Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

vascular endothelial growth factor C

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vegfc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Vegfc by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Lymphatic Malformation 4
Pedal edema, Lymphedema OMIM:615907

The table below shows human diseases predicted to be associated to Vegfc by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Nuchal Bleb, Familial
Hydrops fetalis, Stillbirth, Fetal cystic hygroma OMIM:257350
Hemolytic Disease Of Fetus And Newborn, Rh-Induced
Polyhydramnios, Hydrops fetalis, Fetal pleural effusion, Fetal ascites, Fetal pericardial effusio... OMIM:619462
Lymphatic Malformation 9
Predominantly lower limb lymphedema, Tortuous lymphatic vessels OMIM:619319
Lymphatic Malformation 11
Pedal edema, Lymphedema OMIM:619401
Gjc2-Related Late-Onset Primary Lymphedema
Pedal edema, Edema of the dorsum of hands, Predominantly lower limb lymphedema, Venous insufficie... ORPHA:568051
Lymphedema And Cerebral Arteriovenous Anomaly
Pulmonary arterial hypertension, Lymphedema OMIM:152900
Ascites, Chylous
Chylous ascites OMIM:208300
Pulmonary lymphangiomyomatosis OMIM:606690
Lymphatic Malformation 2
Lymphedema OMIM:611944
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
Lymphatic Malformation 3
Lymphedema OMIM:613480
Yellow Nail Syndrome
Predominantly lower limb lymphedema, Hypoplasia of lymphatic vessels, Lymphedema OMIM:153300
Hydrops Fetalis, Nonimmune
Hydrops fetalis, Nonimmune hydrops fetalis OMIM:236750
Lymphatic Malformation 5
Predominantly lower limb lymphedema, Hypoplasia of lymphatic vessels, Facial edema OMIM:153200
Lymphatic Malformation 1
Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Prominent superficial veins, Hypo... OMIM:153100
Lymphatic Malformation 8
Polyhydramnios, Pericardial effusion, Nonimmune hydrops fetalis, Pleural effusion, Stillbirth, Ge... OMIM:618773
Chylous Ascites
Ascites, Lymphedema ORPHA:1160
Lymphangiectasia, Pulmonary, Congenital
Polyhydramnios, Pedal edema, Pulmonary lymphangiectasia, Nonimmune hydrops fetalis, Pleural effus... OMIM:265300
Hydrops Fetalis
Polyhydramnios, Lymphedema, Pericardial effusion, Nonimmune hydrops fetalis, Abnormality of the l... ORPHA:1041
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Follicular Lymphoma
Lymphedema, Pleural effusion, Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Fetal Parvovirus Syndrome
Hypertrophic cardiomyopathy, Ascites, Hydrops fetalis, Increased nuchal translucency ORPHA:295
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
Polyhydramnios, Hydrops fetalis, Nonimmune hydrops fetalis OMIM:613124
Lymphatic Malformation 7
Pulmonary edema, Lymphedema, Pericardial effusion, Nonimmune hydrops fetalis, Pleural effusion, E... OMIM:617300
Ovarian Hyperstimulation Syndrome
Ascites OMIM:608115
Cardiomyopathy, Familial Restrictive, 6
Restrictive cardiomyopathy, Hydrops fetalis, Pulmonary insufficiency, Hepatomegaly, Ascites, Pulm... OMIM:619433
Meige Disease
Pedal edema, Lymphedema, Edema of the dorsum of hands, Predominantly lower limb lymphedema, Pleur... ORPHA:90186
Lymphatic Malformation 10
Lymphedema OMIM:619369
Congenital Pulmonary Lymphangiectasia
Pulmonary arterial hypertension, Hydrops fetalis, Pulmonic stenosis, Chylopericardium, Congestive... ORPHA:2414
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hydrops fetalis, Plantar telangiectasia, Predominantly lower limb lymphedema, Abnormality of the ... ORPHA:69735
Lymphatic Malformation 4
Pedal edema, Lymphedema OMIM:615907
Lymphatic Malformation 12
Polyhydramnios, Lymphedema, Fetal pleural effusion, Nonimmune hydrops fetalis, Fetal ascites, Fet... OMIM:620014
Chondrodysplasia, Blomstrand Type
Polyhydramnios, Hydrops fetalis, Fetal ascites, Stillbirth, Preductal coarctation of the aorta, P... OMIM:215045
Cholestasis-Lymphedema Syndrome
Splenomegaly, Hepatomegaly, Lymphedema OMIM:214900
Pericardial effusion, Ascites OMIM:256150
Dysplastic Cortical Hyperostosis
Polyhydramnios, Hydrops fetalis, Splenomegaly ORPHA:2204
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Polyhydramnios, Abnormal aortic morphology, Hydrops fetalis, Single umbilical artery ORPHA:3405
Hennekam Lymphangiectasia-Lymphedema Syndrome 2
Pulmonary lymphangiectasia, Intestinal lymphangiectasia, Pericardial lymphangiectasia, Lymphedema OMIM:616006
Cholestasis-Lymphedema Syndrome
Lymphedema, Gastrointestinal hemorrhage, Hepatomegaly, Portal hypertension, Abnormality of the ly... ORPHA:1414
Lissencephaly 2
Lymphedema OMIM:257320
Indomethacin Embryofetopathy
Hydrops fetalis, Premature birth, Oligohydramnios ORPHA:1909
Achondrogenesis, Type Ib
Polyhydramnios, Hydrops fetalis, Breech presentation, Edema, Stillbirth OMIM:600972
Lymphangiectasia, Intestinal
Pedal edema, Stillbirth, Edema, Intestinal lymphangiectasia OMIM:152800
Diffuse Neonatal Hemangiomatosis
Patent ductus arteriosus, Polyhydramnios, Hydrops fetalis, Ascites, Premature birth ORPHA:2123
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death, Hydrops fetalis OMIM:276822
Hb Bart'S Hydrops Fetalis
Polyhydramnios, Hydrops fetalis, Oligohydramnios, Preeclampsia, Splenomegaly ORPHA:163596
Developmental And Epileptic Encephalopathy 96
Hydrops fetalis OMIM:619340
Lymphatic Malformation 6
Polyhydramnios, Lymphedema, Nonimmune hydrops fetalis, Pleural effusion, Edema, Chylothorax, Peri... OMIM:616843
Alpha-Heavy Chain Disease
Splenomegaly, Ascites, Lymphadenopathy, Hepatomegaly ORPHA:100025
Fetal Gaucher Disease
Fetal akinesia sequence, Hydrops fetalis, Decreased fetal movement, Intracranial hemorrhage, Stil... ORPHA:85212
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Ascites, Hepatomegaly ORPHA:2198
Splenoportal Vascular Anomalies
Ascites, Splenomegaly OMIM:271500
Campomelia, Cumming Type
Polysplenia, Lymphedema OMIM:211890
Glycogen Storage Disease Iv
Polyhydramnios, Hydrops fetalis, Hepatosplenomegaly, Edema, Portal hypertension, Ascites, Cardiom... OMIM:232500
Dohle Bodies And Leukemia
Lymphedema OMIM:223350
Secondary Intestinal Lymphangiectasia
Lymphedema, Intestinal lymphedema, Pleural effusion, Edema, Constrictive pericarditis, Chylous as... ORPHA:90363
Alpha-N-Acetylgalactosaminidase Deficiency Type 1
Telangiectasia, Lymphedema, Hypertrophic cardiomyopathy, Hepatomegaly, Telangiectasia of the skin ORPHA:79279
Lethal Hemolytic Anemia-Genital Anomalies Syndrome
Polyhydramnios, Ascites, Splenomegaly, Oligohydramnios ORPHA:1046
Hypersplenism, Hydrops fetalis, Splenomegaly ORPHA:846
Pulmonary Edema Of Mountaineers, Susceptibility To
Elevated pulmonary artery pressure, Edema, Pulmonary edema OMIM:178400
Transaldolase Deficiency
Edema, Coarctation of aorta, Hydrops fetalis, Hepatosplenomegaly ORPHA:101028
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Ascites OMIM:174050
Primary Intestinal Lymphangiectasia
Pericardial effusion, Abnormal lymphatic vessel morphology, Pleural effusion, Edema, Ascites, Int... ORPHA:90362
Familial Atrial Myxoma
Pedal edema, Heart murmur, Congestive heart failure, Ascites, Tricuspid regurgitation ORPHA:615
Deafness-Lymphedema-Leukemia Syndrome
Lymphedema, Intracranial hemorrhage, Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:3226
Congenital Disorder Of Glycosylation, Type Ik
Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly OMIM:608540
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy, Lymphedema OMIM:607115
Hepatic Veno-Occlusive Disease
Ascites, Hepatomegaly ORPHA:890
Pseudomyxoma Peritonei
Ascites, Lymphadenopathy ORPHA:26790
Lymphedema, Primary, With Myelodysplasia
Lymphedema OMIM:614038
Lymphedema ORPHA:2485
Sialidosis Type 2
Pedal edema, Hydrops fetalis, Hepatomegaly, Ascites, Splenomegaly ORPHA:87876
Kaposi Sarcoma
Abnormality of the spleen, Generalized lymphadenopathy, Lymphedema ORPHA:33276
Infantile Sialic Acid Storage Disease
Hydrops fetalis, Congestive heart failure, Hepatomegaly, Ascites, Splenomegaly OMIM:269920
Portal Hypertension, Noncirrhotic, 2
Epistaxis, Hepatomegaly, Ascites, Portal hypertension, Splenomegaly OMIM:619463
Milroy Disease
Pedal edema, Predominantly lower limb lymphedema, Lymphedema ORPHA:79452
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Polyhydramnios, Lymphedema OMIM:618154
Idiopathic Neonatal Atrial Flutter
Hydrops fetalis, Fetal distress, Maternal diabetes ORPHA:45452
Long Qt Syndrome 3
Hydrops fetalis, Nonimmune hydrops fetalis OMIM:603830
Combined Oxidative Phosphorylation Deficiency 10
Pericardial effusion, Oligohydramnios, Pleural effusion, Hypertrophic cardiomyopathy, Ascites, Br... OMIM:614702
Greenberg Dysplasia
Lymphedema ORPHA:1426
Cardiomyopathy, Familial Hypertrophic, 4
Sudden cardiac death, Right bundle branch block, Pulmonary edema, Reduced left ventricular ejecti... OMIM:115197
Klippel-Trénaunay Syndrome
Pulmonary embolism, Hydrops fetalis, Congestive heart failure, Internal hemorrhage, Edema, Hepato... ORPHA:90308
Lymphedema, Cardiac Septal Defects, And Characteristic Facies
Oligohydramnios, Atrial flutter, Hydrops fetalis, Lymphedema OMIM:601927
Lissencephaly 7 With Cerebellar Hypoplasia
Lymphedema OMIM:616342
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death, Nonimmune hydrops fetalis OMIM:619003
Lymphedema-Hypoparathyroidism Syndrome
Pulmonary lymphangiectasia, Lymphedema OMIM:247410
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:932
Yellow Nail Syndrome
Pulmonary arterial hypertension, Hypoplasia of lymphatic vessels, Lymphedema ORPHA:662
Chromosome 1P36.33 Duplication Syndrome, Atad3 Gene Cluster, Autosomal Dominant
Fetal akinesia sequence, Hydrops fetalis OMIM:618815
Cirrhotic Cardiomyopathy
Elevated pulmonary artery pressure, Left ventricular diastolic dysfunction, Pulmonary edema, Thir... ORPHA:57777
Congenital Toxoplasmosis
Ascites, Lymphadenopathy, Hepatomegaly ORPHA:858
Kaposiform Lymphangiomatosis
Epidural hemorrhage, Pericardial effusion, Abnormal spleen morphology, Hepatosplenomegaly, Pleura... ORPHA:464329
Maternal Uniparental Disomy Of Chromosome X
Predominantly lower limb lymphedema, Congestive heart failure ORPHA:261519
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Lymphedema ORPHA:1116
Capillary Malformation-Arteriovenous Malformation
Telangiectasia, Cerebral ischemia, Lymphedema, Nonimmune hydrops fetalis, Congestive heart failur... ORPHA:137667
Klippel-Trenaunay-Weber Syndrome
Lymphangioma, Lymphedema OMIM:149000
Ovarian Hyperstimulation Syndrome
Hypovolemia, Pulmonary edema, Pleural effusion, Peripheral edema, Capillary leak, Ascites, Genera... ORPHA:64739
Neuraminidase Deficiency
Hydrops fetalis, Bone-marrow foam cells, Ascites, Splenomegaly, Cherry red spot of the macula, Fa... OMIM:256550
Mucopolysaccharidosis Type 7
Ascites, Hydrops fetalis, Splenomegaly, Lymphedema ORPHA:584
Hemochromatosis, Type 1
Telangiectasia, Congestive heart failure, Pleural effusion, Hepatomegaly, Arrhythmia, Ascites, Sp... OMIM:235200
Congenital Disorder Of Glycosylation, Type Iir
Ascites, Hepatomegaly OMIM:301045
Alpha-N-Acetylgalactosaminidase Deficiency
Lymphedema ORPHA:3137
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Polyhydramnios, Lymphedema, Thyroid lymphangiectasia, Pulmonary lymphangiectasia, Pancreatic lymp... OMIM:235255
Cronkhite-Canada Syndrome
Splenomegaly, Hepatomegaly, Lymphedema ORPHA:2930
Achondrogenesis Type 1B
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:93298
Edema, Predominantly lower limb lymphedema, Lymphangiectasis, Lymphedema ORPHA:182
Familial Exudative Vitreoretinopathy
Vitreous hemorrhage, Macular edema, Lymphedema, Retinal neovascularization, Macular telangiectasia ORPHA:891
Capillary Malformation Of The Lower Lip, Lymphatic Malformation Of Face And Neck, Asymmetry Of Face And Limbs, And Partial/Generalized Overgrowth
Lymphedema OMIM:613089
Congenital Disorder Of Glycosylation, Type Ib
Lymphangiectasis, Edema OMIM:602579
Tenosynovial Giant Cell Tumor
Joint swelling, Lymphedema ORPHA:66627
Achondrogenesis Type 1A
Polyhydramnios, Hydrops fetalis, Thickened nuchal skin fold ORPHA:93299
Malignant Peritoneal Mesothelioma
Pedal edema, Ascites ORPHA:168811
Free Sialic Acid Storage Disease
Ascites, Hydrops fetalis, Splenomegaly, Hepatomegaly ORPHA:834
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Pulmonary embolism, Edema, Hepatomegaly, Budd-Chiari syndrome, Ascites, Intestinal lymphangiectas... OMIM:226300
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Lymphedema, Pulmonary lymphangiectasia, Nonimmune hydrops fetalis, Facial telangiectasia in butte... OMIM:137940
Fabry Disease
Lymphedema, Transient ischemic attack, Congestive heart failure, Angina pectoris, Hypertension, M... OMIM:301500
Al-Gazali-Bakalinova Syndrome
Lymphedema OMIM:607131
Boomerang Dysplasia
Polyhydramnios, Hydrops fetalis ORPHA:1263
Congenital Disorder Of Glycosylation, Type Il
Pericardial effusion, Hepatosplenomegaly, Edema, Hepatomegaly, Ascites OMIM:608776
Tempi Syndrome
Transudative pleural effusion, Ascites, Telangiectasia, Intracranial hemorrhage ORPHA:284227
Lymphoproliferative Syndrome 2
Hepatosplenomegaly, Lymphadenopathy, Hepatomegaly, Ascites, Splenomegaly OMIM:615122
Hypotrichosis-Lymphedema-Telangiectasia Syndrome
Predominantly lower limb lymphedema, Palmar telangiectasia, Palpebral edema, Nonimmune hydrops fe... OMIM:607823
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Hydrops fetalis, Splenomegaly ORPHA:766
Aplasia Cutis Congenita With Intestinal Lymphangiectasia
Intestinal lymphangiectasia, Generalized edema OMIM:207731
Monosomy 18P
Hypertension, Lymphedema ORPHA:1598
German Syndrome
Lymphedema ORPHA:2077
Parkes Weber Syndrome
Vascular dilatation, Arteriovenous malformation, Cerebral arteriovenous malformation, Vascular to... ORPHA:90307
Congenital Myopathy 1B, Autosomal Recessive
Polyhydramnios, Decreased fetal movement, Hydrops fetalis OMIM:255320
Ring Chromosome 22 Syndrome
Pleural effusion, Edema, Lymphedema ORPHA:1446
Glycogen Storage Disease Of Heart, Lethal Congenital
Hypotension, Pulmonary edema, Pericardial effusion, T-wave inversion, ST segment depression, Cong... OMIM:261740
Cantu Syndrome
Pericardial effusion, Lymphedema OMIM:239850
Combined Oxidative Phosphorylation Defect Type 27
Nonimmune hydrops fetalis ORPHA:477774
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Polyhydramnios, Nonimmune hydrops fetalis, Congestive heart failure, Hepatosplenomegaly, Dilated ... ORPHA:367
Ovarian Fibroma
Pleural effusion, Ascites ORPHA:314473
Hemochromatosis, Neonatal
Nonimmune hydrops fetalis, Oligohydramnios OMIM:231100
Dengue Fever
Hypotension, Cerebral hemorrhage, Epistaxis, Hepatomegaly, Gastrointestinal hemorrhage, Ascites ORPHA:99828
Lymphedema, Chylopericardium, Abnormality of the lymphatic system, Lymphadenopathy, Chylothorax, ... ORPHA:538
Buschke-Ollendorff Syndrome
Hypertension, Lymphedema ORPHA:1306
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Lymphedema, Pericardial effusion, Thyroid lymphangiectasia, Pulmonary lymphangiectasia, Nonimmune... OMIM:235510
Wolman Disease
Ascites, Splenomegaly, Hepatomegaly ORPHA:75233
Combined Oxidative Phosphorylation Deficiency 5
Edema, Ascites, Hypertrophic cardiomyopathy OMIM:611719
Mulibrey Nanism
Ascites, Hydrops fetalis, Congestive heart failure, Hepatomegaly OMIM:253250
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Pedal edema, Pulmonary embolism, Hypertension, Pleural effusion, Edema, Palpebral edema, Anasarca... ORPHA:567546
Desmoplastic Small Round Cell Tumor
Ascites, Lymphadenopathy, Mediastinal lymphadenopathy, Hepatomegaly ORPHA:83469
Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Impaired Intellectual Development
Lymphedema OMIM:152950
Achondrogenesis, Type Ii
Polyhydramnios, Hydrops fetalis, Edema, Stillbirth OMIM:200610
Congenital Enterovirus Infection
Polyhydramnios, Hydrops fetalis, Pericardial effusion, Fetal distress, Decreased fetal movement, ... ORPHA:292
Hypocomplementemic Urticarial Vasculitis
Small vessel vasculitis, Pericardial effusion, Pleural effusion, Lymphadenopathy, Hepatomegaly, A... ORPHA:36412
Campomelia, Cumming Type
Oligohydramnios, Hydrops fetalis, Hepatomegaly, Lymphedema ORPHA:1318
Lymphedema-Distichiasis Syndrome
Lymphedema, Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Chylothorax, Arrhythmia OMIM:153400
Nonimmune hydrops fetalis, Cherry red spot of the macula, Hepatosplenomegaly OMIM:256540
Griscelli Syndrome
Pedal edema, Lymphadenopathy, Hepatomegaly, Ascites, Splenomegaly ORPHA:381
Tropical Endomyocardial Fibrosis
Pedal edema, Systolic heart murmur, Restrictive cardiomyopathy, Left ventricular diastolic dysfun... ORPHA:75565
Clapo Syndrome
Lymphangioma, Lymphedema ORPHA:168984
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Portal hypertension, Splenomegaly ORPHA:131
Noonan Syndrome 13
Mitral regurgitation, Lymphedema OMIM:619087
Dahlberg-Borer-Newcomer Syndrome
Lymphedema ORPHA:1563
Aggressive Systemic Mastocytosis
Hypotension, Hypersplenism, Hepatosplenomegaly, Lymphadenopathy, Gastrointestinal hemorrhage, Por... ORPHA:98850
Niemann-Pick Disease, Type A
Ascites, Lymphadenopathy, Splenomegaly, Hepatomegaly OMIM:257200
Cholestasis, Progressive Familial Intrahepatic, 3
Ascites, Splenomegaly, Hepatomegaly OMIM:602347
Eosinophilic Gastroenteritis
Edema, Ascites, Hematochezia ORPHA:2070
Infantile Systemic Hyalinosis
Aplasia/Hypoplasia of the thymus, Telangiectasia of the skin, Lymphedema ORPHA:2176
Carney Triad
Hypertension, Lymphadenopathy, Mediastinal lymphadenopathy, Arrhythmia, Gastrointestinal hemorrha... ORPHA:139411
Hydrops fetalis, Oligohydramnios, Edema, Ascites, Premature birth ORPHA:79325
Hennekam Syndrome
Hydrops fetalis, Lymphedema, Pericardial effusion, Pulmonary lymphangiectasia, Lymphadenopathy, C... ORPHA:2136
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Polyhydramnios, Hydrops fetalis, Pleural effusion, Ascites, Single umbilical artery OMIM:616897
Lymphatic Filariasis
Lymphadenitis, Lymphangiectasis, Lymphedema, Predominantly lower limb lymphedema, Lymphadenopathy... ORPHA:2035
Combined Oxidative Phosphorylation Deficiency 40
Nonimmune hydrops fetalis, Neonatal death, Premature birth OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Nonimmune hydrops fetalis, Neonatal death, Premature birth OMIM:618839
Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 2
Hydrops fetalis OMIM:616738
Combined Oxidative Phosphorylation Deficiency 41
Premature birth, Nonimmune hydrops fetalis OMIM:618838
Cholestasis, Progressive Familial Intrahepatic, 5
Pleural effusion, Ascites, Nonimmune hydrops fetalis OMIM:617049
Congenital Disorder Of Glycosylation, Type Ih
Edema, Ascites, Hepatomegaly, Oligohydramnios OMIM:608104
Gaucher Disease Type 1
Pulmonary arterial hypertension, Pedal edema, Pericardial effusion, Hypersplenism, Hepatomegaly, ... ORPHA:77259
Pseudo-Torch Syndrome 2
Cerebral hemorrhage, Pleural effusion, Hepatomegaly, Ascites, Bradycardia OMIM:617397
Hepatoportal Sclerosis
Hypersplenism, Gastrointestinal hemorrhage, Ascites, Portal hypertension, Splenomegaly ORPHA:64743
Trisomy 1Q
Patent ductus arteriosus, Polyhydramnios, Hydrops fetalis, Increased nuchal translucency ORPHA:261344
Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Pericarditis, Ascites, Mitral regurgitation ORPHA:2848
Distal Xq28 Microduplication Syndrome
Epistaxis, Upper eyelid edema, Predominantly lower limb lymphedema ORPHA:293939
Congenital Sialidosis Type 2
Telangiectasia, Abnormal EKG, Hepatosplenomegaly, Edema, Hepatomegaly, Ascites ORPHA:93400
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Pericardial effusion, Hypoplastic spleen, Hypoplasia of the thymus, Nonimmune hydrops fetalis OMIM:619313
Necrotizing Enterocolitis
Hypotension, Shock, Edema, Ascites, Bradycardia ORPHA:391673
Ovarian Fibrothecoma
Pleural effusion, Ascites ORPHA:314478
Poems Syndrome
Pulmonary arterial hypertension, Pericardial effusion, Pleural effusion, Edema, Lymphadenopathy, ... ORPHA:2905
Cirrhosis, Familial
Pulmonary arterial hypertension, Ascites, Hypertension OMIM:215600
Pediatric Systemic Lupus Erythematosus
Pericardial effusion, Raynaud phenomenon, Pleural effusion, Edema, Lymphadenopathy, Ascites ORPHA:93552
Trisomy 13
Patent ductus arteriosus, Hydrops fetalis ORPHA:3378
Gracile Bone Dysplasia
Hypoplastic spleen, Asplenia, Ascites OMIM:602361
Lethal Congenital Contracture Syndrome 10
Fetal akinesia sequence, Hydrops fetalis, Hypoplasia of the thymus, Oligohydramnios, Overriding a... OMIM:617022
Platyspondylic Dysplasia, Torrance Type
Polyhydramnios, Hydrops fetalis ORPHA:85166
Phakomatosis Pigmentokeratotica
Arrhythmia, Raynaud phenomenon, Lymphedema ORPHA:2874
Gaucher Disease, Perinatal Lethal
Premature birth, Polyhydramnios, Desquamation of skin soon after birth, Decreased fetal movement,... OMIM:608013
Reynolds Syndrome
Mucosal telangiectasiae, Xerostomia, Hepatomegaly, Telangiectasia of the skin, Ascites ORPHA:779
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Polyhydramnios, Lymphedema, Hepatosplenomegaly, Mitral regurgitation, Chylothorax, Aortic valve s... OMIM:613563
Primary Hepatic Neuroendocrine Carcinoma
Facial telangiectasia, Heart murmur, Right ventricular failure, Palpitations, Hepatomegaly, Chron... ORPHA:100085
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Telangiectasia of the skin, Lip telangiectasia, Telangiectasia of the oral mucosa, Lymphedema ORPHA:79280
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Retinal hemorrhage, Vitreous hemorrhage, Cerebral hemorrhage, Intracranial hemorrhage, Diffuse al... ORPHA:464321
Gm1 Gangliosidosis
Patent ductus arteriosus, Premature birth, Hydrops fetalis, Hepatosplenomegaly, Splenomegaly, Che... ORPHA:354
Takenouchi-Kosaki Syndrome
Pulmonic stenosis, Lymphedema OMIM:616737
Aicardi-Goutieres Syndrome 9
Pericardial effusion, Hypertension, Hepatosplenomegaly, Pericarditis, Edema, Increased blood pres... OMIM:619487
Ascites, Hepatomegaly ORPHA:352
Farber Disease
Hydrops fetalis, CNS foam cells, Hepatosplenomegaly, Lymphadenopathy, Joint swelling, Ascites, Ch... ORPHA:333
Bannayan-Riley-Ruvalcaba Syndrome
Telangiectasia, Intracranial hemorrhage, Angina pectoris, Lymphedema ORPHA:109
Phelan-Mcdermid Syndrome
Palpebral edema, Lymphedema OMIM:606232
Fabry Disease
Mucosal telangiectasiae, Lymphedema, Transient ischemic attack, Bundle branch block, Telangiectas... ORPHA:324
Achondrogenesis, Type Ia
Polyhydramnios, Hydrops fetalis, Stillbirth, Increased nuchal translucency, Absence of stomach bu... OMIM:200600
Sclerosing Cholangitis, Neonatal
Portal hypertension, Ascites, Splenomegaly, Hepatomegaly OMIM:617394
Diarrhea 10, Protein-Losing Enteropathy Type
Polyhydramnios, Pericardial effusion, Pleural effusion, Anasarca, Ascites, Hematochezia OMIM:618183
Classic Galactosemia
Ascites, Hepatomegaly ORPHA:79239
Ectodermal Dysplasia And Immunodeficiency 1
Lymphedema OMIM:300291
Fraser Syndrome 3
Sonographic non-visualized fetal bladder, Nonimmune hydrops fetalis, Oligohydramnios, Stillbirth,... OMIM:617667
Gm1-Gangliosidosis, Type I
Hydrops fetalis, Splenomegaly, Cherry red spot of the macula OMIM:230500
Cerebrofacioarticular Syndrome
Pulmonic stenosis, Lymphedema ORPHA:314679
Schneckenbecken Dysplasia
Polyhydramnios, Nonimmune hydrops fetalis, Stillbirth OMIM:269250
Mitochondrial Trifunctional Protein Deficiency 1
Prenatal maternal abnormality, Abnormality of the amniotic fluid, Hydrops fetalis OMIM:609015
Noonan Syndrome
Lymphedema, Abnormality of the lymphatic system, Hepatomegaly, Arrhythmia, Abnormality of the spleen ORPHA:648
Pyruvate Kinase Deficiency Of Red Cells
Nonimmune hydrops fetalis, Splenomegaly OMIM:266200
Mosaic Trisomy 9
Patent ductus arteriosus, Asplenia, Polyhydramnios, Hydrops fetalis, Oligohydramnios, Single umbi... ORPHA:99776
Autosomal Recessive Spastic Paraplegia Type 11
Orthostatic hypotension, Lymphedema ORPHA:2822
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Pulmonary hemorrhage, Hepatosplenomegaly, Hepatomegaly, Portal hypertension, Absence of lymph nod... ORPHA:79124
Eisenmenger Syndrome
Pedal edema, Ventricular arrhythmia, Supraventricular arrhythmia, Angina pectoris, Palpitations, ... ORPHA:97214
Cardiofaciocutaneous Syndrome
Hypertrophic cardiomyopathy, Pulmonic stenosis, Lymphedema ORPHA:1340
Autoimmune Hepatitis
Spider hemangioma, Ascites, Splenomegaly, Gastrointestinal hemorrhage ORPHA:2137
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Arrhythmia ORPHA:33001
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Polyhydramnios, Pulmonary lymphangiectasia, Hepatosplenomegaly, Pancreatic lymphangiectasis, Hepa... ORPHA:1655
Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development
Nonimmune hydrops fetalis OMIM:618265
Anemia, Congenital Dyserythropoietic, Type Ia
Hydrops fetalis, Splenomegaly OMIM:224120
Dyssegmental Dysplasia, Silverman-Handmaker Type
Single umbilical artery, Increased placental thickness, Hydrops fetalis ORPHA:1865
Greenberg Dysplasia
Polyhydramnios, Hydrops fetalis, Neonatal death, Nonimmune hydrops fetalis, Hepatosplenomegaly, E... OMIM:215140
Immunodeficiency 22
Pericarditis, Ascites, Capillary leak OMIM:615758
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Patent ductus arteriosus, Asplenia, Polyhydramnios, Thickened nuchal skin fold, Neonatal death, I... OMIM:265380
Angioosteohypertrophic Syndrome
Pulmonary embolism, Lymphedema, Congestive heart failure, Gastrointestinal hemorrhage, Telangiect... ORPHA:2346
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Ascites, Hydrops fetalis OMIM:614091
Osteogenesis Imperfecta, Type Ii
Premature birth, Nonimmune hydrops fetalis OMIM:166210
Cardiomyopathy, Familial Hypertrophic, 27
Nonimmune hydrops fetalis OMIM:618052
Familial Mediterranean Fever
Pedal edema, Pericarditis, Myocardial infarction, Lymphadenopathy, Arrhythmia, Ascites, Splenomeg... ORPHA:342
Fibrochondrogenesis 1
Hydrops fetalis, Stillbirth OMIM:228520
Crimean-Congo Hemorrhagic Fever
Hypotension, Hemoperitoneum, Pericardial effusion, Abnormal left ventricular function, Subdural h... ORPHA:99827
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy, Ascites ORPHA:100086
Adams-Oliver Syndrome
Portal hypertension, Ascites, Gastrointestinal hemorrhage, Pulmonary arterial hypertension ORPHA:974
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Portal hypertension, Ascites, Splenomegaly, Hepatomegaly OMIM:251880
Gm1 Gangliosidosis Type 1
Abnormal placenta morphology, Hydrops fetalis, Cherry red spot of the macula, Hepatosplenomegaly ORPHA:79255
Kasabach-Merritt Syndrome
Abnormal lymphatic vessel morphology ORPHA:2330
Hereditary Elliptocytosis
Hydrops fetalis, Splenomegaly ORPHA:288
S-Adenosylhomocysteine Hydrolase Deficiency
Hydrops fetalis ORPHA:88618
Mucopolysaccharidosis, Type Vii
Hydrops fetalis, Splenomegaly OMIM:253220
Kanzaki Disease
Telangiectasia of the oral mucosa, Lacunar stroke, Lip telangiectasia, Lymphedema OMIM:609242
Oculoectodermal Syndrome
Transient ischemic attack, Hypertrophic cardiomyopathy, Lymphedema OMIM:600268
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Predominantly lower limb lymphedema OMIM:604121
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Pleural effusion, Lymphadenopathy, Hepatomegaly, Ascites, Splenomegaly OMIM:306400
Ogden Syndrome
Pulmonary arterial hypertension, Torsade de pointes, Supraventricular tachycardia, Pulmonary edem... OMIM:300855
Wolcott-Rallison Syndrome
Ascites, Hepatomegaly, Dehydration ORPHA:1667
Anemia, Congenital Dyserythropoietic, Type Iv
Hydrops fetalis, Splenomegaly, Hepatosplenomegaly OMIM:613673
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Pleural effusion, Edema, Chylothorax, Lymphedema ORPHA:2526
Spondylodysplastic Ehlers-Danlos Syndrome
Aortic valve stenosis, Pulmonic stenosis, Lymphedema ORPHA:536471
Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome
Abnormality of the lymphatic system, Lymphedema ORPHA:487796
Immunodeficiency 87 And Autoimmunity
Pulmonary arterial hypertension, Third degree atrioventricular block, Hypertension, Dilated cardi... OMIM:619573
Acrocephalopolydactylous Dysplasia
Ascites, Polysplenia, Hepatomegaly OMIM:200995
Congenital Disorder Of Glycosylation, Type Ia
Pericardial effusion, Nonimmune hydrops fetalis, Edema, Stroke-like episode, Abnormality of the a... OMIM:212065
Blomstrand Lethal Chondrodysplasia
Polyhydramnios, Hydrops fetalis, Premature birth, Coarctation of aorta ORPHA:50945
Hydrops fetalis, Pericardial effusion, Decreased fetal movement, Oligohydramnios, Abnormal renal ... ORPHA:79328
Patent ductus arteriosus, Hydrops fetalis ORPHA:79329
Atresia Of Urethra
Ascites, Pulmonary insufficiency, Oligohydramnios ORPHA:105
Perlman Syndrome
Polyhydramnios, Ascites, Edema, Visceromegaly OMIM:267000
Schneckenbecken Dysplasia
Polyhydramnios, Lymphedema ORPHA:3144
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polyhydramnios, Hydrops fetalis, Edema, Fetal polyuria, Premature birth OMIM:602522
Lysosomal Acid Lipase Deficiency
Hypotension, Pulmonary arterial hypertension, Hypovolemia, Hypersplenism, Hepatosplenomegaly, Deh... ORPHA:275761
Hepatocellular Carcinoma
Hypotension, Pedal edema, Internal hemorrhage, Hepatomegaly, Portal hypertension, Anasarca, Ascit... ORPHA:88673
Mycophenolate Mofetil Embryopathy
Hydrops fetalis, Coarctation of aorta ORPHA:268249
Spondyloocular Syndrome
Lymphedema OMIM:605822
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polyhydramnios, Hydrops fetalis OMIM:616546
Tyrosinemia, Type I
Hypertrophic cardiomyopathy, Hepatomegaly, Gastrointestinal hemorrhage, Ascites, Splenomegaly, Me... OMIM:276700
Caroli Disease
Portal hypertension, Ascites, Splenomegaly, Hepatomegaly ORPHA:53035
Short-Rib Thoracic Dysplasia 12
Polyhydramnios, Edema, Hepatomegaly, Ascites, Splenomegaly OMIM:269860
Peripheral Primitive Neuroectodermal Tumor
Ascites, Pelvic mass ORPHA:370348
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Stroke, Subdural hemorrhage, Hydrops fetalis, Dehydration ORPHA:79282
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Patent ductus arteriosus, Polyhydramnios, Hydrops fetalis, Fetal distress, Breech presentation, B... OMIM:300868
Xfe Progeroid Syndrome
Ascites, Hypertension OMIM:610965
Costello Syndrome
Lymphangiectasis, Premature birth, Polyhydramnios OMIM:218040
Functioning Gonadotropic Adenoma
Ascites ORPHA:91348
Osteopetrosis, Autosomal Recessive 5
Ascites, Splenomegaly, Hepatomegaly, Hepatosplenomegaly OMIM:259720
Autoimmune Lymphoproliferative Syndrome
Hydrops fetalis, Hypersplenism, Lymphadenopathy, Chronic noninfectious lymphadenopathy, Splenomeg... ORPHA:3261
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Polyhydramnios, Ascites, Congestive heart failure OMIM:617156
Neoplasm of the thymus, Abnormal abdomen morphology, Gastrointestinal hemorrhage, Hepatomegaly, A... ORPHA:97261
Intrahepatic Cholestasis Of Pregnancy
Ascites ORPHA:69665
Gaucher Disease Type 3
Pericardial effusion, Hydrops fetalis, Splenomegaly ORPHA:77261
Generalized Arterial Calcification Of Infancy
Polyhydramnios, Hydrops fetalis, Arterial calcification, Abnormal retinal artery morphology, Tran... ORPHA:51608
Senior-Boichis Syndrome
Portal hypertension, Ascites, Hypertension, Hepatosplenomegaly ORPHA:84081
Cardiac Valvular Dysplasia 1
Left aortic arch with cervical origin of the right subclavian artery, Hydrops fetalis, Edema, Pul... OMIM:212093
Proteus Syndrome
Sudden cardiac death, Pulmonary embolism, Neoplasm of the thymus, Lymphedema, Thymus hyperplasia,... ORPHA:744
Mitchell-Riley Syndrome
Ascites OMIM:615710
Multiple Pterygium Syndrome, Escobar Variant
Decreased fetal movement, Hydrops fetalis OMIM:265000
Primary Sclerosing Cholangitis
Spider hemangioma, Congestive heart failure, Hepatosplenomegaly, Pleural effusion, Hepatomegaly, ... ORPHA:171
Fetal Akinesia Deformation Sequence 1
Polyhydramnios, Fetal akinesia sequence, Short umbilical cord, Decreased fetal movement, Nonimmun... OMIM:208150
Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites, Hepatomegaly ORPHA:97278
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Predominantly lower limb lymphedema ORPHA:314404
Primary Biliary Cholangitis
Portal hypertension, Orthostatic hypotension, Ascites ORPHA:186
Wilson Disease
Pedal edema, Edema, Hepatomegaly, Ascites, Splenomegaly OMIM:277900
Cranioectodermal Dysplasia 2
Patent ductus arteriosus, Polyhydramnios, Hydrops fetalis, Polysplenia, Splenomegaly OMIM:613610
Cutis Laxa, Autosomal Recessive, Type Ic
Ascites, Hypoplasia of the thymus, Accessory spleen, Periorbital edema OMIM:613177
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Ascites, Splenomegaly, Hepatomegaly OMIM:301072
Abnormal abdomen morphology, Hepatomegaly, Dehydration, Ascites, Hematochezia ORPHA:97282
Noonan Syndrome 1
Hypertrophic cardiomyopathy, Pulmonic stenosis, Chylothorax, Lymphedema OMIM:163950
Pearson Syndrome
Hydrops fetalis, Corneal stromal edema, Dehydration, Hypoplastic spleen, Splenomegaly ORPHA:699
Niemann-Pick Disease Type C
Hydrops fetalis, Hepatosplenomegaly, Fetal ascites, Bone-marrow foam cells, Ascites, Foam cells, ... ORPHA:646
Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites, Hepatomegaly ORPHA:97283
Autosomal Recessive Polycystic Kidney Disease
Hypersplenism, Hypertension, Hepatosplenomegaly, Oligohydramnios, Gastrointestinal hemorrhage, Po... ORPHA:731
Pearson Marrow-Pancreas Syndrome
Hydrops fetalis, Dehydration OMIM:557000
Mosaic Variegated Aneuploidy Syndrome
Aortic regurgitation, Polyhydramnios, Ascites, Increased nuchal translucency ORPHA:1052
Turner Syndrome Due To Structural X Chromosome Anomalies
Myocardial infarction, Prolonged QT interval, Hypertension, Lymphedema ORPHA:99413
Turner Syndrome
Myocardial infarction, Prolonged QT interval, Hypertension, Lymphedema ORPHA:881
Mosaic Monosomy X
Myocardial infarction, Prolonged QT interval, Hypertension, Lymphedema ORPHA:99228
Monosomy X
Myocardial infarction, Prolonged QT interval, Hypertension, Lymphedema ORPHA:99226
Monosomy 22Q13.3
Palpebral edema, Lymphedema ORPHA:48652
Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites, Hepatomegaly ORPHA:97280
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Hydrops fetalis OMIM:263520
Hepatoerythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly ORPHA:95159
Phocomelia, Schinzel Type
Hydrops fetalis ORPHA:2879
Cutis Marmorata Telangiectatica Congenita
Ascites, Telangiectasia of the skin ORPHA:1556
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Anasarca, Ascites, Hepatomegaly OMIM:203700
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Ascites, Hepatomegaly OMIM:256810
Yunis-Varon Syndrome
Polyhydramnios, Hydrops fetalis, Tetralogy of Fallot, Renal artery stenosis, Increased nuchal tra... ORPHA:3472
Gaucher Disease
Hydrops fetalis, Splenomegaly, Cherry red spot of the macula ORPHA:355
Rajab Interstitial Lung Disease With Brain Calcifications 1
Anasarca, Ascites, Portal hypertension, Oligohydramnios OMIM:613658
Biliary, Renal, Neurologic, And Skeletal Syndrome
Pulmonary arterial hypertension, Polyhydramnios, Bidirectional shunt, Tricuspid regurgitation, Le... OMIM:619534
Congenital Erythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid, Splenomegaly ORPHA:79277
Blackfan-Diamond Anemia
Radial artery aplasia, Nonimmune hydrops fetalis, Coarctation of aorta ORPHA:124
Liver Disease, Severe Congenital
Systolic heart murmur, Pulmonary edema, Abnormal left ventricular function, Hepatomegaly, Ascites... OMIM:619991
Lymphedema, Pericardial effusion, Angina pectoris, Intracranial hemorrhage, Pericarditis, Hypertr... ORPHA:79318
Chronic Graft Versus Host Disease
Pleural effusion, Ascites, Xerostomia ORPHA:99921
Yunis-Varon Syndrome
Polyhydramnios, Tetralogy of Fallot, Premature birth, Hydrops fetalis OMIM:216340
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Hydrops fetalis ORPHA:93271
Tuberous Sclerosis 1
Pulmonary lymphangiomyomatosis OMIM:191100
Tuberous Sclerosis 2
Pulmonary lymphangiomyomatosis OMIM:613254
Tuberous Sclerosis Complex
Aortic aneurysm, Pulmonary lymphangiomyomatosis ORPHA:805


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vegfc

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vegfc.

No publications found that use IMPC mice or data for Vegfc.

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MGI Allele Allele Type Produced
Vegfctm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Vegfcem1(IMPC)Mbp Exon Deletion Mice
Vegfctm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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