Gene Summary

Name:
La ribonucleoprotein 7, transcriptional regulator
Synonyms:
C330027G06Rik,  D3Wsu161e

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Larp7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Larp7 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Alazami Syndrome
Retractile testis OMIM:615071
Alazami Syndrome
ORPHA:319671

The table below shows human diseases predicted to be associated to Larp7 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect, Gonadal dysgenesis OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Hypospadias, Spina bifida ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Caudal Duplication
Abnormal penis morphology, Uterus didelphys, Myelomeningocele, Cryptorchidism, Spina bifida ORPHA:1756
Acalvaria
Holoprosencephaly, Hydrocephalus, Spina bifida ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Subependymal Nodular Heterotopia
Myelomeningocele, Meningocele, Occipital encephalocele, Nasofrontal encephalocele ORPHA:101030
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Intrauterine growth retardation, Encephalocele, Hydrocephalus, Meningocele, Ho... ORPHA:1908
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Schisis Association
Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Triploidy
Intrauterine growth retardation, Cryptorchidism, Ambiguous genitalia, Hydrocephalus, Meningocele,... ORPHA:3376
Meckel Syndrome, Type 4
Intrauterine growth retardation, Encephalocele, Hydrocephalus, Meningocele, Anencephaly OMIM:611134
Meckel Syndrome, Type 2
Intrauterine growth retardation, Meningocele, Anencephaly, Encephalocele OMIM:603194
Chiari Malformation Type Ii
Myelomeningocele, Cervical myelopathy, Hydrocephalus, Spina bifida OMIM:207950
Fryns Microphthalmia Syndrome
Unicornuate uterus, Neural tube defect OMIM:600776
Intellectual Developmental Disorder, Autosomal Dominant 72
Micropenis, Spina bifida, Shawl scrotum OMIM:620439
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Lumbar Syndrome
Bifid scrotum, Myelomeningocele, Cryptorchidism, Hypoplastic labia majora, Ambiguous genitalia, M... ORPHA:83628
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Autosomal Recessive Spondylocostal Dysostosis
Umbilical hernia, Abnormal morphology of female internal genitalia, Intrauterine growth retardati... ORPHA:2311
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Camptodactyly Syndrome, Guadalajara Type 1
Intrauterine growth retardation, Spina bifida ORPHA:1327
Wildervanck Syndrome
Meningocele ORPHA:3456
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Intrauterine growth retardation, Death in infancy, Spina bifid... ORPHA:1393
Pagod Syndrome
Abnormality of the uterus, Abnormal morphology of female internal genitalia, Female pseudohermaph... ORPHA:991
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Humero-Radial Synostosis
Meningocele ORPHA:3265
Sirenomelia
Ambiguous genitalia, Sirenomelia, Spina bifida ORPHA:3169
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Neurocutaneous Melanocytosis
Meningocele, Death in infancy ORPHA:2481
Amish Lethal Microcephaly
Spina bifida, Death in infancy ORPHA:99742
Czeizel-Losonci Syndrome
Myelomeningocele, Spina bifida occulta, Hydrocephalus, Spina bifida ORPHA:2437
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida, Death in infancy ORPHA:1120
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube defect ORPHA:268810
Pelvis-Shoulder Dysplasia
Hydranencephaly, Ambiguous genitalia, Hydrocephalus, Spina bifida ORPHA:2839
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Joubert Syndrome 14
Hydrocephalus, Meningocele, Encephalocele OMIM:614424
Acromelic Frontonasal Dysplasia
Meningocele, Encephalocele, Cryptorchidism ORPHA:1827
Mosaic Trisomy 9
Hypoplastic female external genitalia, Abnormality of the uterus, Intrauterine growth retardation... ORPHA:99776
Vacterl With Hydrocephalus
Intrauterine growth retardation, Cryptorchidism, Abnormal fallopian tube morphology, Hydrocephalu... ORPHA:3412
Iniencephaly
Spinal dysraphism, Myelomeningocele, Encephalocele, Hydrocephalus, Spina bifida, Holoprosencephal... ORPHA:63259
Neu-Laxova Syndrome
Hypogonadism, Intrauterine growth retardation, External genital hypoplasia, Ambiguous genitalia, ... ORPHA:2671
Trisomy 20P
Umbilical hernia, Cryptorchidism, Spina bifida, Macroorchidism, Hypospadias ORPHA:261318
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Fliedner-Zweier Syndrome
Meningocele OMIM:620511
Cloacal Exstrophy
Myelomeningocele, Abnormal fallopian tube morphology, Spina bifida, Abnormal clitoris morphology,... ORPHA:93929
Lateral Meningocele Syndrome
Meningocele, Cryptorchidism, Umbilical hernia ORPHA:2789
Lateral Meningocele Syndrome
Meningocele, Hydrocephalus, Cryptorchidism, Umbilical hernia OMIM:130720
Trisomy 18
Abnormal morphology of female internal genitalia, Intrauterine growth retardation, Cryptorchidism... ORPHA:3380
Chromosome 17P13.1 Deletion Syndrome
Hydrocele testis, Hydrocephalus, Spina bifida, Umbilical hernia OMIM:613776
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Neu-Laxova Syndrome 2
Intrauterine growth retardation, Spina bifida OMIM:616038
Phakomatosis Pigmentokeratotica
Precocious puberty, Spina bifida, Cryptorchidism ORPHA:2874
Fanconi Anemia
Abnormality of the uterus, Umbilical hernia, Hypogonadism, Azoospermia, Intrauterine growth retar... ORPHA:84
Lathosterolosis
Intrauterine growth retardation, Meningocele, Hypoplasia of penis ORPHA:46059
Phocomelia, Schinzel Type
Intrauterine growth retardation, Cryptorchidism, Aplasia of the uterus, Meningocele, Hypoplasia o... ORPHA:2879
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Intrauterine growth retardation, Short umbilical cord, Cryptorch... OMIM:256520
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Hypospadias, Meningocele, Occipital encephalocele ORPHA:397715
Exstrophy-Epispadias Complex
Penoscrotal transposition, Male sexual dysfunction, Female sexual dysfunction, Bifid scrotum, Cys... ORPHA:322
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida, Aplasia of the vagina OMIM:193500
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Micropenis, Anencephaly, Hydrocephalus, Occipital meningocele OMIM:616546
Hallermann-Streiff Syndrome
Spina bifida, Cryptorchidism OMIM:234100
Basal Cell Nevus Syndrome 1
Ovarian fibroma, Ovarian carcinoma, Hydrocephalus, Spina bifida OMIM:109400
Limb Body Wall Complex
Myelomeningocele, Encephalocele, Short umbilical cord, Hydrocephalus, Spina bifida, Spina bifida ... ORPHA:2369
Jacobsen Syndrome
Intrauterine growth retardation, Cryptorchidism, Spina bifida, Death in infancy ORPHA:2308
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Nail-Patella Syndrome
Spina bifida OMIM:161200
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
22Q11.2 Deletion Syndrome
Abnormality of the uterus, Umbilical hernia, Intrauterine growth retardation, Cryptorchidism, Hyd... ORPHA:567
Fibular Hemimelia
Spina bifida ORPHA:93323
Koolen-De Vries Syndrome Due To A Point Mutation
Precocious puberty, Cryptorchidism, Hydrocephalus, Spina bifida, Testicular neoplasm, Hypospadias ORPHA:363965
17Q21.31 Microdeletion Syndrome
Precocious puberty, Cryptorchidism, Hydrocephalus, Spina bifida, Testicular neoplasm, Hypospadias ORPHA:363958
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus, Spina bifida, Death in infancy OMIM:274000
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Hypospadias, Spina bifida ORPHA:508498
Campomelic Dysplasia
Spinal dysraphism, Hydrocephalus, Spina bifida, Hypospadias, Sex reversal OMIM:114290
Rubinstein-Taybi Syndrome 1
Bilateral cryptorchidism, Cryptorchidism, Premature thelarche, Spina bifida, Shawl scrotum, Spina... OMIM:180849
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Cutis Laxa, Autosomal Recessive, Type Ib
Death in childhood, Spina bifida, Neonatal death OMIM:614437
Aicardi Syndrome
Precocious puberty, Spina bifida OMIM:304050
Vater/Vacterl Association
Occipital encephalocele, Intrauterine growth retardation, Spina bifida, Patent urachus, Hypospadias OMIM:192350
Orofaciodigital Syndrome Vi
Occipital meningocele OMIM:277170
Otopalatodigital Syndrome, Type Ii
Umbilical hernia, Cryptorchidism, Hydrocephalus, Spina bifida, Stillbirth, Hypospadias OMIM:304120
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Holoprosencephaly 9
Alobar holoprosencephaly, Cryptorchidism, Hydrocephalus, Micropenis, Holoprosencephaly, Occipital... OMIM:610829
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Femoral-Facial Syndrome
Cryptorchidism, Encephalocele, Hypoplastic labia majora, Spina bifida, Micropenis OMIM:134780
Knobloch Syndrome 1
Spina bifida occulta, Occipital encephalocele, Occipital meningocele OMIM:267750
Arima Syndrome
Occipital meningocele OMIM:243910
Marfan Syndrome
Meningocele ORPHA:558
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Small scrotum, Occipital meningocele, Cryptorchidism, Anteriorly displaced genitalia, Aplasia of ... OMIM:276820
Alazami Syndrome
Retractile testis OMIM:615071
Alazami Syndrome
ORPHA:319671

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Larp7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Larp7.

No publications found that use IMPC mice or data for Larp7.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Larp7tm1dIcs Deletion allele (post-Flp and Cre with no reporter) Mice
Larp7tm1aIcs KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells
Larp7tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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