D6Wsu163e | DNA segment, Chr 6, Wayne State University 163, expressed

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

6 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:18Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased circulating fructosamine level1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult2.12x10-6 
increased circulating total protein level1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult2.94x10-8 
increased circulating cholesterol level1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult9x10-6 
increased CD8-positive, alpha-beta T cell number3 supporting datasetsD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased memory-marker NK cell number2 supporting datasetsD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased CD4-positive, alpha-beta T cell number2 supporting datasetsD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult4.54x10-9 
increased CD8-positive, naive alpha-beta T cell number1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating alkaline phosphatase level1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult4.93x10-75 
decreased circulating glucose level1 supporting datasetD6Wsu163etm1b(EUCOMM)WtsihomozygoteEarly adult2.25x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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D6Wsu163etm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
D6Wsu163etm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
D6Wsu163etm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
D6Wsu163etm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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