Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Siah2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cystic Angiomatosis Of Bone, Diffuse | Cystic angiomatosis of bone | OMIM:123880 | |
Chromosome 14Q32 Duplication Syndrome, 700-Kb | Myelofibrosis | OMIM:616604 | |
Melorheostosis, Isolated | Hyperostosis, Increased bone mineral density | OMIM:155950 | |
Ghosal Hematodiaphyseal Dysplasia | Myelofibrosis, Increased bone mineral density, Hyperostosis cranialis interna | OMIM:231095 | |
Thrombocytopenia, Anemia, And Myelofibrosis | Myelofibrosis | OMIM:617441 | |
Thrombocytopenia 6 | Myelofibrosis, Osteoporosis | OMIM:616937 | |
Myelofibrosis | Myelofibrosis | OMIM:254450 | |
Essential Thrombocythemia | Myelofibrosis | ORPHA:3318 | |
Gray Platelet Syndrome | Myelofibrosis | OMIM:139090 | |
Acute Panmyelosis With Myelofibrosis | Myelofibrosis | ORPHA:86843 | |
Bleeding Disorder, Platelet-Type, 17 | Myelofibrosis | OMIM:187900 | |
Immunodeficiency 98 With Autoinflammation, X-Linked | Myelofibrosis | OMIM:301078 | |
Polycythemia Vera | Myelofibrosis | ORPHA:729 | |
Castleman Disease | Myelofibrosis | ORPHA:160 | |
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 | Myelofibrosis | OMIM:607721 | |
Idiopathic Hypereosinophilic Syndrome | Myelofibrosis | ORPHA:3260 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Siah2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Siah2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Siah2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter