Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1

GeneMGI:107913Synonyms: mTIAR, 5330433G13Rik, +1 more

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Skeleton

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating triglyceride level1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult2.15x10-5 
decreased total body fat amount2 supporting datasetsTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult1.53x10-6 
thrombocytosis1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult1.54x10-5 
increased bone mineral density1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult3.55x10-6 
decreased circulating cholesterol level1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult8.44x10-9 
decreased circulating HDL cholesterol level1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult9.18x10-8 
increased lean body mass2 supporting datasetsTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult2.35x10-6 
decreased circulating calcium level1 supporting datasetTial1tm1b(EUCOMM)WtsiheterozygoteEarly adult6.26x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tial1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tial1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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