Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Rad21 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cornelia De Lange Syndrome | Hypoplasia of penis, Hypospadias, Cryptorchidism, Primary amenorrhea, Hypoplastic labia majora, A... | ORPHA:199 | |
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects | OMIM:614701 | ||
Mungan Syndrome | OMIM:611376 | ||
Trichorhinophalangeal Syndrome Type 2 | ORPHA:502 |
The table below shows human diseases predicted to be associated to Rad21 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cornelia De Lange Syndrome | Hypoplasia of penis, Hypospadias, Cryptorchidism, Primary amenorrhea, Hypoplastic labia majora, A... | ORPHA:199 | |
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects | OMIM:614701 | ||
Mungan Syndrome | OMIM:611376 | ||
Trichorhinophalangeal Syndrome Type 2 | ORPHA:502 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rad21.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes. | Current biology : CB (March 2019) | Rad21ltm1b(KOMP)Wtsi | 30853435 |
Sororin is enriched at the central region of synapsed meiotic chromosomes. | Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology (January 2017) | Rad21ltm1b(KOMP)Wtsi | PMC5441961 |
Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L. | G3 (Bethesda, Md.) (June 2016) | Rad21ltm1b(KOMP)Wtsi | PMC4889667 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Rad21tm277927(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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