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Gene: Meis2 MGI:108564

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Meis homeobox 2
Synonyms:
Stra10,  Meis2,  A430109D20Rik,  Mrg1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Meis2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Meis2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cleft Palate, Cardiac Defects, And Impaired Intellectual Development
Laterally extended eyebrow, Ventricular septal defect, Short stature, Highly arched eyebrow, Secu... OMIM:600987
15Q14 Microdeletion Syndrome
Atrial septal defect, Ventricular septal defect, Short stature ORPHA:261190

The table below shows human diseases predicted to be associated to Meis2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Marcus-Gunn Syndrome
Postnatal growth retardation, Unilateral ptosis, Abnormal fifth cranial nerve morphology, Abnorma... ORPHA:91412
Neurotrophic Keratopathy
Abnormal fifth cranial nerve morphology, Corneal scarring, Corneal stromal edema, Astigmatism, Re... ORPHA:137596
Chromosome 22Q11.2 Deletion Syndrome, Distal
Intrauterine growth retardation, Truncus arteriosus, Short stature, Highly arched eyebrow OMIM:611867
Schwannomatosis 1
Vestibular schwannoma, Peripheral schwannoma OMIM:162091
Renal-Hepatic-Pancreatic Dysplasia 2
Hepatomegaly, Malformation of the hepatic ductal plate, Asplenia, Situs inversus totalis, Cholest... OMIM:615415
Igg4-Related Ophthalmic Disease
Palpebral edema, Cholangitis, Abnormal fifth cranial nerve morphology, Abnormality of infra-orbit... ORPHA:449563
Deafness, Autosomal Dominant 9
Abnormality of the vestibulocochlear nerve OMIM:601369
Microcephaly-Cardiac Defect-Lung Malsegmentation Syndrome
Ventricular septal defect, Abnormal aortic morphology, Blepharophimosis, Intrauterine growth reta... ORPHA:2516
Congenital Heart Defects, Multiple Types, 9
Mitral atresia, Aortopulmonary collateral arteries, Arteria lusoria, Double outlet right ventricl... OMIM:620294
Verheij Syndrome
Branchial cyst, Ventricular septal defect, Optic nerve hypoplasia, Short stature, Growth delay, I... OMIM:615583
Adams-Oliver Syndrome 6
Tricuspid regurgitation, Ventricular septal defect, Portal hypertension, Splenomegaly, Hepatic fi... OMIM:616589
Burning Mouth Syndrome
Abnormal fifth cranial nerve morphology, Abnormality of somatosensory evoked potentials ORPHA:353253
Scimitar Syndrome
Heart block, Pulmonary artery hypoplasia, Atrial septal defect, Single ventricle, Patent ductus a... ORPHA:185
Microphthalmia, Syndromic 9
Severe short stature, Truncus arteriosus, Ventricular septal defect, Short stature, Blepharophimo... OMIM:601186
14Q24.1Q24.3 Microdeletion Syndrome
Ventricular septal defect, Synophrys, Abnormal heart morphology, Atrial septal defect, Truncus ar... ORPHA:401935
Double Outlet Right Ventricle
Tachycardia, Ventricular septal defect, Short stature, Double outlet right ventricle, Heart murmu... ORPHA:3426
Hereditary Motor And Sensory Neuropathy, Okinawa Type
Abnormal peripheral action potential amplitude, Abnormality of the seventh cranial nerve ORPHA:90117
Aortic Arch Interruption
Bicuspid aortic valve, Aortic valve atresia, Aortopulmonary window, Absent pulse, Single ventricl... ORPHA:2299
Emanuel Syndrome
Truncus arteriosus, Ventricular septal defect, Patent ductus arteriosus, Upslanted palpebral fiss... OMIM:609029
Emanuel Syndrome
Truncus arteriosus, Ventricular septal defect, Hooded eyelid, Patent ductus arteriosus, Growth de... ORPHA:96170
Stankiewicz-Isidor Syndrome
Patent ductus arteriosus, Truncus arteriosus, Abnormal optic disc morphology, Ventricular septal ... OMIM:617516
Truncus Arteriosus
Abnormal coronary artery morphology, Anomalous origin of one pulmonary artery from ascending aort... ORPHA:3384
Superficial Siderosis
Subarachnoid hemorrhage, Abnormality of the vestibulocochlear nerve, Anisocoria, Abnormality of t... ORPHA:247245
Arnold-Chiari Malformation Type I
Myelopathy, Cranial nerve compression, Abnormality of the vestibulocochlear nerve, Abnormality of... ORPHA:268882
Charcot-Marie-Tooth Disease, Recessive Intermediate B
Decreased compound muscle action potential amplitude, Vestibular schwannoma OMIM:613641
Hemoglobin D Disease
Increased HbA2 hemoglobin, Decreased mean corpuscular hemoglobin concentration, HbS hemoglobin, A... ORPHA:90039
Absence Of The Pulmonary Artery
Abnormal coronary artery morphology, Cardiomegaly, Atrial septal defect, Patent foramen ovale, Ab... ORPHA:980
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Hydranencephaly, Truncus arteriosus, Ventricular septal defect OMIM:601355
Conotruncal Heart Malformations
Complete atrioventricular canal defect, Double outlet right ventricle, Coarctation of aorta, Tran... OMIM:217095
Cleft-Limb-Heart Malformation Syndrome
Truncus arteriosus OMIM:215850
22Q11.2 Deletion Syndrome
Abnormal eyelid morphology, Abnormal aortic arch morphology, Hypoplasia of the thymus, Atrial sep... ORPHA:567
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Aortic regurgitation, Unilateral ptosis, Bicuspid aortic valve, Truncus arteriosus, Ventricular s... ORPHA:508498
Heart Defects, Congenital, And Other Congenital Anomalies
Absent gallbladder, Hypoplastic tricuspid valve, Double outlet left ventricle, Ventricular septal... OMIM:600001
Congenital Rubella Syndrome
Hepatomegaly, Cataract, Corneal opacity, Ventricular septal defect, Short stature, Splenomegaly, ... ORPHA:290
Acrocardiofacial Syndrome
Ventricular septal defect, Mitral stenosis, Coarctation of aorta, Long eyelashes, Atrial septal d... ORPHA:2008
Hemochromatosis, Type 2B
Elevated hepatic transaminase, Hepatomegaly, Splenomegaly, Congestive heart failure, Cardiomyopat... OMIM:613313
Attrv122I Amyloidosis
Abnormal EKG, Angina pectoris, Abnormal atrioventricular conduction, Abnormal enteric nervous sys... ORPHA:85451
Ring Dermoid Of Cornea
Corneal astigmatism, Abnormal corneal limbus morphology, Abnormal cornea morphology, Abnormal con... OMIM:180550
Anemia, Congenital Dyserythropoietic, Type Ib
Hepatomegaly, Reticulocytosis, Short stature, Anemia of inadequate production, Anisocytosis, Sple... OMIM:615631
Transaldolase Deficiency
Hepatomegaly, Pancytopenia, Ventricular septal defect, Splenomegaly, Micronodular cirrhosis, Pate... OMIM:606003
Structural Heart Defects And Renal Anomalies Syndrome
Ventricular septal defect, Partial anomalous pulmonary venous return, Right aortic arch, Persiste... OMIM:617478
Osteopetrosis, Autosomal Recessive 4
Hepatomegaly, Optic disc pallor, Reticulocytosis, Facial palsy, Splenomegaly, Optic atrophy, Grow... OMIM:611490
8Q24.3 Microdeletion Syndrome
Branchial cyst, Atrioventricular canal defect, Spina bifida occulta, Dysplastic aortic valve, Sho... ORPHA:508488
Distal 22Q11.2 Microdeletion Syndrome
Aortic regurgitation, Branchial fistula, Ventricular septal defect, Short stature, Highly arched ... ORPHA:261330
Leprosy
Absent eyebrow, Epistaxis, Abnormality of the spleen, Abnormality of the seventh cranial nerve, L... ORPHA:548
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Sideroblastic anemia, Overriding aorta, Ventricular septal defect, Extramedullary hematopoiesis, ... OMIM:617021
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Hepatomegaly, Splenomegaly, Thrombocytopenia, Optic atrophy, Cardiomyopathy, Stroke, Neutropenia,... ORPHA:79312
Osteopetrosis, Autosomal Recessive 8
Hepatomegaly, Facial palsy, Splenomegaly, Thrombocytopenia, Optic atrophy, Anemia OMIM:615085
Gillespie Syndrome
Hypoplasia of the iris, Truncus arteriosus, Aniridia OMIM:206700
Hemochromatosis, Type 4
Hepatomegaly, Cataract, Cardiomyopathy, Cirrhosis, Arrhythmia, Hepatic steatosis, Anemia OMIM:606069
Neonatal Lupus Erythematosus
Elevated hepatic transaminase, Hepatomegaly, Prolonged QT interval, Hemolytic anemia, Aplastic an... ORPHA:398124
Vitamin B12-Unresponsive Methylmalonic Acidemia
Hepatomegaly, Macrocytic anemia, Thrombocytopenia, Optic atrophy, Leukopenia, Cardiomyopathy, Pan... ORPHA:27
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death, Cataract, Anemia, Hepatosplenomegaly OMIM:273680
Cholesteryl Ester Storage Disease
Acute hepatic failure, Bone-marrow foam cells, Leukopenia, Hepatic fibrosis, Elevated gamma-gluta... OMIM:278000
Anemia, Congenital Dyserythropoietic, Type Iv
Hepatomegaly, Decreased hemoglobin concentration, Circulating nucleated red blood cells, Short st... OMIM:613673
Anemia, Sideroblastic, 3, Pyridoxine-Refractory
Elevated hepatic transaminase, Hepatomegaly, Anisocytosis, Splenomegaly, Jaundice, Hepatosplenome... OMIM:616860
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Hepatomegaly, Thrombocytopenia, Optic atrophy, Growth delay, Neutropenia, Pancreatitis, Anemia ORPHA:289916
Digeorge Syndrome
Ventricular septal defect, Short stature, Sclerocornea, Splenomegaly, Patent ductus arteriosus, T... OMIM:188400
Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb
Aortic regurgitation, Epicanthus, Cataract, Bicuspid aortic valve, Sutural cataract, Highly arche... OMIM:612474
Cyanosis, Transient Neonatal
Hepatomegaly, Reticulocytosis, Jaundice, Methemoglobinemia, Anemia OMIM:613977
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Reticulocytosis, Anisocytosis, Reduced red cell pyruvate kinase level, Splenomegaly, Abnormal ery... ORPHA:766
Al Amyloidosis
Gastrointestinal hemorrhage, Hepatomegaly, Abnormal EKG, Howell-Jolly bodies, Abnormal cardiac ve... ORPHA:85443
Fanconi Anemia, Complementation Group T
Acute myeloid leukemia, Pancytopenia, Short stature, Facial palsy, Anemia, Thrombocytopenia OMIM:616435
Beta-Thalassemia
Hepatomegaly, Abnormal hemoglobin, Microcytic anemia, Splenomegaly, Thrombocytopenia, Hepatitis, ... ORPHA:848
Alpha-Thalassemia
Hemolytic anemia, Abnormal hemoglobin, Microcytic anemia, Hypersplenism, Splenomegaly, Jaundice, ... ORPHA:846
Fabry Disease
Angina pectoris, Corneal dystrophy, Myocardial infarction, Transient ischemic attack, Congestive ... OMIM:301500
Peripartum Cardiomyopathy
Ventricular tachycardia, Left bundle branch block, Right ventricular dilatation, Abnormal T-wave,... ORPHA:563
Hepatoportal Sclerosis
Elevated hepatic transaminase, Gastrointestinal hemorrhage, Portal hypertension, Nodular regenera... ORPHA:64743
Tangier Disease
Accelerated atherosclerosis, Peripheral axonal neuropathy, Corneal opacity, Carotid artery stenos... ORPHA:31150
Anemia, Congenital Dyserythropoietic, Type Ia
Hepatomegaly, Hemolytic anemia, Reticulocytosis, Mild postnatal growth retardation, Reduced level... OMIM:224120
Dehydrated Hereditary Stomatocytosis
Hemolytic anemia, Reticulocytosis, Increased circulating lactate dehydrogenase concentration, Mac... ORPHA:3202
Microgastria-Limb Reduction Defect Syndrome
Hepatomegaly, Abnormality of the spleen, Growth delay, Atrial septal defect, Truncus arteriosus ORPHA:2538
Glycogen Storage Disease Xii
Normocytic anemia, Hepatomegaly, Epicanthus, Increased circulating lactate dehydrogenase concentr... OMIM:611881
Osteopetrosis, Autosomal Recessive 2
Pancytopenia, Extramedullary hematopoiesis, Thrombocytopenia, Cranial nerve compression, Optic at... OMIM:259710
Anemia, Hypochromic Microcytic, With Iron Overload 2
Hepatomegaly, Splenomegaly, Growth delay, Decreased mean corpuscular volume, Poikilocytosis, Elev... OMIM:615234
Combined Oxidative Phosphorylation Deficiency 42
Cardiomyopathy, Decreased liver function, Neonatal death, Intrauterine growth retardation, Anemia OMIM:618839
Hb Bart'S Hydrops Fetalis
Hepatomegaly, Pericarditis, Abnormal hemoglobin, Splenomegaly, Congestive heart failure, Anemia ORPHA:163596
Combined Oxidative Phosphorylation Deficiency 40
Decreased liver function, Neonatal death, Intrauterine growth retardation, Hypertrophic cardiomyo... OMIM:618835
Lattice Corneal Dystrophy Type I
Subepithelial corneal opacities, Corneal opacity, Central opacification of the cornea, Corneal sc... ORPHA:98964
Hereditary Spherocytosis
Hepatomegaly, Reticulocytosis, Extramedullary hematopoiesis, Spontaneous hemolytic crises, Restri... ORPHA:822
Sitosterolemia 1
Reticulocytosis, Carotid artery stenosis, Splenomegaly, Thrombocytopenia, Giant platelets, Xanthe... OMIM:210250
Benign Schwannoma
Facial palsy, Schwannoma, Peripheral schwannoma, Abnormality of the twelfth cranial nerve, Sclera... ORPHA:252164
Abnormal Origin Of Right Or Left Pulmonary Artery From The Aorta
Left-to-right shunt, Ventricular septal defect, Congestive heart failure, Patent ductus arteriosu... ORPHA:99050
Gaucher Disease, Type I
Hepatomegaly, Pancytopenia, Epistaxis, Hypersplenism, Splenomegaly, Thrombocytopenia, Hypertensio... OMIM:230800
Eisenmenger Syndrome
Ventricular tachycardia, Aortopulmonary window, Iron deficiency anemia, Abnormality of the liver,... ORPHA:97214
Congenital Dyserythropoietic Anemia Type Iii
Elevated hepatic transaminase, Short stature, Anisocytosis, Abnormal erythrocyte morphology, Mele... ORPHA:98870
Primordial Dwarfism-Immunodeficiency-Lipodystrophy Syndrome
Accessory spleen, Elevated hepatic transaminase, Cataract, Severe B lymphocytopenia, Portal hyper... OMIM:620005
Full Schwannomatosis
Schwannoma, Cataract, Peripheral schwannoma, Bilateral vestibular schwannoma ORPHA:93921
Femoral-Facial Syndrome
Short stature, Ventricular septal defect, Upslanted palpebral fissure, Pulmonic stenosis, Truncus... OMIM:134780
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Papilledema, Mitral valve calcification, Spontaneous, recurrent epistaxis, Corneal opacity, Pancy... ORPHA:2072
Neurofibromatosis, Type Iii, Mixed Central And Peripheral
Palmar neurofibroma, Paraspinal neurofibroma, Bilateral vestibular schwannoma, Lisch nodules OMIM:162260
Schwannomatosis, Vestibular
Bilateral vestibular schwannoma, Retinal hamartoma, Peripheral schwannoma, Occasional neurofibrom... OMIM:101000
Telangiectasia, Hereditary Hemorrhagic, Type 1
Conjunctival telangiectasia, Cerebral arteriovenous malformation, Tongue telangiectasia, Venous v... OMIM:187300
Legius Syndrome
Cataract, Short stature, Acute monocytic leukemia, Paroxysmal atrial tachycardia, Neurofibroma, M... ORPHA:137605
Telangiectasia, Hereditary Hemorrhagic, Type 2
Conjunctival telangiectasia, Cerebral arteriovenous malformation, Tongue telangiectasia, Spinal a... OMIM:600376
Osteopetrosis, Autosomal Recessive 3
Extramedullary hematopoiesis, Short stature, Hepatosplenomegaly, Optic nerve compression, Anemia OMIM:259730
Blau Syndrome
Pericarditis, Cataract, Facial palsy, Keratitis, Splenomegaly, Large vessel vasculitis, Aortic an... ORPHA:90340
Diaphragmatic Hernia 4, With Cardiovascular Defects
Hepatomegaly, Ventricular septal defect, Optic nerve hypoplasia, Aortopulmonary collateral arteri... OMIM:620025
Amoebic Keratitis
Iris atrophy, Cataract, Abnormal corneal epithelium morphology, Abnormal anterior chamber morphol... ORPHA:67043
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome
Epistaxis, Cerebral arteriovenous malformation, Pulmonary arteriovenous malformation, Telangiecta... OMIM:175050
Paroxysmal Nocturnal Hemoglobinuria
Hemolytic anemia, Reticulocytosis, Pancytopenia, Myocardial infarction, Pulmonary embolism, Abnor... ORPHA:447
Full Nf2-Related Schwannomatosis
Facial palsy, Bilateral vestibular schwannoma, Retinal hamartoma, Myelopathy, Posterior subcapsul... ORPHA:637
Costello Syndrome
Epicanthus, Ventricular septal defect, Short stature, Mitral valve prolapse, Vestibular schwannom... OMIM:218040
Cleft Palate, Cardiac Defects, And Impaired Intellectual Development
Laterally extended eyebrow, Ventricular septal defect, Short stature, Highly arched eyebrow, Secu... OMIM:600987
15Q14 Microdeletion Syndrome
Atrial septal defect, Ventricular septal defect, Short stature ORPHA:261190

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Meis2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Meis2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline. Genesis (New York, N.Y. : 2000) (May 2016) Meis2tm1(KOMP)Wtsi PMC5084746

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MGI Allele Allele Type Produced
Meis2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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