Prkg1 | protein kinase, cGMP-dependent, type I

GeneMGI:108174Synonyms: Prkgr1b, Prkg1b

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

enlarged heart1 supporting datasetPrkg1tm1b(KOMP)WtsiheterozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetPrkg1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal duodenum morphology1 supporting datasetPrkg1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
preweaning lethality, incomplete penetrance1 supporting datasetPrkg1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
increased startle reflex1 supporting datasetPrkg1tm1b(KOMP)WtsiheterozygoteEarly adult3.69x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prkg1tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Prkg1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Prkg1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Prkg1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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