Gene: Apbb2

Name
amyloid beta (A4) precursor protein-binding, family B, member 2
MGI ID
MGI:108405
Synonyms
TR2L 2310007D03Rik Rirl1 FE65L1 Zfra
Viability
Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
prenatal lethality prior to heart atrial septation Apbb2tm1.1(KOMP)Vlcg HOM embryonic day 14.5 0.00
abnormal eye morphology Apbb2tm1.1(KOMP)Vlcg HET postnatal 0.00
preweaning lethality, incomplete penetrance Apbb2tm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal skin morphology Apbb2tm1.1(KOMP)Vlcg HET postnatal 0.00
decreased total body fat amount Apbb2tm1.1(KOMP)Vlcg HET postnatal 3.85×10-05
increased mean corpuscular hemoglobin Apbb2tm1.1(KOMP)Vlcg HET postnatal 4.58×10-05
decreased circulating insulin level Apbb2tm1.1(KOMP)Vlcg HET postnatal 4.21×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (1/2) N/A
Aorta 2 No N/A
Blood 2 No N/A
Bone marrow 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2) N/A
Diaphragm 2 No N/A
Duodenum 2 No  (2/127) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (1/2) N/A
Eye 2 No  (1/2) N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No  (1/2) N/A
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (1/2) N/A
Jejunum 2 No  (6/127)  (1/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric adipose tissue 2 No  (1/2) N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (2/2) N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Quadriceps 2 No  (1/2) N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (1/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (1/2) N/A
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No  (1/2) N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584) N/A
Tongue 2 No  (5/127)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Trigeminal V nerve 2 No  (1/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vagina 2 No  (1/2) N/A
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 1  (1/47) N/A
Axial skeleton 6  (1/51)  (6/7) N/A
Brain 6  (6/485)  (7/7) N/A
Central nervous system ganglion 6  (1/51)  (7/7) N/A
Dorsal root ganglion 6  (1/47)  (7/7) N/A
Ear 6  (1/485)  (1/7) N/A
Embryo 6  (1/485)  (7/7) N/A
Outer ear 1  (1/47)  (1/2) N/A
Eye 6  (1/485)  (1/7) N/A
Foot 6  (1/485)  (1/7) N/A
Forebrain 6  (1/485) N/A
Forelimb 6  (1/485)  (7/7) N/A
Fronto-nasal process 6  (1/48)  (7/7) N/A
Gut 6  (1/50)  (2/7) N/A
Hand 6  (1/485)  (2/7) N/A
Head 6  (5/485)  (1/7) N/A
Head mesenchyme 6  (1/47)  (1/7) N/A
Heart 6  (1/485) N/A
Heart ventricle 1  (1/47) N/A
Hindbrain 6  (6/485)  (6/7) N/A
Hindlimb 6  (1/485)  (6/7) N/A
Liver 6  (1/485) N/A
Lung 6  (1/485)  (7/7) N/A
Mandibular process 6  (1/485) N/A
Maxillary process 6  (1/485)  (1/7) N/A
Meckel's cartilage 6 N/A
Midbrain 6  (1/485)  (7/7) N/A
Nasal septum 6  (1/47)  (7/7) N/A
Nose 6  (1/51)  (7/7) N/A
Notochord 6  (1/47) N/A
Oral cavity 6  (1/485)  (1/7) N/A
Outflow tract 1  (1/47) N/A
Pericardium 1  (1/46)  (1/2) N/A
Skeleton 6  (1/51)  (7/7) N/A
Skin 6  (1/485) N/A
Spinal cord 6  (1/50)  (7/7) N/A
Tail 6  (1/485) N/A
Tail somite 6  (1/485) N/A
Tongue 6  (1/46) N/A
Trunk mesenchyme 6  (1/47) N/A
Vibrissa 6  (1/47) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Apbb2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Apbb2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Apbb2tm448183(L1L2_GT1_LF2A_LacZ_BetactP_neo) Targeting vectors

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