Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased food intake | Frrs1tm1a(EUCOMM)Wtsi | HET | Early adult | 7.27×10-05 | ||
preweaning lethality, incomplete penetrance | Frrs1tm1a(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
increased circulating free fatty acids level | Frrs1tm1a(EUCOMM)Wtsi | HET | Early adult | 6.07×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Frrs1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Bulimia Nervosa, Susceptibility To | Bulimia | OMIM:607499 | |
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy | Increased circulating free fatty acid level | ORPHA:293964 | |
D-Glyceric Aciduria | Hyperglycinemia, Nonketotic hyperglycinemia, Increased circulating free fatty acid level | ORPHA:941 | |
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency | Abnormal circulating acylcarnitine concentration, Increased circulating free fatty acid level, Hy... | ORPHA:71212 | |
Mandibuloacral Dysplasia | Hypercholesterolemia, Hypertriglyceridemia, Increased circulating free fatty acid level | ORPHA:2457 | |
Very Long Chain Acyl-Coa Dehydrogenase Deficiency | Elevated circulating creatine kinase concentration, Increased circulating free fatty acid level, ... | ORPHA:26793 | |
Congenital Disorder Of Glycosylation, Type Im | Increased circulating free fatty acid level | OMIM:610768 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Frrs1.
There are 7 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Frrs1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Frrs1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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