Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Testis | Wholemount images | hemizygote | 100% (1 of 1) |
Vas deferens | Wholemount images | hemizygote | 100% (1 of 1) |
Adrenal gland | N/A | hemizygote | 0.0% (0 of 1) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 1) |
Aorta | N/A | hemizygote | 0.0% (0 of 1) |
Aorta | N/A | heterozygote | 0.0% (0 of 1) |
Bone | N/A | hemizygote | 0.0% (0 of 1) |
Bone | N/A | heterozygote | 0.0% (0 of 1) |
Brain | N/A | hemizygote | 0.0% (0 of 1) |
Brain | N/A | heterozygote | 0.0% (0 of 1) |
Brainstem | N/A | hemizygote | 0.0% (0 of 1) |
Brainstem | N/A | heterozygote | 0.0% (0 of 1) |
Brown adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Cartilage tissue | N/A | hemizygote | 0.0% (0 of 1) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 1) |
Cecum | N/A | hemizygote | 0.0% (0 of 1) |
Cecum | N/A | heterozygote | 0.0% (0 of 1) |
Cerebellum | N/A | hemizygote | 0.0% (0 of 1) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 1) |
Cerebral cortex | N/A | hemizygote | 0.0% (0 of 1) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 1) |
Esophagus | N/A | hemizygote | 0.0% (0 of 1) |
Esophagus | N/A | heterozygote | 0.0% (0 of 1) |
Eye | N/A | hemizygote | Not available |
Eye | N/A | heterozygote | Not available |
Gall bladder | N/A | hemizygote | 0.0% (0 of 1) |
Gall bladder | N/A | heterozygote | 0.0% (0 of 1) |
Heart | N/A | hemizygote | 0.0% (0 of 1) |
Heart | N/A | heterozygote | 0.0% (0 of 1) |
Hippocampus | N/A | hemizygote | 0.0% (0 of 1) |
Hippocampus | N/A | heterozygote | 0.0% (0 of 1) |
Hypothalamus | N/A | hemizygote | 0.0% (0 of 1) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 1) |
Kidney | N/A | hemizygote | 0.0% (0 of 1) |
Kidney | N/A | heterozygote | 0.0% (0 of 1) |
Large intestine | N/A | hemizygote | 0.0% (0 of 1) |
Large intestine | N/A | heterozygote | 0.0% (0 of 1) |
Liver | N/A | hemizygote | 0.0% (0 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | hemizygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | heterozygote | 0.0% (0 of 1) |
Lung | N/A | hemizygote | 0.0% (0 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 1) |
Lymph node | N/A | hemizygote | 0.0% (0 of 1) |
Lymph node | N/A | heterozygote | 0.0% (0 of 1) |
Mammary gland | N/A | hemizygote | 0.0% (0 of 1) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 1) |
Olfactory lobe | N/A | hemizygote | 0.0% (0 of 1) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 1) |
Oral epithelium | N/A | hemizygote | 0.0% (0 of 1) |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 1) |
Ovary | N/A | hemizygote | Not available |
Ovary | N/A | heterozygote | 0.0% (0 of 1) |
Oviduct | N/A | hemizygote | Not available |
Oviduct | N/A | heterozygote | 0.0% (0 of 1) |
Pancreas | N/A | hemizygote | 0.0% (0 of 1) |
Pancreas | N/A | heterozygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | hemizygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 1) |
Peyer's patch | N/A | hemizygote | 0.0% (0 of 1) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 1) |
Pituitary gland | N/A | hemizygote | 0.0% (0 of 1) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 1) |
Prostate gland | N/A | hemizygote | 0.0% (0 of 1) |
Prostate gland | N/A | heterozygote | Not available |
Skeletal muscle | N/A | hemizygote | 0.0% (0 of 1) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 1) |
Skin | N/A | hemizygote | 0.0% (0 of 1) |
Skin | N/A | heterozygote | 0.0% (0 of 1) |
Small intestine | N/A | hemizygote | 0.0% (0 of 1) |
Small intestine | N/A | heterozygote | 0.0% (0 of 1) |
Spinal cord | N/A | hemizygote | 0.0% (0 of 1) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 1) |
Spleen | N/A | hemizygote | 0.0% (0 of 1) |
Spleen | N/A | heterozygote | 0.0% (0 of 1) |
Stomach | N/A | hemizygote | 0.0% (0 of 1) |
Stomach | N/A | heterozygote | 0.0% (0 of 1) |
Striatum | N/A | hemizygote | 0.0% (0 of 1) |
Striatum | N/A | heterozygote | 0.0% (0 of 1) |
Testis | N/A | heterozygote | Not available |
Thymus | N/A | hemizygote | 0.0% (0 of 1) |
Thymus | N/A | heterozygote | 0.0% (0 of 1) |
Thyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Trachea | N/A | hemizygote | 0.0% (0 of 1) |
Trachea | N/A | heterozygote | 0.0% (0 of 1) |
Trigeminal V nerve | N/A | hemizygote | 0.0% (0 of 1) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 1) |
Uterus | N/A | hemizygote | Not available |
Uterus | N/A | heterozygote | 0.0% (0 of 1) |
Vas deferens | N/A | heterozygote | Not available |
Vascular system | N/A | hemizygote | 0.0% (0 of 1) |
Vascular system | N/A | heterozygote | 0.0% (0 of 1) |
White adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
olfactory lobe | 0.0% |
oral epithelium | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
uterus | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Pfkfb1
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pfkfb1.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
High-throughput discovery of novel developmental phenotypes. | Nature (September 2016) | Pfkfb1tm1b(KOMP)Wtsi | PMC5295821 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Pfkfb1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Pfkfb1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Pfkfb1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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