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Gene: Prmt1 MGI:107846

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Gene Summary

Name:
protein arginine N-methyltransferase 1
Synonyms:
Hrmt1l2,  6720434D09Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Prmt1tm1a(EUCOMM)Wtsi HET   Early adult 2.30×10-05
decreased circulating total protein level Prmt1tm1a(EUCOMM)Wtsi HET   Early adult 8.98×10-05
decreased circulating glycerol level Prmt1tm1a(EUCOMM)Wtsi HET Early adult 1.60×10-05
preweaning lethality, complete penetrance Prmt1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
limb grasping Prmt1tm1a(EUCOMM)Wtsi HET   Early adult 3.42×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 75% (3 of 4)
Aorta N/A heterozygote Not available
Blood vessel N/A heterozygote 0.0% (0 of 4)
Bone N/A heterozygote 50% (2 of 4)
Brain N/A heterozygote 100% (4 of 4)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 4)
Cartilage tissue N/A heterozygote 75% (3 of 4)
Cerebellum N/A heterozygote Not available
Cerebral cortex N/A heterozygote Not available
Eye N/A heterozygote 50% (2 of 4)
Gall bladder N/A heterozygote 50% (2 of 4)
Heart N/A heterozygote 75% (3 of 4)
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Kidney N/A heterozygote 75% (3 of 4)
Large intestine N/A heterozygote 75% (3 of 4)
Liver N/A heterozygote 0.0% (0 of 4)
Lower urinary tract N/A heterozygote 75% (3 of 4)
Lung N/A heterozygote 50% (2 of 4)
Lymph node N/A heterozygote 75% (3 of 4)
Mammary gland N/A heterozygote 25% (1 of 4)
Esophagus N/A heterozygote 75% (3 of 4)
Olfactory lobe N/A heterozygote Not available
Ovary N/A heterozygote 50% (2 of 4)
Oviduct N/A heterozygote 50% (2 of 4)
Pancreas N/A heterozygote 75% (3 of 4)
Parathyroid gland N/A heterozygote 25% (1 of 4)
Peripheral nervous system N/A heterozygote 100% (4 of 4)
Peyer's patch N/A heterozygote 75% (3 of 4)
Pituitary gland N/A heterozygote 75% (3 of 4)
Prostate gland N/A heterozygote 50% (2 of 4)
Skeletal muscle tissue N/A heterozygote 100% (4 of 4)
Skin N/A heterozygote 75% (3 of 4)
Small intestine N/A heterozygote 75% (3 of 4)
Spinal cord N/A heterozygote 100% (4 of 4)
Spleen N/A heterozygote 75% (3 of 4)
Stomach N/A heterozygote 75% (3 of 4)
Striatum N/A heterozygote Not available
Testis N/A heterozygote 50% (2 of 4)
Thymus N/A heterozygote 75% (3 of 4)
Thyroid gland N/A heterozygote 25% (1 of 4)
Trachea N/A heterozygote 75% (3 of 4)
Uterus N/A heterozygote 50% (2 of 4)
White adipose tissue N/A heterozygote 0.0% (0 of 4)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (3 of 443)
aorta 0.0%
blood vessel 0.0%
bone 0.0%
brain 1.13% (5 of 443)
brainstem 0.46% (2 of 437)
brown adipose tissue 0.0%
cartilage tissue 0.23% (1 of 436)
cerebellum 0.7% (3 of 430)
cerebral cortex 0.22% (1 of 451)
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.46% (2 of 436)
hypothalamus 0.23% (1 of 436)
kidney 4.98% (22 of 442)
large intestine 4.92% (21 of 427)
liver 0.0%
lower urinary tract 0.0%
lung 0.45% (2 of 443)
lymph node 0.23% (1 of 426)
mammary gland 0.0%
oesophagus 0.0%
olfactory lobe 0.22% (1 of 446)
ovary 0.0%
oviduct 0.0%
pancreas 0.92% (4 of 437)
parathyroid gland 0.23% (1 of 432)
peripheral nervous system 0.23% (1 of 444)
peyer's patch 0.76% (1 of 132)
pituitary gland 0.24% (1 of 416)
prostate gland 1.85% (8 of 433)
skeletal muscle tissue 0.0%
skin 0.0%
small intestine 4.73% (21 of 444)
spinal cord 0.66% (3 of 453)
spleen 0.46% (2 of 434)
stomach 3.87% (17 of 439)
striatum 0.46% (2 of 438)
testis 1.12% (5 of 446)
thymus 0.23% (1 of 440)
thyroid gland 2.51% (11 of 438)
trachea 0.46% (2 of 433)
uterus 0.44% (2 of 459)
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Prmt1tm1a(EUCOMM)Wtsi
body, WT, Male, WTSI
Prmt1tm1a(EUCOMM)Wtsi
head, WT, Male, WTSI
Prmt1tm1a(EUCOMM)Wtsi
head, WT, Male, WTSI
Prmt1tm1a(EUCOMM)Wtsi
forearm, WT, Male, WTSI
Prmt1tm1a(EUCOMM)Wtsi
body, WT, Male, WTSI

View all 143 images

Prmt1tm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI
Prmt1tm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI
Prmt1tm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI

Human diseases caused by Prmt1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prmt1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Trypsinogen Deficiency
Hypoproteinemia OMIM:614044
Enterokinase Deficiency
Hypoproteinemia OMIM:226200
Gastritis, Familial Giant Hypertrophic
Hypoproteinemia OMIM:137280
Immunodeficiency 43
Hypoalbuminemia, Hypoproteinemia OMIM:241600
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Hypoproteinemia OMIM:221400
Enteropathy, Familial, With Villous Edema And Immunoglobulin G2 Deficiency
Hypoalbuminemia, Hypoproteinemia OMIM:600351
Aplasia Cutis Congenita With Intestinal Lymphangiectasia
Hypoproteinemia OMIM:207731
Nephrotic Syndrome, Type 1
Hyperlipidemia, Hypoalbuminemia, Hypoproteinemia OMIM:256300
Lymphangiectasia, Intestinal
Neonatal hypoproteinemia OMIM:152800
Congenital Analbuminemia
Hyperlipidemia, Hypoproteinemia, Increased alpha-globulin, Hypoalbuminemia, Hypercholesterolemia ORPHA:86816
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Hypoproteinemia ORPHA:1116
Citrullinemia Type Ii
Acute hyperammonemia, Hyperlipidemia, Hypoproteinemia, Decreased HDL cholesterol concentration, H... ORPHA:247585
Nephrotic Syndrome, Type 22
Hypoproteinemia OMIM:619155
Hemophagocytic Lymphohistiocytosis, Familial, 1
Increased circulating ferritin concentration, Hypoproteinemia, Increased LDL cholesterol concentr... OMIM:267700
Pancreatic insufficiency, combined exocrine
Hypoproteinemia OMIM:260450
Congenital Disorder Of Glycosylation, Type Ij
Tremor, Hypoproteinemia OMIM:608093
Refractory Celiac Disease
Hypomagnesemia, Hypophosphatemia, Hypocalcemia, Hypoproteinemia, Hypoalbuminemia ORPHA:398063
Ménétrier Disease
Hypoalbuminemia, Hypoproteinemia ORPHA:2494
Omenn Syndrome
Hypoproteinemia OMIM:603554
Hemophagocytic Lymphohistiocytosis, Familial, 2
Increased circulating ferritin concentration, Hypoproteinemia, Hypertriglyceridemia, Increased to... OMIM:603553
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypocalcemia, Hypoproteinemia, Hyperammonemia, Elevated circulating creatine kinase concentration... ORPHA:26793
Dengue Fever
Hypoproteinemia ORPHA:99828
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Hypoalbuminemia, Hypoproteinemia OMIM:226300
Primary Intestinal Lymphangiectasia
Hypomagnesemia, Hypocalcemia, Hypoalbuminemia, Hypoproteinemia ORPHA:90362
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Hypocalcemia, Hypoproteinemia OMIM:235255
Johanson-Blizzard Syndrome
Hypoproteinemia ORPHA:2315
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Elevated circulating creatine kinase concentration, Hypoproteinemia OMIM:615895
Chédiak-Higashi Syndrome
Increased circulating ferritin concentration, Hypoproteinemia, Hypertriglyceridemia, Tremor, Hypo... ORPHA:167
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hypocalcemia, Hypoproteinemia ORPHA:1655
Gaisböck Syndrome
Hyperproteinemia, Increased circulating renin level, Hypertriglyceridemia, Hyperuricemia, Hyperch... ORPHA:90041
Hemophagocytic Syndrome Associated With An Infection
Increased circulating ferritin concentration, Hypertriglyceridemia, Hyperproteinemia ORPHA:158048
Liver Disease, Severe Congenital
Increased circulating ferritin concentration, Hypocalcemia, Hyperbilirubinemia, Hypoproteinemia, ... OMIM:619991
Pierson Syndrome
Hypoproteinemia OMIM:609049
Multiple Myeloma
Hyperproteinemia, Elevated circulating creatinine concentration, Hypercalcemia ORPHA:29073
Juvenile Polyposis Syndrome
Hypoproteinemia ORPHA:2929
Leptospirosis
Hyperproteinemia ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prmt1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prmt1.

There are 24 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1. Frontiers in neuroscience (November 2022) Prmt1tm1c(EUCOMM)Wtsi PMC9685794
Inhibition of protein arginine methyltransferase 1 alleviates liver fibrosis by attenuating the activation of hepatic stellate cells in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (September 2022) Prmt1tm1c(EUCOMM)Wtsi 35959865
Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines. The Journal of allergy and clinical immunology (January 2021) Prmt1tm1a(EUCOMM)Wtsi 33476674
Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development. Journal of neurochemistry (September 2020) Prmt1tm1c(EUCOMM)Wtsi 33460120
Protein arginine methyltransferase-1 stimulates dopaminergic neuronal cell death in a Parkinson's disease model. Biochemical and biophysical research communications (June 2020) Prmt1tm1a(EUCOMM)Wtsi 32532423
The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma. The Journal of biological chemistry (April 2020) Prmt1tm1c(EUCOMM)Wtsi 32245889
Region-specific upregulation of HNK-1 glycan in the PRMT1-deficient brain. Biochimica et biophysica acta. General subjects (December 2019) Prmt1tm1c(EUCOMM)Wtsi 31884067
PRMT1 Is Required for the Maintenance of Mature β-Cell Identity. Diabetes (December 2019) Prmt1tm1c(EUCOMM)Wtsi Prmt1tm1a(EUCOMM)Wtsi 31848151
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes. Cell death & disease (December 2019) Prmt1tm1c(EUCOMM)Wtsi PMC6885520
Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation. Endocrinology (December 2019) Prmt1tm1c(EUCOMM)Wtsi PMC6853686
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Prmt1tm1a(EUCOMM)Wtsi PMC6671969
Hepatocyte PRMT1 protects from alcohol induced liver injury by modulating oxidative stress responses. Scientific reports (June 2019) Prmt1tm1a(EUCOMM)Wtsi PMC6591482
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Prmt1tm1a(EUCOMM)Wtsi PMC6459510
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. Autophagy (February 2019) Prmt1tm1c(EUCOMM)Wtsi 30653406
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation. Nature communications (November 2018) Prmt1tm1a(EUCOMM)Wtsi PMC6269446
PRMT1-Dependent Macrophage IL-6 Production Is Required for Alcohol-Induced HCC Progression. Gene expression (September 2018) Prmt1tm1a(EUCOMM)Wtsi PMC6466176
Gestational changes in PRMT1 expression of murine placentas. Placenta (April 2018) Prmt1tm1a(EUCOMM)Wtsi 29908641
Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice. Hepatology (Baltimore, Md.) (January 2018) Prmt1tm1c(EUCOMM)Wtsi 29023917
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer research (June 2017) Prmt1tm1a(EUCOMM)Wtsi PMC5581676
Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300. The Journal of biological chemistry (June 2017) Prmt1tm1c(EUCOMM)Wtsi PMC5555193
Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor γ-dependent macrophage differentiation. The Journal of biological chemistry (March 2017) Prmt1tm1c(EUCOMM)Wtsi PMC5409459
Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression. eLife (July 2016) Prmt1tm1a(EUCOMM)Wtsi PMC4996652
Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System. The Journal of biological chemistry (December 2015) Prmt1tm1c(EUCOMM)Wtsi Prmt1tm1a(EUCOMM)Wtsi PMC4732207
Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner. Hepatology (Baltimore, Md.) (October 2012) Prmt1tm1a(EUCOMM)Wtsi 22532369

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MGI Allele Allele Type Produced
Prmt1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Prmt1tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice

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