Ctsk | cathepsin K

GeneMGI:107823Synonyms: Cat K, catK

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Limbs/digits/tail Nervous system Skeleton

12 No significant impact

7 Not tested

Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased bone mineral density1 supporting datasetCtsktm1b(EUCOMM)HmguhomozygoteEarly adult3.53x10-9 
decreased prepulse inhibition3 supporting datasetsCtsktm1b(EUCOMM)HmguhomozygoteEarly adult6.64x10-10 
increased circulating alkaline phosphatase level1 supporting datasetCtsktm1b(EUCOMM)HmguhomozygoteEarly adult1.52x10-5 
short tibia1 supporting datasetCtsktm1b(EUCOMM)HmguhomozygoteEarly adult2.11x10-12 
abnormal uterus morphology1 supporting datasetCtsktm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ctsktm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Ctsktm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ctsktm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Ctsktm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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