Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
siah E3 ubiquitin protein ligase 2
Synonyms:
Sinh2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Siah2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Siah2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Superior Transverse Scapular Ligament, Calcification Of, Familial
Ectopic ossification in ligament tissue OMIM:601708
Chromosome 14Q32 Duplication Syndrome, 700-Kb
Myelofibrosis OMIM:616604
Distal Osteosclerosis
Craniofacial osteosclerosis, Hyperostosis, Diaphyseal sclerosis OMIM:126250
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Ghosal Hematodiaphyseal Dysplasia
Hyperostosis cranialis interna, Myelofibrosis, Increased bone mineral density OMIM:231095
Thrombocytopenia, Anemia, And Myelofibrosis
Myelofibrosis OMIM:617441
Thrombocytopenia 6
Myelofibrosis, Osteoporosis OMIM:616937
Myelofibrosis
Myelofibrosis OMIM:254450
Bleeding Disorder, Platelet-Type, 17
Myelofibrosis OMIM:187900
Essential Thrombocythemia
Myelofibrosis ORPHA:3318
Gray Platelet Syndrome
Myelofibrosis OMIM:139090
Acute Panmyelosis With Myelofibrosis
Myelofibrosis ORPHA:86843
Polycythemia Vera
Myelofibrosis ORPHA:729
Castleman Disease
Myelofibrosis ORPHA:160
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1
Myelofibrosis OMIM:607721
Idiopathic Hypereosinophilic Syndrome
Myelofibrosis ORPHA:3260

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Siah2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Siah2.

No publications found that use IMPC mice or data for Siah2.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Siah2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Siah2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Siah2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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