Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Smotm1b(KOMP)Wtsi HET Early adult 0.00
abnormal heart rate Smotm1b(KOMP)Wtsi HET Early adult 6.63×10-05
abnormal forebrain development Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal chorioallantoic fusion Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal allantois morphology Smotm1b(KOMP)Wtsi HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Smotm1b(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, complete penetrance Smotm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal vitelline vasculature morphology Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal pericardium morphology Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal embryo turning Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal sinus arrhythmia Smotm1b(KOMP)Wtsi HET Early adult 5.72×10-06
abnormal embryo size Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal visceral yolk sac morphology Smotm1b(KOMP)Wtsi HOM E9.5 0.00
abnormal PR interval Smotm1b(KOMP)Wtsi HET Early adult 1.89×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589) N/A
Aorta 2 No  (1/589)  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (3/589)  (2/2) N/A
Brainstem 2 No  (2/589)  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (3/589)  (2/2) N/A
Cerebral cortex 2 No  (2/589) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No  (1/589)  (2/2) N/A
Hippocampus 2 No  (3/589) N/A
Hypothalamus 2 No  (2/589) N/A
Kidney 2 No  (20/589)  (2/2) N/A
Large intestine 2 No  (10/589)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/589)  (2/2) N/A
Lung 2 No  (1/589) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2) N/A
Oral epithelium 2 No  (2/2) N/A
Ovary 2 No  (1/589)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/589) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (1/589)  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/589)  (2/2) N/A
Spinal cord 2 No  (2/589)  (2/2) N/A
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589)  (2/2) N/A
Striatum 2 No  (3/589)  (2/2) N/A
Testis 2 No  (5/589)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/589)  (2/2) N/A
Trachea 2 No  (2/589)  (2/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61)  (2/2) N/A
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 2  (6/506)  (2/2) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Cranium 2  (1/65)  (2/2) N/A
Dorsal root ganglion 2  (1/61)  (2/2) N/A
Ear 2  (1/506)  (2/2) N/A
Embryo 2  (1/507)  (2/2) N/A
Outer ear 2  (1/70)  (2/2) N/A
Eye 2  (1/506)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/56)  (2/2) N/A
Foot 2  (1/506)  (2/2) N/A
Forearm 2  (1/301)  (2/2) N/A
Forebrain 2  (1/506)  (2/2) N/A
Forelimb 2  (1/506)  (2/2) N/A
Fronto-nasal process 2  (1/62)  (2/2) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 2  (1/505)  (2/2) N/A
Head 2  (5/506)  (2/2) N/A
Head mesenchyme 2  (1/61)  (2/2) N/A
Heart 2  (1/506)  (2/2) N/A
Heart ventricle 2  (1/61)  (2/2) N/A
Hindbrain 2  (6/506)  (2/2) N/A
Hindlimb 2  (1/505)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/65)  (2/2) N/A
Inner ear 2  (1/65)  (2/2) N/A
Intestine 2  (1/59)  (2/2) N/A
Liver 2  (1/506)  (2/2) N/A
Lower leg 2  (1/301)  (2/2) N/A
Lung 2  (1/502)  (2/2) N/A
Mandibular process 2  (1/506)  (2/2) N/A
Maxillary process 2  (1/506)  (2/2) N/A
Mesonephros of female 2  (1/56)  (2/2) N/A
Mesonephros of male 2  (1/56)  (2/2) N/A
Metanephros 2  (1/56)  (2/2) N/A
Midbrain 2  (1/506)  (2/2) N/A
Nasal septum 2  (1/61)  (2/2) N/A
Nose 2  (1/74)  (2/2) N/A
Notochord 2  (1/61)  (2/2) N/A
Oral cavity 2  (1/506)  (2/2) N/A
Outflow tract 2  (1/61)  (2/2) N/A
Pancreas 2  (1/56)  (2/2) N/A
Pericardium 2  (1/56)  (2/2) N/A
Pharynx 2  (1/56)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/65)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/58)  (2/2) N/A
Skeleton 2  (1/74)  (2/2) N/A
Skin 2  (1/506)  (2/2) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Stomach 2  (1/56)  (2/2) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/56)  (2/2) N/A
Tongue 2  (1/56)  (2/2) N/A
Trachea 2  (1/60)  (2/2) N/A
Trunk mesenchyme 2  (1/61)  (2/2) N/A
Umbilical artery embryonic part 2  (1/61)  (2/2) N/A
Umbilical vein embryonic part 2  (1/61)  (2/2) N/A
Upper arm 2  (1/301)  (2/2) N/A
Upper leg 2  (1/301)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A
Vibrissa 2  (1/70)  (2/2) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images
X-ray: XRay Images Forepaw
9 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
Embryo LacZ: LacZ images wholemount
4 Images
Histopathology
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Smotm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Smotm199121(L1L2_Bact_P) Targeting vectors
Smotm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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