Gene: Smo

Name
smoothened, frizzled class receptor
MGI ID
MGI:108075
Synonyms
E130215L21Rik
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
prolonged PR interval Smotm1b(KOMP)Wtsi HET postnatal 2.47×10-05
abnormal embryo development Smotm1b(KOMP)Wtsi HOM embryonic day 9 0.00
abnormal pericardium morphology Smotm1b(KOMP)Wtsi HOM embryonic day 9 0.00
abnormal embryo turning Smotm1b(KOMP)Wtsi HOM embryonic day 9 0.00
embryonic lethality prior to tooth bud stage Smotm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal skin morphology Smotm1b(KOMP)Wtsi HET postnatal 0.00
preweaning lethality, complete penetrance Smotm1b(KOMP)Wtsi HOM n/a 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2) N/A
Oral epithelium 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47)  (2/2) N/A
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 2  (6/485)  (2/2) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Cranium 2  (1/46)  (2/2) N/A
Dorsal root ganglion 2  (1/47)  (2/2) N/A
Ear 2  (1/485)  (2/2) N/A
Embryo 2  (1/485)  (2/2) N/A
Outer ear 2  (1/47)  (2/2) N/A
Eye 2  (1/485)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/46)  (2/2) N/A
Foot 2  (1/485)  (2/2) N/A
Forearm 2  (1/282)  (2/2) N/A
Forebrain 2  (1/485)  (2/2) N/A
Forelimb 2  (1/485)  (2/2) N/A
Fronto-nasal process 2  (1/48)  (2/2) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 2  (1/485)  (2/2) N/A
Head 2  (5/485)  (2/2) N/A
Head mesenchyme 2  (1/47)  (2/2) N/A
Heart 2  (1/485)  (2/2) N/A
Heart ventricle 2  (1/47)  (2/2) N/A
Hindbrain 2  (6/485)  (2/2) N/A
Hindlimb 2  (1/485)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/46)  (2/2) N/A
Inner ear 2  (1/46)  (2/2) N/A
Intestine 2  (1/47)  (2/2) N/A
Liver 2  (1/485)  (2/2) N/A
Lower leg 2  (1/282)  (2/2) N/A
Lung 2  (1/485)  (2/2) N/A
Mandibular process 2  (1/485)  (2/2) N/A
Maxillary process 2  (1/485)  (2/2) N/A
Mesonephros of female 2  (1/46)  (2/2) N/A
Mesonephros of male 2  (1/46)  (2/2) N/A
Metanephros 2  (1/46)  (2/2) N/A
Midbrain 2  (1/485)  (2/2) N/A
Nasal septum 2  (1/47)  (2/2) N/A
Nose 2  (1/51)  (2/2) N/A
Notochord 2  (1/47)  (2/2) N/A
Oral cavity 2  (1/485)  (2/2) N/A
Outflow tract 2  (1/47)  (2/2) N/A
Pancreas 2  (1/46)  (2/2) N/A
Pericardium 2  (1/46)  (2/2) N/A
Pharynx 2  (1/46)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/46)  (2/2) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 2  (1/485)  (2/2) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Stomach 2  (1/46)  (2/2) N/A
Tail 2  (1/485)  (2/2) N/A
Tail somite 2  (1/485)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/46)  (2/2) N/A
Tongue 2  (1/46)  (2/2) N/A
Trachea 2  (1/50)  (2/2) N/A
Trunk mesenchyme 2  (1/47)  (2/2) N/A
Umbilical artery embryonic part 2  (1/47)  (2/2) N/A
Umbilical vein embryonic part 2  (1/47)  (2/2) N/A
Upper arm 2  (1/282)  (2/2) N/A
Upper leg 2  (1/282)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A
Vibrissa 2  (1/47)  (2/2) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
1 Images
X-ray: XRay Images Dorso Ventral
1 Images
X-ray: XRay Images Lateral Orientation
1 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
X-ray: XRay Images Forepaw
1 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Smotm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Smotm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Smotm199121(L1L2_Bact_P) Targeting vectors

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