Gene Summary

Name:
vanin 1
Synonyms:
V-1,  pantetheinase

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal locomotor activation Vnn1tm1Pna HOM Early adult 9.09×10-08
abnormal tail movements Vnn1tm1Pna HOM   Early adult 5.34×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vnn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Vnn1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Gait imbalance, Akinesia, Freezing of gait, Loss of ambulation, Falls, Unsteady gait, Short stepp... ORPHA:240094
Spinocerebellar Ataxia Type 27
Akinesia, Limb ataxia, Truncal ataxia, Gait disturbance, Difficulty walking, Gait ataxia ORPHA:98764
Parkinson Disease 17
Akinesia OMIM:614203
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia ORPHA:98773
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Shuffling gait, Gait ataxia, Short stepped shuffling gait ORPHA:391411
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Akinesia OMIM:618822
Spinocerebellar Ataxia 21
Akinesia, Ataxia, Progressive cerebellar ataxia, Limb ataxia, Gait ataxia OMIM:607454
Lissencephaly Type Iii And Bone Dysplasia
Akinesia OMIM:601160
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Corticobasal Syndrome
Gait disturbance, Akinesia ORPHA:454887
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Akinesia, Ataxia, Dysdiadochokinesis, Shuffling gait, Gait ataxia ORPHA:247234
Myopathy, Congenital, Compton-North
Akinesia OMIM:612540
Kufor-Rakeb Syndrome
Gait disturbance, Akinesia, Ataxia OMIM:606693
Manganese Poisoning
Gait disturbance, Akinesia ORPHA:306682
Perry Syndrome
Akinesia, Short stepped shuffling gait OMIM:168605
Classic Progressive Supranuclear Palsy Syndrome
Gait imbalance, Akinesia, Falls ORPHA:240071
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Aceruloplasminemia
Akinesia, Ataxia, Gait ataxia, Limb ataxia ORPHA:48818
Postencephalitic Parkinsonism
Akinesia ORPHA:97349
Autosomal Dominant Cerebellar Ataxia
Gait disturbance, Akinesia, Choreoathetosis, Progressive cerebellar ataxia ORPHA:99
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Gaucher Disease, Perinatal Lethal
Akinesia OMIM:608013
Hereditary Late-Onset Parkinson Disease
Shuffling gait, Akinesia ORPHA:411602
Supranuclear Palsy, Progressive, 2
Gait imbalance, Akinesia, Falls OMIM:609454
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Supranuclear Palsy, Progressive, 1
Gait imbalance, Akinesia, Falls OMIM:601104
Neurodegeneration With Brain Iron Accumulation 1
Gait disturbance, Akinesia, Ataxia, Choreoathetosis OMIM:234200
Dpagt1-Cdg
Akinesia, Ataxia, Inability to walk ORPHA:86309
African Trypanosomiasis
Gait disturbance, Akinesia, Difficulty walking, Choreoathetosis ORPHA:3385

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vnn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vnn1.

No publications found that use IMPC mice or data for Vnn1.

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MGI Allele Allele Type Produced
Vnn1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Vnn1tm378687(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Vnn1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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