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Gene: Mesp1 MGI:107785

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mesoderm posterior 1
Synonyms:
bHLHc5

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mesp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mesp1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect, Type II lissencephaly OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Alg3-Cdg
Cerebral white matter atrophy, Microcephaly, Hypoplasia of the pons, Neural tube defect, Subcorti... ORPHA:79321
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Ventricular septal defect, Short stature, Microcephaly, Situs inversus totalis, Hy... ORPHA:1908
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Isolated Posterior Meningocele
Hydrocephalus, Meningocele, Lipomyelomeningocele, Neural tube defect, Increased head circumferenc... ORPHA:268810
Semilobar Holoprosencephaly
Short stature, Microcephaly, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube ... ORPHA:220386
Alobar Holoprosencephaly
Short stature, Microcephaly, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube ... ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Microcephaly, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube ... ORPHA:93926
Lobar Holoprosencephaly
Short stature, Microcephaly, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube ... ORPHA:93924

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mesp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mesp1.

No publications found that use IMPC mice or data for Mesp1.

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