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Gene: Atp5f1b MGI:107801

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Gene Summary

Name:
ATP synthase F1 subunit beta
Synonyms:
Atp5b

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Atp5f1btm1b(EUCOMM)Hmgu HOM   E12.5 0.00
embryonic lethality prior to organogenesis Atp5f1btm1b(EUCOMM)Hmgu HOM   E9.5 0.00
decreased prepulse inhibition Atp5f1btm1b(EUCOMM)Hmgu HET Early adult 1.37×10-07
preweaning lethality, complete penetrance Atp5f1btm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Axial skeleton N/A heterozygote 100% (2 of 2)
Brain N/A heterozygote 25% (2 of 8)
Central nervous system ganglion N/A heterozygote 100% (2 of 2)
Ear N/A heterozygote 25% (2 of 8)
Embryo N/A heterozygote 100% (8 of 8)
Eye N/A heterozygote 25% (2 of 8)
Footplate N/A heterozygote 25% (2 of 8)
Forebrain N/A heterozygote 25% (2 of 8)
Forelimb N/A heterozygote 25% (2 of 8)
Gut N/A heterozygote 100% (2 of 2)
Handplate N/A heterozygote 25% (2 of 8)
Head N/A heterozygote 25% (2 of 8)
Heart N/A heterozygote 25% (2 of 8)
Hindbrain N/A heterozygote 25% (2 of 8)
Hindlimb N/A heterozygote 25% (2 of 8)
Liver N/A heterozygote 25% (2 of 8)
Lung N/A heterozygote 25% (2 of 8)
Mandibular process N/A heterozygote 25% (2 of 8)
Maxillary process N/A heterozygote 25% (2 of 8)
Midbrain N/A heterozygote 25% (2 of 8)
Nose N/A heterozygote 100% (2 of 2)
Oral cavity N/A heterozygote 25% (2 of 8)
Chorioallantoic placenta N/A heterozygote 100% (2 of 2)
Skeleton N/A heterozygote 100% (2 of 2)
Skin N/A heterozygote 25% (2 of 8)
Spinal cord N/A heterozygote 100% (2 of 2)
Tail somite N/A heterozygote 25% (2 of 8)
Tail N/A heterozygote 25% (2 of 8)
Trachea N/A heterozygote 100% (2 of 2)
Urinary system N/A heterozygote 100% (2 of 2)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
axial skeleton Ambiguous
brain 0.0%
central nervous system ganglion Ambiguous
ear 0.0%
embryo 0.0%
eye 0.0%
footplate 0.0%
forebrain 0.0%
forelimb 0.0%
gut Ambiguous
handplate 0.0%
head 0.0%
heart 0.0%
hindbrain 0.0%
hindlimb 0.0%
liver 0.0%
lung 0.0%
mandibular process 0.0%
maxillary process 0.0%
midbrain 0.0%
nose Ambiguous
oral cavity 0.0%
placenta Ambiguous
skeleton Ambiguous
skin 0.0%
spinal cord Ambiguous
tail 0.0%
tail somite group 0.0%
trachea Ambiguous
urinary system Ambiguous

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Gross Pathology and Tissue Collection

Images

8 Images

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Embryo LacZ

LacZ images wholemount

32 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Histopathology

Images

2 Images

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Combined SHIRPA and Dysmorphology

Images

1 Images

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Human diseases caused by Atp5f1b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Atp5f1b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
OMIM:620085

The table below shows human diseases predicted to be associated to Atp5f1b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
OMIM:620085

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Skin - MPATH pathological process term hypoplasia Atp5f1btm1b(EUCOMM)Hmgu HET Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atp5f1b.

No publications found that use IMPC mice or data for Atp5f1b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atp5f1btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Atp5f1btm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Atp5f1btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Atp5f1bem1(IMPC)Ccpcz Intra-exon deletion Mice, Tissue
Atp5f1btm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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