Tubb4a | tubulin, beta 4A class IVA

GeneMGI:107848Synonyms: Tubb, Tubb4

Physiological systems

18 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Homeostasis/metabolism

17 No significant impact

6 Not tested

Gene metrics:1Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

decreased fasting circulating glucose level1 supporting datasetTubb4atm1.1(KOMP)WtsihomozygoteEarly adult3.2x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Tubb4atm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
mouse
Tubb4atm1.1(KOMP)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Tubb4atm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Tubb4atm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Tubb4atm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Tubb4atm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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