Neurod2 | neurogenic differentiation 2

GeneMGI:107755Synonyms: Ndrf, bHLHa1

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:23Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased food intake1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult1.41x10-9 
abnormal coat appearance2 supporting datasetsNeurod2em1(IMPC)HmguheterozygoteEarly adult5.52x10-5 
narrow eye opening1 supporting datasetNeurod2em1(IMPC)HmguheterozygoteEarly adult2.26x10-5 
hyperactivity6 supporting datasetsNeurod2em1(IMPC)HmguhomozygoteEarly adult4.1x10-45 
cornea deposits1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult1.46x10-12 
decreased vertical activity1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult6.19x10-5 
increased anxiety-related response1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult2.44x10-6 
abnormal retina morphology1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult3.93x10-12 
narrow eye opening1 supporting datasetNeurod2em1(IMPC)HmguhomozygoteEarly adult2x10-11 
increased thigmotaxis2 supporting datasetsNeurod2em1(IMPC)HmguhomozygoteEarly adult1.35x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Neurod2em1(IMPC)HmguIntra-exon deletionmouse
Neurod2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Neurod2tm1.1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)ES Cell
Neurod2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Neurod2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Neurod2tm51163(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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