolydactylous Dysplasia
Hepatomegaly, Polysplenia, Ascites OMIM:200995
Blomstrand Lethal Chondrodysplasia
Polyhydramnios, Hydrops fetalis, Premature birth, Coarctation of aorta ORPHA:50945
Tyrosinemia, Type I
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Splenomegaly, Hypertrophic cardiomyopathy OMIM:276700
Wolcott-Rallison Syndrome
Hepatomegaly, Dehydration, Ascites ORPHA:1667
Caroli Disease
Hepatomegaly, Portal hypertension, Ascites, Splenomegaly ORPHA:53035
S-Adenosylhomocysteine Hydrolase Deficiency
Hydrops fetalis ORPHA:88618
Atresia Of Urethra
Pulmonary insufficiency, Ascites, Oligohydramnios ORPHA:105
Greenberg Dysplasia
Polyhydramnios, Stillbirth, Pleural effusion, Neonatal death, Nonimmune hydrops fetalis, Hepatosp... OMIM:215140
Schneckenbecken Dysplasia
Polyhydramnios, Lymphedema ORPHA:3144
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polyhydramnios, Hydrops fetalis OMIM:616546
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Lymphedema, Pleural effusion, Edema, Chylothorax ORPHA:2526
Mycophenolate Mofetil Embryopathy
Hydrops fetalis, Coarctation of aorta ORPHA:268249
Grfoma
Gastrointestinal hemorrhage, Abnormal abdomen morphology, Neoplasm of the thymus, Hepatomegaly, A... ORPHA:97261
Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome
Lymphedema, Abnormality of the lymphatic system ORPHA:487796
Lysosomal Acid Lipase Deficiency
Hypovolemia, Hypotension, Dehydration, Ascites, Hypersplenism, Pulmonary arterial hypertension, H... ORPHA:275761
Functioning Gonadotropic Adenoma
Ascites ORPHA:91348
Gaucher Disease Type 3
Pericardial effusion, Hydrops fetalis, Splenomegaly ORPHA:77261
Intrahepatic Cholestasis Of Pregnancy
Ascites ORPHA:69665
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Polyhydramnios, Thickened nuchal skin fold, Misalignment of the pulmonary veins, Interrupted aort... OMIM:265380
Kasabach-Merritt Syndrome
Abnormal lymphatic vessel morphology ORPHA:2330
Primary Sclerosing Cholangitis
Spider hemangioma, Pleural effusion, Hepatomegaly, Congestive heart failure, Palmar telangiectasi... ORPHA:171
Autoimmune Lymphoproliferative Syndrome
Hydrops fetalis, Chronic noninfectious lymphadenopathy, Hypersplenism, Splenomegaly, Vasculitis, ... ORPHA:3261
Costello Syndrome
Polyhydramnios, Lymphangiectasis, Premature birth OMIM:218040
Short-Rib Thoracic Dysplasia 12
Polyhydramnios, Hepatomegaly, Edema, Ascites, Splenomegaly OMIM:269860
Ppoma
Hepatomegaly, Abnormal abdomen morphology, Ascites, Gastrointestinal hemorrhage ORPHA:97278
Peripheral Primitive Neuroectodermal Tumor
Ascites, Pelvic mass ORPHA:370348
Niemann-Pick Disease, Type C1
Hepatomegaly, Fetal ascites, Splenomegaly OMIM:257220
Primary Biliary Cholangitis
Portal hypertension, Ascites, Orthostatic hypotension ORPHA:186
Cranioectodermal Dysplasia 2
Polyhydramnios, Hydrops fetalis, Polysplenia, Patent ductus arteriosus, Splenomegaly OMIM:613610
Hepatocellular Carcinoma
Anasarca, Internal hemorrhage, Hypotension, Budd-Chiari syndrome, Pedal edema, Hepatomegaly, Asci... ORPHA:88673
Congenital Disorder Of Glycosylation, Type Ia
Pericardial effusion, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid OMIM:212065
Proteus Syndrome
Thymus hyperplasia, Lymphedema, Neoplasm of the thymus, Sudden cardiac death, Pulmonary embolism,... ORPHA:744
Generalized Arterial Calcification Of Infancy
Polyhydramnios, Abnormal retinal artery morphology, Calcification of the aorta, Hydrops fetalis, ... ORPHA:51608
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Predominantly lower limb lymphedema ORPHA:314404
Niemann-Pick Disease, Type C2
Hepatomegaly, Fetal ascites, Splenomegaly OMIM:607625
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Oligohydramnios, Hypertension, Ascites, Hypersplenism, Splenomegaly,... ORPHA:731
Somatostatinoma
Hepatomegaly, Abnormal abdomen morphology, Ascites, Gastrointestinal hemorrhage ORPHA:97283
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Dehydration, Hydrops fetalis ORPHA:79282
Mosaic Variegated Aneuploidy Syndrome
Polyhydramnios, Increased nuchal translucency, Ascites, Aortic regurgitation ORPHA:1052
Yunis-Varon Syndrome
Polyhydramnios, Tetralogy of Fallot, Hydrops fetalis, Premature birth OMIM:216340
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Polyhydramnios, Hydrops fetalis OMIM:300868
Niemann-Pick Disease Type C
Foam cells, Hydrops fetalis, Fetal ascites, Ascites, Splenomegaly, Hepatosplenomegaly ORPHA:646
Pearson Syndrome
Hydrops fetalis, Corneal stromal edema, Dehydration, Splenomegaly, Hypoplastic spleen ORPHA:699
Spondylodysplastic Ehlers-Danlos Syndrome
Lymphedema, Pulmonic stenosis, Aortic valve stenosis ORPHA:536471
Rajab Interstitial Lung Disease With Brain Calcifications 1
Portal hypertension, Ascites, Oligohydramnios OMIM:613658
Vipoma
Hepatomegaly, Abnormal abdomen morphology, Dehydration, Ascites ORPHA:97282
Noonan Syndrome 1
Lymphedema, Pulmonic stenosis, Chylothorax, Hypertrophic cardiomyopathy OMIM:163950
Glucagonoma
Hepatomegaly, Abnormal abdomen morphology, Ascites, Gastrointestinal hemorrhage ORPHA:97280
Phocomelia, Schinzel Type
Hydrops fetalis ORPHA:2879
Turner Syndrome Due To Structural X Chromosome Anomalies
Lymphedema, Myocardial infarction, Prolonged QT interval, Hypertension ORPHA:99413
Turner Syndrome
Lymphedema, Myocardial infarction, Prolonged QT interval, Hypertension ORPHA:881
Mosaic Monosomy X
Lymphedema, Myocardial infarction, Prolonged QT interval, Hypertension ORPHA:99228
Monosomy X
Lymphedema, Myocardial infarction, Prolonged QT interval, Hypertension ORPHA:99226
Hepatoerythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly ORPHA:95159
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Hydrops fetalis OMIM:263520
Monosomy 22Q13.3
Lymphedema, Palpebral edema ORPHA:48652
Gaucher Disease
Hydrops fetalis, Cherry red spot of the macula, Splenomegaly ORPHA:355
Cutis Marmorata Telangiectatica Congenita
Ascites, Telangiectasia of the skin ORPHA:1556
Aarskog Syndrome, Autosomal Dominant
Lymphedema, Hepatomegaly OMIM:100050
Yunis-Varon Syndrome
Polyhydramnios, Hydrops fetalis, Increased nuchal translucency, Tetralogy of Fallot, Renal artery... ORPHA:3472
Congenital Erythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly ORPHA:79277
D-Bifunctional Protein Deficiency
Polyhydramnios, Hepatomegaly, Fetal ascites, Splenomegaly OMIM:261515
Blackfan-Diamond Anemia
Nonimmune hydrops fetalis, Radial artery aplasia, Coarctation of aorta ORPHA:124
Pmm2-Cdg
Anasarca, Pericarditis, Angina pectoris, Intracranial hemorrhage, Lymphedema, Pericardial effusio... ORPHA:79318
Chronic Graft Versus Host Disease
Xerostomia, Pleural effusion, Ascites ORPHA:99921
Congenital Tracheal Stenosis
Polyhydramnios, Fetal ascites, Oligohydramnios ORPHA:141127
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Hydrops fetalis ORPHA:93271
Tuberous Sclerosis 1
Pulmonary lymphangiomyomatosis OMIM:191100
Tuberous Sclerosis 2
Pulmonary lymphangiomyomatosis OMIM:613254
Tuberous Sclerosis Complex
Pulmonary lymphangiomyomatosis, Aortic aneurysm ORPHA:805

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vegfc

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vegfc.

No publications found that use IMPC mice or data for Vegfc.

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MGI Allele Allele Type Produced
Vegfcem1(IMPC)Mbp Exon Deletion Mice
Vegfctm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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