Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Rhob by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rhob.
There are 5 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Rhobtb3tm1a(KOMP)Wtsi | PMC6671969 |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. | PLoS biology (April 2019) | Rhobtb3tm1a(KOMP)Wtsi | PMC6459510 |
RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. | Cell research (July 2015) | Rhobtb3tm1a(KOMP)Wtsi | PMC4559813 |
Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. | Histochemistry and cell biology (June 2014) | Rhobtb3tm1a(KOMP)Wtsi | 24923387 |
Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. | Disease models & mechanisms (March 2014) | Rhobtb3tm1a(KOMP)Wtsi | PMC4007403 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Rhobtm394588(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Rhobtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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